Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 28

Number of results on page
first rewind previous Page / 2 next fast forward last

Search results

help Sort By:

help Limit search:
first rewind previous Page / 2 next fast forward last
1
Publication available in full text mode
Content available

Problematics of fungal infections in the paranasal sinuses

100%
Nowak K., Szyfter W.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
716-721
EN
Fungal infections of the ear and paranasal sinus, are recognised quite rarely, but they make sometimes, for many reasons, very important diagnostic-therapy issue. Cantagion may developes near every paranasal sinus. Facilities to invasion give every states, which weaken general and punctual immunity (like immunosupression, chemo-sterydotherapy, blood disease, pregnancy and HIV). After penetrated organism, course of infections, in case of type of patogens, trim of the patient and localization, can have without symptoms, sharp, chronic or fulminant shape. The hardest course with the highest mortality occur in the cases of mucormycosis and aspergillosis. Actually curiosity occur cases of fungal infections, since this times consider to be unpathogenic for humans. For treatment of sinus mycosis in majority chirurgical treatment is required. In addition or the sake of morphological differentiation fungal, in their developing cycle, treatment mycosis recommends serious diffi culty, extra factor, which impeds therapy, is a must of prolongely antifungal treatment and repeated (to total elimination) remove hyphae from sinus, which stay sometimes even for week. Progress of the mycotic infections in paranasal sinus, remain bacterial infections and is often reason of bad diagnosis and incorrect treatment.
2
Publication available in full text mode
Content available

Trudności diagnostyczne i terapeutyczne inwazyjnej grzybicy zatok przynosowych o piorunującym przebiegu

100%
Szyfter W., Łączkowska-Przybylska J.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
710-715
PL
The autors present the diagnostic and therapeutical diffi culties of acute (fulminant) invasive mycotic rhinosinusitis. A case report of mycotic rhinosinusogenes meningitis in 50 years old woman is described in this paper. The intensive pharmacological and surgical treatment was performed. The result was successful, however the optical nerve was damaged.
3
Publication available in full text mode
Content available

Problematyka zakażeń grzybiczych w obrębie zatok przynosowych

100%
Nowak K., Szyfter W.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
716-721
PL
Fungal infections of the ear and paranasal sinus, are recognised quite rarely, but they make sometimes, for many reasons, very important diagnostic-therapy issue. Cantagion may developes near every paranasal sinus. Facilities to invasion give every states, which weaken general and punctual immunity (like immunosupression, chemo-sterydotherapy, blood disease, pregnancy and HIV). After penetrated organism, course of infections, in case of type of patogens, trim of the patient and localization, can have without symptoms, sharp, chronic or fulminant shape. The hardest course with the highest mortality occur in the cases of mucormycosis and aspergillosis. Actually curiosity occur cases of fungal infections, since this times consider to be unpathogenic for humans. For treatment of sinus mycosis in majority chirurgical treatment is required. In addition or the sake of morphological differentiation fungal, in their developing cycle, treatment mycosis recommends serious diffi culty, extra factor, which impeds therapy, is a must of prolongely antifungal treatment and repeated (to total elimination) remove hyphae from sinus, which stay sometimes even for week. Progress of the mycotic infections in paranasal sinus, remain bacterial infections and is often reason of bad diagnosis and incorrect treatment.
4
Publication available in full text mode
Content available

The diagnostic and therapeutical diffi culties of acute (fulminant) invasive mycotic rhinosinusitis

100%
Szyfter W., Łączkowska-Przybylska J.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
710-715
EN
The autors present the diagnostic and therapeutical diffi culties of acute (fulminant) invasive mycotic rhinosinusitis. A case report of mycotic rhinosinusogenes meningitis in 50 years old woman is described in this paper. The intensive pharmacological and surgical treatment was performed. The result was successful, however the optical nerve was damaged.
5
Publication available in full text mode
Content available

