Search results

1

Transesophageal three-dimensional echocardiography improves the safety of transvenous extraction of pacemaker and implantable cardioverter-defibrillator leads – preliminary report

100%

Kempa M., Daniłowicz-Szymanowicz L., Budrejko S., Raczak G.

European Journal of Translational and Clinical Medicine

|

2018

|

vol. 1

|

issue 1

67-69

EN

This article demonstrates the echocardiographic method to assess the placement of pacemaker and implantable cardioverter-defibrillator leads in the vicinity of the superior vena cava as a way to increase the safety of transvenous lead extraction (TLE). Three-dimensional transesophageal echocardiography was performed in 3 patients during TLE with the use of the Specranetics Excimer Laser device. We assessed the following parameters: lead adherence to the lateral wall of the vessel and lead movement. This method increased the safety of the performed TLE.

2

Transesophageal three-dimensional echocardiography improves the safety of transvenous extraction of pacemaker and implantable cardioverter-defibrillator leads – preliminary report

100%

Kempa M., Daniłowicz-Szymanowicz L., Budrejko S., Raczak G.

|

2018

|

vol. 1

|

issue 1

67-69

EN

This article demonstrates the echocardiographic method to assess the placement of pacemaker and implantable cardioverter-defibrillator leads in the vicinity of the superior vena cava as a way to increase the safety of transvenous lead extraction (TLE). Three-dimensional transesophageal echocardiography was performed in 3 patients during TLE with the use of the Specranetics Excimer Laser device. We assessed the following parameters: lead adherence to the lateral wall of the vessel and lead movement. This method increased the safety of the performed TLE.

3

Risk factors for poor prognosis in heart failure with particular attention to the elderly population

88%

Dobrowolska M., Miękus P., Świątczak M., Raczak G., Daniłowicz-Szymanowicz L.

European Journal of Translational and Clinical Medicine

|

2021

|

vol. 4

|

issue 2

18-30

EN

Background: Heart failure (HF) is a leading cause of poor outcome. Age is considered one of the most critical risk factors for both the incidence and prognosis of HF. Therefore we aimed to assess the predictors of poor prognosis in HF patients with particular attention to the elderly population. Material and methods: We retrospectively enrolled patients hospitalized due to HF exacerbation during 2016-2017 (203 patients). The end-points were all-cause mortality and emergency rehospitalizations within a two-year follow-up period. A detailed analysis was performed in the subgroups of patients younger and older than 65 years old. Results: 121 (60%) patients experienced the end-points. Age, low systolic blood pressure, NYHA class IV, right ventricle HF symptoms, high C-reactive protein, troponin, NT-proBNP, hyponatremia, catecholamine therapy and mechanical ventilation during hospitalization independently predicted the end-points. The elderly were characterized by a higher incidence of concomitant diseases and HF with moderately reduced or preserved LVEF, worse laboratory parameters and pharmacological treatment, as well as worse prognosis. Conclusion: The prognosis of patients hospitalized due to HF, mainly the elderly, is poor. Simple clinical parameters could be useful in further decision-making regarding the intensification of their treatment.

4

Clinical and laboratory assessment of patients with new-onset atrial fibrillation in acute myocardial infarction

76%

Raczkowska-Golanko M., Daniłowicz-Szymanowicz L., Nowak R., Puchalski W., Gruchała M., Kozłowski D., Raczak G.

|

2018

|

vol. 1

|

issue 1

39-43

EN

Background New-onset atrial fibrillation (NOAF) is one of the complications of acute myocardial infarction (AMI), and is associated with poor outcome. The aim of the study was clinical and laboratory assessment of patients with NOAF in AMI. Material and methods This is a retrospective, single-centre study of AMI patients with NOAF, who were admitted to Clinical Centre of Cardiology of the University Clinical Centre in Gdansk, from January 2016 to June 2018. The medical history, echocardiography parameters, AMI localization and infarcted-related artery as well as laboratory parameters at the admission and at the moment of NOAF onset were taken into further analyses. Results From 1155 consecutive AMI patients 103 (8.9%) with NOAF were enrolled into the study. A significant increase in C-reactive protein (CRP) and high-sensitive Troponine I (hsTnI) level, whereas significant decrease in potassium and hemoglobin level was observed at the moment of NOAF in comparison to admission. Conclusions Our study suggests that markers of inflammation (CRP), myocardial necrosis (hsTnI), hemoglobin and serum potassium may be associated with NOAF in the setting on AMI. The aforementioned parameters are generally available and may be used as an inexpensive and rapid way to select patients who are at high risk of developing NOAF.

