The present study concerns responsiveness of pre- and postsynaptic 5-hydroxytryptamine (5-HT)-1A receptors in a rat model of tardive dyskinesia (TD). Vacuous chewing movements (VCMs) in rats are widely accepted as an animal model of TD. Results show that haloperidol injected at a dose of 1 mg/kg twice a day for 5 weeks elicited VCMs, which increased in a time dependent manner following the drug administration for 3-5 weeks. Tolerance was produced in motor coordination during the potentiation of VCMs. Exploratory activity in an open field and in an activity box decreased in haloperidol treated animals. The effects of 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT; 0.5 mg/kg) were monitored 48-h after withdrawal from repeated administration of haloperidol. 8-OH-DPAT-induced locomotion was greater in haloperidol treated rats. 5-HT synthesis increased in haloperidol treated animals, while 8-OH-DPAT-induced decreases of 5-HT synthesis were greater in repeated haloperidol than repeated saline injected animals. The results suggest that an increase in the effectiveness of somatodendritic 5-HT-1A receptors may decrease the inhibitory influence of 5-HT on the activity of dopaminergic neurons to precipitate VCMs. The 5-HT-1A agonist may help to alleviate neuroleptic-induced TD.
The primary goal of the Antihydrogen Experiment: Gravity, Interferometry, Spectroscopy (AEGIS) collaboration is to measure for the first time precisely the gravitational acceleration of antihydrogen, H̅, a fundamental issue of contemporary physics, using a beam of antiatoms. Indeed, although indirect arguments have been raised against a different acceleration of antimatter with respect to matter, nevertheless some attempts to formulate quantum theories of gravity, or to unify gravity with the other forces, consider the possibility of a non-identical gravitational interaction between matter and antimatter. We plan to generate H̅ through a charge-exchange reaction between excited Ps and antiprotons coming from the Antiproton Decelerator facility at CERN. It offers the advantage to produce sufficiently cold antihydrogen to make feasible a measurement of gravitational acceleration with reasonable uncertainty (of the order of a few percent). Since the cross-section of the above reaction increases with n⁴, n being the principal quantum number of Ps, it is essential to generate Ps in a highly excited (Rydberg) state. This will occur by means of two laser excitations of Ps emitted from a nanoporous silica target: a first UV laser (at 205 nm) will bring Ps from the ground to the n=3 state; a second laser pulse (tunable in the range 1650-1700 nm) will further excite Ps to the Rydberg state.
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