Analysis of the changes in the Polish Universal Neonatal Hearing Screening Program over 15 years of activity

81%
Greczka G., Zych M., Szyfter W., Wróbel M.
Otolaryngologia Polska
|
2018
|
vol. 72(2)
13-20
EN
Introduction: The Polish Universal Neonatal Hearing Screening Program (PUNHSP) is one example of a nationwide pro-health program in Poland. This program is aimed at early diagnosis and intervention in children with hearing impairment, and is an example of a well-managed program. Presenting the results of the PUNHSP, particularly organisational aspects and experience, can assist institutions managing other programs to achieve high efficiency. The aim of this work was to perform a detailed analysis of the PUNHSP by identifying the changes implemented over the 15 years it has been active, as well as the consequences of their introduction in terms of improved quality and efficiency. Materials and methods: Data from the PUNHSP, registered in the central database, were evaluated, as well as organisational information related to management, IT support and infrastructure. The analysis was based on quality assessment parameters (identification of changes and the purpose of their introduction) and effectiveness (consequences of introducing the changes). The analysis includes the 15-year period in which the PUNHSP has been active, from 2002 to 2017. Results: Thirteen main modifications of the program were identified according to the definition of “change”, in addition to 11 smaller modifications resulting from the necessity to adapt to current requirements. The changes were grouped into five categories: legal, administrative, management, audit and control, and IT. Discussion: The changes implemented in the PUNHSP can be assumed to have positively influenced various aspects of the program, but do not exhaust the possibilities for further optimisation of functioning. Conclusions: The program requires constant development in order to increase the efficiency and effectiveness of its operation, and the changes and solutions implemented in this program could be applied to improve existing pro-health programs, as well as those yet to be created.
6
Publication available in full text mode
Content available

The rare case of lipoma of posterior wall of the pharynx and parapharyngeal space

81%
Nowak K., Banaszewski J., Szyfter W.
|
2015
|
vol. 4(3)
48-51
EN
The paper presents the rare case of lipoma of parapharyngeal space and oropharynx in 46-year-old man who came out suddenly while eating, giving the feeling of an obstacle in the throat. Preoperative diagnosis was based on a characteristic image of KT (low density, presence of capsule, lack of contrast gain and the use of fat suppression technique). The tumor was surgically removed in its entirety, from reaching the mouth. Emphasized the rarity of tumors of the weaving within the parapharyngeal space and throat, conditioned by a small amount of fat in this area, as well as the possibility of turbulent obstructive symptoms caused by the sudden disclosure of a tumor located deep in the tissues.
7
Publication available in full text mode
Content available

Analiza zmian Programu Powszechnych Przesiewowych Badań Słuchu u Noworodków na przestrzeni 15 lat działania