5

Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

76%

Rozwadowska K., Daniłowicz-Szymanowicz L., Fijałkowski M., Sikorska K., Szymanowicz W., Lewicka E. K., Raczak G.

|

2018

|

vol. 1

|

issue 1

20-25

EN

Background Hereditary haemochromatosis (HH) is an inherited disease in which gene mutation leads to excessive iron absorption and accumulation in different organs, including the heart, which causes damage. Whether the age of patients with HH at the moment of their first diagnosis has an additional effect on the standard echocardiographic parameters was the aim of the study. Material and methods We prospectively enrolled 20 HH patients, and 20 healthy age- and sex-matched volunteers. Analysis of standard echocardiographic parameters was performed and compared in subgroups of ≥50 and <50 years old (yo). Results Comparing HH patients with healthy volunteers in ≥50 yo subgroup, significant differences were found in parameters regarding diastolic function (IVS thickness, LVM index, Em, E/Em, PV S/D, LAA index and LAV index). In the <50 yo subgroup we did not find the abovementioned differences, however LVEF appeared to be lower in the HH patients. Conclusions Despite the lack of clinical symptoms of cardiovascular disease and the lack of deviations in the standard echocardiographic examination, there were a number of differences regarding LV diastolic function parameters in HH patients ≥50 yo, whereas differences regarding LV systolic function were more prominent in HH patients <50 yo when compared with healthy subjects.

6

Expression profile of circulating microRNAs in patients with ischemic heart failure with moderately reduced left ventricular ejection fraction – pilot study

76%

Kaufmann D., Daniłowicz-Szymanowicz L., Sakowicz-Burkiewicz M., Szwoch M., Pawełczyk T., Raczak G.

European Journal of Translational and Clinical Medicine

|

2019

|

vol. 1

|

issue 2

53-57

EN

Introduction: Heart failure (HF) is a growing global pandemic that affects millions of people around the world. Despite the progress in medicine, diagnosis and treatment of HF remains problematic. Recently, noncoding micro ribonucleic acids called miRNAs have become significant in the diagnosis and stratification of HF risk. Aim: The aim of this study was the attempt to identify the profile of circulating miRNAs specific for ischemic HF with moderately reduced left ventricular ejection fraction (HFmrEF). Methods and Results: A number of changes in the miRNA profile can characterise patients with ischemic HFmrEF. This is a pilot study before further research on a larger group of patients. Conclusions: Using the quantitative reverse transcription-polymerase chain reaction (qRT-PCR), serum levels of 84 miRNA were measured and compared between a patient with ischemic HFmrEF and a healthy volunteer. Analysis reveals a down-regulation of let-7f-5p and miR-1-3p, as well as up-regulation of miR-100-5p, miR-10b-5p, miR-125a-5p, miR-140-5p, miR-144-3p, miR-149-5p, miR-15b-5p, miR-183-5p, miR-208b-3p, miR-224-5p, miR-26b-5p, miR-27b-3p, miR-302a-3p, miR-320a, miR-7-5p, miR-99a-5p.

7

Clinical and laboratory assessment of patients with new-onset atrial fibrillation in acute myocardial infarction

76%

Raczkowska-Golanko M., Daniłowicz-Szymanowicz L., Nowak R., Puchalski W., Gruchała M., Kozłowski D., Raczak G.

