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Fatal outcome of pyoderma gangrenosum with multiple organ involvement and partially responding to Infliximab

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Drinda S., Oelzner P., Codina Canet C., Kaatz M., Wolf G., Hein G.
Open Medicine
|
2006
|
vol. 1
|
issue 3
306-312
EN
Pyoderma gangrenosum is an inflammatory dermatosis of uncertain etiology, often associated with chronic inflammatory bowel or rheumatoid disease. It predominantly affects the skin. A systemic organ involvement caused by aseptic neutrophilic abscesses, however, fundamentally influences the prognosis. A patient with idiopathic pyoderma gangrenosum insufficiently responded to a conventional immune suppressive therapy and the disease proceeded aggressively. During treatment with Infliximab, partial remission was achieved intermediately. However, a recurring endocarditis, led to a lethal outcome of this patient.
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