81%
Greczka G., Zych M., Szyfter W., Wróbel M.
Otolaryngologia Polska
|
2018
|
vol. 72(2)
13-20
PL
Wstęp: Jednym z przykładów ogólnopolskiego programu prozdrowotnego w Polsce jest Program Powszechnych Przesiewowych Badań Słuchu u Noworodków (PPPBSuN). Jest on ukierunkowany na wczesną diagnostykę i interwencję u dzieci z zaburzeniami słuchu i podawany jako przykład programu dobrze zarządzanego. Prezentowanie wyników działania PPPBSuN, jak również aspektów organizacyjnych oraz własnych doświadczeń, mogą w znaczący sposób pomagać instytucjom zarządzającym innymi programami w osiąganiu wysokiej efektywności ich funkcjonowania. Celem niniejszej pracy jest szczegółowa analiza ewaluacji programu w okresie 15 lat jego działania, tj. identyfikacja zmian oraz konsekwencje ich wprowadzenia w perspektywie poprawy jakości i efektywności. Materiał i metody: Materiał stanowią dane dotyczące PPPBSuN, zarejestrowane w Centralnej Bazie Danych Programu, a także informacje organizacyjne związane z zarządzaniem, obsługą informatyczną oraz infrastrukturą PPPBSuN. Analizę przeprowadzono w oparciu o parametry oceny jakości (identyfikacje zmian i cel ich wprowadzenia) oraz efektywności (konsekwencje wprowadzenia zmian). Analiza dotyczy całego okresu funkcjonowania PPPBSuN – od 2002 do 2017 roku. Wyniki: W wyniku przeprowadzonej analizy zidentyfikowano 13 głównych modyfikacji programu spełniających kryteria „zmiany” oraz 11 mniejszych – pobocznych – wynikających z konieczności przystosowania funkcjonalności PPPBSuN do aktualnych potrzeb. Zmiany pogrupowano według pięciu kategorii: zmiany prawne, zmiany administracyjne, zmiany w zarządzaniu, audyt i kontrola oraz zmiany informatyczne. Dyskusja: Analizując ewaluację PPPBSuN można przyjąć, że wprowadzone zmiany, wpłynęły pozytywnie na poszczególne aspekty funkcjonowania PPPBSuN, ale nie wyczerpują możliwości dalszej optymalizacji jego działania. Program wymaga stałego rozwoju, tak by wzrastała skuteczność i efektywność jego działania, a zastosowane w nim rozwiązania mogły być bodźcem do ulepszania i tworzenia innych programów prozdrowotnych.
8
Publication available in full text mode
Content available

Doświadczenia w leczeniu rozległych zwężeń krtaniowo-tchawiczych z zastosowaniem metody poprzecznej resekcji tchawicy

81%
Szyfter W., Nowak K., Kruk-Zagajewska A.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
695-699
PL
The aim of this study is to evaluate the results obtained in Department of Otolaryngology et Oncology with transversal resection of trachea acc. to Pearson technique for postintubation stenosis. Methods. from January 2000 to January 2008 ten patients with subglottic postintubation stenosis underwent surgical treatment, using Pearsons method of operation with preservation of recurrent nerves and no postopereative tracheostomy. Mean stenosis length was 2 cm, the length of of airway resection was 1,5–4 cm. Results. There was no surgical or postoperative complications, all the patients get totally health, no restenosis was observed. The results confi rm that the Pearsons method of operation is an adequate treatment for subglottic stenosis.
9
Publication available in full text mode
Content available

Development of intracranial sinusogenic complications in the period of increased incidence of influenza infections – analysis of 6 patients hospitalized in the Department of Otolaryngology, Head and Neck Surgery of Poznan University of Medical Sciences in the year 2013

81%
Szyfter W., Bartochowska A., Borucki Ł., Kruk-Zagajewska A.
|
2015
|
vol. 4(3)
20-28
EN
In the period from January 2000 to the end of December 2013 in the Department of Otolaryngology, Head and Neck Surgery of Poznan University of Medical Sciences 21 patients with sinusogenic intracranial complications were treated. It should be emphasized that 6 patients in this group were hospitalized in 2013. In the previous analyzed years there were from 1 to 2 patients per year. This prompted the authors to a detailed presentation of all patients treated in 2013.
10
Publication available in full text mode
Content available

Rozwój wewnątrzczaszkowych powikłań zatokopochodnych w okresie zwiększonej zapadalności na grypę – przedstawienie 6 chorych hospitalizowanych w Klinice Otolaryngologii i Onkologii Laryngologicznej Uniwersytetu Medycznego w Poznaniu w 2013 r.