European Journal of Translational and Clinical Medicine

|

2018

|

vol. 1

|

issue 1

39-43

EN

Background: New-onset atrial fibrillation (NOAF) is one of the complications of acute myocardial infarction (AMI), and is associated with poor outcome. The aim of the study was clinical and laboratory assessment of patients with NOAF in AMI. Material and methods: This is a retrospective, single-centre study of AMI patients with NOAF, who were admitted to Clinical Centre of Cardiology of the University Clinical Centre in Gdansk, from January 2016 to June 2018. The medical history, echocardiography parameters, AMI localization and infarcted-related artery as well as laboratory parameters at the admission and at the moment of NOAF onset were taken into further analyses. Results: From 1155 consecutive AMI patients 103 (8.9%) with NOAF were enrolled into the study. A significant increase in C-reactive protein (CRP) and high-sensitive Troponine I (hsTnI) level, whereas significant decrease in potassium and hemoglobin level was observed at the moment of NOAF in comparison to admission. Conclusions: Our study suggests that markers of inflammation (CRP), myocardial necrosis (hsTnI), hemoglobin and serum potassium may be associated with NOAF in the setting on AMI. The aforementioned parameters are generally available and may be used as an inexpensive and rapid way to select patients who are at high risk of developing NOAF.

8

Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

76%

Rozwadowska K., Daniłowicz-Szymanowicz L., Fijałkowski M., Sikorska K., Szymanowicz W., Lewicka E. K., Raczak G.

European Journal of Translational and Clinical Medicine

|

2018

|

vol. 1

|

issue 1

20-25

EN

Background: Hereditary haemochromatosis (HH) is an inherited disease in which gene mutation leads to excessive iron absorption and accumulation in different organs, including the heart, which causes damage. Whether the age of patients with HH at the moment of their first diagnosis has an additional effect on the standard echocardiographic parameters was the aim of the study. Material and methods: We prospectively enrolled 20 HH patients, and 20 healthy age- and sex-matched volunteers. Analysis of standard echocardiographic parameters was performed and compared in subgroups of ≥50 and <50 years old (yo). Results: Comparing HH patients with healthy volunteers in ≥50 yo subgroup, significant differences were found in parameters regarding diastolic function (IVS thickness, LVM index, Em, E/Em, PV S/D, LAA index and LAV index). In the <50 yo subgroup we did not find the abovementioned differences, however LVEF appeared to be lower in the HH patients. Conclusions: Despite the lack of clinical symptoms of cardiovascular disease and the lack of deviations in the standard echocardiographic examination, there were a number of differences regarding LV diastolic function parameters in HH patients ≥50 yo, whereas differences regarding LV systolic function were more prominent in HH patients <50 yo when compared with healthy subjects.

9

Expression profile of circulating microRNAs in patients with ischemic heart failure with moderately reduced left ventricular ejection fraction – pilot study

76%

Kaufmann D., Daniłowicz-Szymanowicz L., Sakowicz-Burkiewicz M., Szwoch M., Pawełczyk T., Raczak G.

|

2019

|

vol. 1

|

issue 2

53-57

EN

Introduction Heart failure (HF) is a growing global pandemic that affects millions of people around the world. Despite the progress in medicine, diagnosis and treatment of HF remains problematic. Recently, noncoding micro ribonucleic acids called miRNAs have become significant in the diagnosis and stratification of HF risk. Aim The aim of this study was the attempt to identify the profile of circulating miRNAs specific for ischemic HF with moderately reduced left ventricular ejection fraction (HFmrEF). Methods and Results A number of changes in the miRNA profile can characterise patients with ischemic HFmrEF. This is a pilot study before further research on a larger group of patients. Conclusions Using the quantitative reverse transcription-polymerase chain reaction (qRT-PCR), serum levels of 84 miRNA were measured and compared between a patient with ischemic HFmrEF and a healthy volunteer. Analysis reveals a down-regulation of let-7f-5p and miR-1-3p, as well as up-regulation of miR-100-5p, miR-10b-5p, miR-125a-5p, miR-140-5p, miR-144-3p, miR-149-5p, miR-15b-5p, miR-183-5p, miR-208b-3p, miR-224-5p, miR-26b-5p, miR-27b-3p, miR-302a-3p, miR-320a, miR-7-5p, miR-99a-5p.