81%
Szyfter W., Bartochowska A., Borucki Ł., Kruk-Zagajewska A.
|
2015
|
vol. 4(3)
21-29
PL
W okresie od stycznia 2000 r. do końca grudnia 2013 r. w Klinice Otolaryngologii i Onkologii Laryngologicznej Uniwersytetu Medycznego w Poznaniu leczono 21 chorych z zatokopochodnymi powikłaniami wewnątrzczaszkowymi. Podkreślenia wymaga fakt, że aż 6 pacjentów z tej grupy hospitalizowano w 2013 r. We wcześniejszych analizowanych latach było od 1 do 2 pacjentów rocznie. Skłoniło to autorów do szczegółowego przedstawienia każdego chorego leczonego w 2013 r.
11
Publication available in full text mode
Content available

Experiences with treatment of extended laryngo-tracheal stenosis with employment of transversal resection of trachea

81%
Szyfter W., Nowak K., Kruk-Zagajewska A.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
695-699
EN
The aim of this study is to evaluate the results obtained in Department of Otolaryngology et Oncology with transversal resection of trachea acc. to Pearson technique for postintubation stenosis. Methods. from January 2000 to January 2008 ten patients with subglottic postintubation stenosis underwent surgical treatment, using Pearsons method of operation with preservation of recurrent nerves and no postopereative tracheostomy. Mean stenosis length was 2 cm, the length of of airway resection was 1,5–4 cm. Results. There was no surgical or postoperative complications, all the patients get totally health, no restenosis was observed. The results confi rm that the Pearsons method of operation is an adequate treatment for subglottic stenosis.
12
Publication available in full text mode
Content available

Rzadki przypadek tłuszczaka tylnej ściany gardła i przestrzeni przygardłowej

81%
Nowak K., Banaszewski J., Szyfter W.
|
2015
|
vol. 4(3)
50-53
PL
Praca przedstawia rzadki przypadek tłuszczaka okolicy przestrzeni przygardłowej oraz gardła środkowego u 46-letniego mężczyzny. Tłuszczak ujawnił się nagle podczas jedzenia, dając uczucie przeszkody w  gardle. Rozpoznanie przedoperacyjne ustalono na podstawie bardzo charakterystycznego obrazu KT (niska gęstość, obecność  torebki, brak wzmocnienia kontrastowego oraz wykorzystanie techniki z supresją tłuszczu). Guz został usunięty operacyjnie w całości, z dojścia przez jamę ustną. Podkreślono rzadkość występowania guzów o tym utkaniu w obrębie przestrzeni przygardłowej i gardła, uwarunkowaną niewielką ilością tkanki tłuszczowej w tej okolicy, a także możliwość powstania burzliwych objawów obturacji dróg oddechowych wywołanych nagłym ujawnieniem się guza położonego w tkankach głębokich.
13
Publication available in full text mode
Content available

Juvenile nasopharyngeal angiofibroma—20 years of experience in endoscopic treatment

71%
Szyfter W., Balcerowiak A., Gawęcki W., Juszkat R., Wierzbicka M.
Otolaryngologia Polska
|
2021
|
vol. 75(2)
9-14
EN
Introduction: Juvenile nasopharyngeal angiofibroma is a rare, benign tumor; however, it shows local aggression and leads to profuse nosebleeds. Aim: The aim of the study is to present 20 years of experience in endoscopic treatment of this tumor. Material and methods: The material covers 71 patients treated in the years 1985–2019 at the Department of Otolaryngology and Laryngological Oncology in Poznań. In these patients, either the classic external approach, or the double approach – external with the use of endoscopes, or only the endoscopic approach was used. In the entire population, external surgeries were performed in 37 patients, double access in 8 and endoscopic access in 26 patients. Results: Complete resection of the tumor was achieved in 51 patients (72%). The remaining 20 patients (28%) had a residual or recurrent tumor and all of these patients underwent reoperation. Conclusions: The endoscopic approach with the use of various optics and navigation allows for the removal of not only small tumors but also much more advanced ones. Pre-operative evaluation of imaging results is extremely important to avoid incomplete tumor removal. Individual development of an operating strategy, a wide range of optics and various surgical methods, and especially endoscopic ones, are the guarantee of therapeutic success.
14
Publication available in full text mode
Content available

Current indications for cochlear implantation in adults and children

71%
Szyfter W., Karlik M., Sekula A., Harris S., Gawęcki W.
Otolaryngologia Polska
|
2019
|
vol. 73(3)
1-5
EN
Introduction: Surgical treatment of deafness by cochlear implants is used for more than 40 years, and during this period permanently, gradual and significant expansion of indications for this surgery has been observed. Material and methods: In our Department in the years 1994-2018 1480 cochlear implantations were performed, both in adults (647) and in children (883). In this study current indications and the rules for eligibility of patients based on 25 years of experience are presented. Results: Indications for cochlear implantation in adults are: 1) bilateral postlingual deafness, 2) bilateral sensorineural hearing loss - in pure tone audiometry > 70 dB HL (average 500-4000 Hz) and in speech audiometry in hearing aids understanding < 50% of words for the intensity of the stimulus 65 dB, in the absence of the benefits of hearing aids, 3) bilateral profound hearing loss for high frequency with good hearing for low frequency, in the absence of the benefits of hearing aids, 4) some cases of asymmetric hearing loss with intensive tinnitus in the deaf ear. An indication in children is bilateral sensorineural hearing loss > 80dB HL confirmed by hearing tests, after about 6 months of rehabilitation with the use of hearing aids. Discussion: Although cochlear implantation is used for more than 40 years, the indications for this treatment underlies constant modifications. They concern the age of eligible patients, implantation in patients with partially preserved hearing, as well as treatment for patients with difficult anatomical conditions. In many countries, bilateral implantations are commonly performed, and more and more centers recommend this treatment in the case of unilateral deafness or asymmetric hearing loss, especially with the accompanying tinnitus in the deaf ear.
15
Publication available in full text mode
Content available

Znaczenie postępowania pooperacyjnego w operacjach czynnościowych nosa i zatok przynosowych

71%
Mielcarek-Kuchta D., Leszczyńska M., Szyfter W., Wielgosz R., Pastusiak T.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
705-709
PL
Introduction. In this work we wish to emphasize the importance of postoperative care of patients who underwent FESS in ENT Department Medical University in Poznań. We feel that too little attention is still being paid to this treatment as we mostly focus on surgery. Material and methods. Our observation are based on nine year experience in functional endoscopic sinus surgery. The analysis covers patients hospitalized in our Department from January 1998 to August 2007. The schedule of postoperative care has been presented. Results. 1463 FESS operation were carried out in our Department from January 1998 to August 2007. Similar postoperative procedures were used with each patient. Full recovery of mucous membrane depended on a few parameters such as: if the patient underwent FESS for the fi rst time, what kind of changes were observed: polips or chronic infection, as well as the method of surgery (“aggressive” versus “delicate”). Healing time ranged from 6 week to 3 month. Conclusions. The scheme of procedures employed comes useful in postoperative treatment after FESS.
16
Publication available in full text mode
Content available

Analysis of molecular background of hereditary haemorrhagic telangiectasia – Rendu-Osler-Weber disease – preliminary results

71%
Kostrzewska-Poczekaj M., Wróbel M., Rydzanicz M., Szyfter W., Szyfter K.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
700-704
EN
Introduction. Hereditary haemorrhagic telangiectasia (HHT) known also as Rendu-Osler-Weber syndrome is an autosomal dominant disorder characterized by localized angiodysplasia due to mutations in ENG (endoglin, 9q34.1) or ALK-1 gene (the activin receptor-like kinase 1, 12q13). ENG and ALK-1 are found associated with two disease subtypes designated as HHT1 and HHT2, respectively. Subtype HHT1 remains in the frame of interest of laryngology because of frequent bleeding in head and neck region. Material and method. The study was designed to identify a genetic background in a large family (29 individuals) with diagnosed HHT. Pedigree analysis showed autosomal dominant pattern of inheritance. Study design comprised segregation analysis to determine locus with subsequent direct sequencing of the gene. Four microsatelite markers (d9s61, d9s65, d12s368, d12s347) with high frequency of heterozygosity in population study were used. Results. The results concerning heterozygosity ranged from 15% to 53%. The established differences were not suffi cient enough to indicate cosegregation of the studied loci. DNA sequence analysis in exon 11 of ENG gene did not reveal mutations. The latter result could be explained by an occurrence of mutations in other exons of ENG. Conclusions. The study requires continuation for gene identifi cation and precise genotype-phenotype correlation aiming for an improvement of HHT1 therapy.
17
Publication available in full text mode
Content available