10

Comparison of clinical and echocardiographic parameters in patients with hypertrophic cardiomyopathy under and over 60 years of age

64%

Wabich E., Raczak G., Rozwadowska K., Zienciuk-Krajka A., Szymanowicz W., Kozłowski D., Kaleta A. M., Daniłowicz-Szymanowicz L.

|

2019

|

vol. 2

|

issue 1

28-35

EN

Background Hypertrophic Cardiomyopathy (HCM) is one of the most common genetic myocardial diseases. Transthoracic echocardiography which includes speckle tracking technique is tool for HCM diagnosis and monitoring the course of the disease. The aim of this study was to compare clinical and echocardiographic parameters in HCM patients older and younger than 60 years old (yo). Material and methods We prospectively enrolled 53 HCM patients, who were divided into two groups: younger and older than 60 yo. Clinical parameters, standard echocardiographic indices, as well as strain parameters were assessed and compared between the groups. Results The older subgroup was characterized by a higher prevalence of coronary artery disease. In the younger subgroup the incidence of atrial fibrillation was quite high, which occurs far more often than in the general population. Echocardiographic analysis showed worse diastolic function in older, as well as lower volume of the LV. The global longitudinal strain was worse in <60 patients. The 3D strain parameters differed significantly between the groups: the area and radial strains were worse in younger patients. Conclusions HCM patients older and younger than 60 yo differ significantly in terms of clinical and echocardiographic parameters.

11

Comparison of clinical and echocardiographic parameters in patients with hypertrophic cardiomyopathy under and over 60 years of age

64%

Wabich E., Raczak G., Rozwadowska K., Zienciuk-Krajka A., Szymanowicz W., Kozłowski D., Kaleta A. M., Daniłowicz-Szymanowicz L.

European Journal of Translational and Clinical Medicine

|

2019

|

vol. 2

|

issue 1

28-35

EN

Background: Hypertrophic Cardiomyopathy (HCM) is one of the most common genetic myocardial diseases. Transthoracic echocardiography which includes speckle tracking technique is tool for HCM diagnosis and monitoring the course of the disease. The aim of this study was to compare clinical and echocardiographic parameters in HCM patients older and younger than 60 years old (yo). Material and methods: We prospectively enrolled 53 HCM patients, who were divided into two groups: younger and older than 60 yo. Clinical parameters, standard echocardiographic indices, as well as strain parameters were assessed and compared between the groups. Results: The older subgroup was characterized by a higher prevalence of coronary artery disease. In the younger subgroup the incidence of atrial fibrillation was quite high, which occurs far more often than in the general population. Echocardiographic analysis showed worse diastolic function in older, as well as lower volume of the LV. The global longitudinal strain was worse in <60 patients. The 3D strain parameters differed significantly between the groups: the area and radial strains were worse in younger patients. Conclusions: HCM patients older and younger than 60 yo differ significantly in terms of clinical and echocardiographic parameters.

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Transesophageal three-dimensional echocardiography improves the safety of transvenous extraction of pacemaker and implantable cardioverter-defibrillator leads – preliminary report

Transesophageal three-dimensional echocardiography improves the safety of transvenous extraction of pacemaker and implantable cardioverter-defibrillator leads – preliminary report

Risk factors for poor prognosis in heart failure with particular attention to the elderly population

Clinical and laboratory assessment of patients with new-onset atrial fibrillation in acute myocardial infarction

Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

Expression profile of circulating microRNAs in patients with ischemic heart failure with moderately reduced left ventricular ejection fraction – pilot study

Clinical and laboratory assessment of patients with new-onset atrial fibrillation in acute myocardial infarction

Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

Expression profile of circulating microRNAs in patients with ischemic heart failure with moderately reduced left ventricular ejection fraction – pilot study

Comparison of clinical and echocardiographic parameters in patients with hypertrophic cardiomyopathy under and over 60 years of age

Comparison of clinical and echocardiographic parameters in patients with hypertrophic cardiomyopathy under and over 60 years of age