Naczyniakowłókniak młodzieńczy – 20–letnie doświadczenia w leczeniu endoskopowym

71%
Szyfter W., Balcerowiak A., Gawęcki W., Juszkat R., Wierzbicka M.
Otolaryngologia Polska
|
2021
|
vol. 75(2)
9-14
PL
Wstęp: Naczyniakowłókniak młodzieńczy to rzadko występujący guz niezłośliwy, wykazujący jednak agresję miejscową i prowadzący do obfitych krwawień z nosa. Cel: Celem niniejszej pracy jest przedstawienie 20-letnich doświadczeń w leczeniu endoskopowym tego guza.Materiał i metoda: Materiał obejmuje 71 chorych leczonych w latach 1985–2019 w Klinice Otolaryngologii i Onkologii Laryngologicznej w Poznaniu. U wspomnianych pacjentów stosowano albo dojście klasyczne od zewnątrz, albo dojście podwójne- -klasyczne z użyciem endoskopów, albo tylko dojście endoskopowe. W całej tej populacji operację od zewnątrz wykonano u 37 chorych, dojście podwójne zastosowano u 8, a endoskopowe u 26 chorych. Wyniki: Całkowitą resekcję guza uzyskano u 51 osób (72%). U pozostałych 20 (28%) stwierdzono guz przetrwały lub wznowę i wszystkich tych chorych poddano ponownej operacji. Wnioski: Dojście endoskopowe z użyciem różnych optyk i nawigacji daje możliwość usuwania nie tylko małych guzów, ale także tych znacznie bardziej zaawansowanych. Niezwykle ważna jest ocena przedoperacyjna badań obrazowych dla uniknięcia niecałkowitego usunięcia guza. Indywidualne opracowanie strategii operacyjnej, szeroki wachlarz optyk i różnych metod chirurgicznych ze wskazaniem na endoskopowe są gwarantem sukcesu terapeutycznego.
18
Publication available in full text mode
Content available

Aktualne wskazania do implantacji ślimakowej u dorosłych i u dzieci

71%
Szyfter W., Karlik M., Sekula A., Harris S., Gawęcki W.
Otolaryngologia Polska
|
2019
|
vol. 73(3)
1-5
PL
Wstęp: Chirurgiczne leczenie głuchoty metodą implantów ślimakowych stosowane jest od ponad 40 lat. W tym czasie obserwuje się stałe, stopniowe i istotne poszerzanie wskazań do tego zabiegu. Materiał i metody: W naszym ośrodku w latach 1994–2018 założono 1480 różnego typu implantów ślimakowych – 647 u dorosłych oraz 883 u dzieci. W niniejszej pracy przedstawiono obecne wskazania oraz zasady kwalifikacji pacjentów wypracowane w oparciu o 25-letnie doświadczenie. Wyniki: Wskazania do implantacji ślimakowej u osób dorosłych stanowią: 1) obustronna głuchota postlingwalna, 2) obustronny niedosłuch czuciowo-nerwowy – w audiometrii tonalnej >70 dB HL (średnia 500–4000 Hz) i w audiometrii słownej rozumienie mowy w aparatach słuchowych <50% dla natężenia bodźca 65 dB przy braku korzyści z aparatów słuchowych, 3) obustronny głęboki niedosłuch dla częstotliwości wysokich z zachowaniem częstotliwości niskich przy braku korzyści z aparatów słuchowych, 4) niektóre przypadki asymetrycznego niedosłuchu z nasilonymi szumami w uchu głuchym. Wskazaniem u dzieci jest obustronny niedosłuch czuciowo-nerwowy >80 dB HL wyznaczony na podstawie badań słuchu po około 6-miesięcznej rehabilitacji z użyciem aparatów słuchowych. Dyskusja: Choć implantacja ślimakowa stosowana jest od ponad 40 lat, wskazania do tego zabiegu podlegają stałym modyfikacjom. Dotyczą one wieku kwalifikowanych pacjentów, implantacji u pacjentów z częściowo zachowanym słuchem, a także zabiegów u chorych z trudnymi warunkami anatomicznymi. W wielu krajach powszechnie wykonywane są też implantacje obustronne, a coraz liczniejsze ośrodki rekomendują ten zabieg w przypadku jednostronnej głuchoty lub asymetrycznego niedosłuchu, zwłaszcza z towarzyszącym szumem usznym w uchu głuchym.
19
Publication available in full text mode
Content available

Analiza uwarunkowań genetycznych wrodzonej naczyniakowatości krwotocznej choroby Rendu-Oslera-Webera – doniesienia wstępne

71%
Kostrzewska-Poczekaj M., Wróbel M., Rydzanicz M., Szyfter W., Szyfter K.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
700-704
PL
Introduction. Hereditary haemorrhagic telangiectasia (HHT) known also as Rendu-Osler-Weber syndrome is an autosomal dominant disorder characterized by localized angiodysplasia due to mutations in ENG (endoglin, 9q34.1) or ALK-1 gene (the activin receptor-like kinase 1, 12q13). ENG and ALK-1 are found associated with two disease subtypes designated as HHT1 and HHT2, respectively. Subtype HHT1 remains in the frame of interest of laryngology because of frequent bleeding in head and neck region. Material and method. The study was designed to identify a genetic background in a large family (29 individuals) with diagnosed HHT. Pedigree analysis showed autosomal dominant pattern of inheritance. Study design comprised segregation analysis to determine locus with subsequent direct sequencing of the gene. Four microsatelite markers (d9s61, d9s65, d12s368, d12s347) with high frequency of heterozygosity in population study were used. Results. The results concerning heterozygosity ranged from 15% to 53%. The established differences were not suffi cient enough to indicate cosegregation of the studied loci. DNA sequence analysis in exon 11 of ENG gene did not reveal mutations. The latter result could be explained by an occurrence of mutations in other exons of ENG. Conclusions. The study requires continuation for gene identifi cation and precise genotype-phenotype correlation aiming for an improvement of HHT1 therapy.
20
Publication available in full text mode
Content available

The importance of postoperative care after functional endoscopic sinus surgery

71%
Mielcarek-Kuchta D., Leszczyńska M., Szyfter W., Wielgosz R., Pastusiak T.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
705-709
EN
Introduction. In this work we wish to emphasize the importance of postoperative care of patients who underwent FESS in ENT Department Medical University in Poznań. We feel that too little attention is still being paid to this treatment as we mostly focus on surgery. Material and methods. Our observation are based on nine year experience in functional endoscopic sinus surgery. The analysis covers patients hospitalized in our Department from January 1998 to August 2007. The schedule of postoperative care has been presented. Results. 1463 FESS operation were carried out in our Department from January 1998 to August 2007. Similar postoperative procedures were used with each patient. Full recovery of mucous membrane depended on a few parameters such as: if the patient underwent FESS for the fi rst time, what kind of changes were observed: polips or chronic infection, as well as the method of surgery (“aggressive” versus “delicate”). Healing time ranged from 6 week to 3 month. Conclusions. The scheme of procedures employed comes useful in postoperative treatment after FESS.
first rewind previous Page / 2 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.