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THE USE OF CHITIN AND CHITOSAN IN MANUFACTURING DRESSING MATERIALS

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Latańska I., Kolesińska B., Draczyński Z., Sujka W.

Progress on Chemistry and Application of Chitin and its Derivatives

2020

vol. 25

16 - 36

Despite continuous progress in the development of advanced dressing materials, there is a constant need for dressings used in an environment of infected and hard-to-heal wounds. Dressings that meet the above described requirements are products based on chitin and its derivatives. Chitosan and chitin derivative dressings are now becoming a very effective medical device in healing hard-to-heal wounds, as well as in the control of severely bleeding wounds. Chitosan and chitin are particularly valuable raw materials that accelerate wound healing processes, and they are also biocompatible and antibacterial. Dressings made of butyric-acetic chitin copolyester are intended for treating wounds of various aetiologies, including chronic wounds in which the healing process is disturbed by concomitant diseases. Materials based on chitosan are also widely used in the area of heavily bleeding and chronic wounds.

MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR CONTROLLED IBUPROFEN RELEASE

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Mucha M., Michalak I., Draczyński Z.

Progress on Chemistry and Application of Chitin and its Derivatives

2013

vol. 18

issue 18

139-147

In view of ongoing interest in biodegradable polymers, dibutyrylchitin was used as a matrix for controlled release of a model substance. Transdermal systems (films) are presently more commonly used as an alternative to standard forms of drug delivery. The presented results are concerned with the release of ibuprofen from dibutyrylchitin film. The obtained transdermal films were modified by applying a control layer to slow down the release process. The matrices were also modified by adding nanoclay (Nanofil 2). Dibutyrylchitin matrices were tested for swelling and release kinetics using UV-Vis spectrophotometer. The drug kinetics release was studied in phosphorus buffer of pH=5.5 at the temperature of 35˚C. Structural investigations of the obtained matrices were carried out by optical microscopy and FTIR spectrophotometry. An appropriate mathematical model was also fitted to the obtained experimental data

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2 Progress on Chemistry and Application of Chitin and its Derivatives

1 2020

1 2013

2 Draczyński Z.

1 Kolesińska B.

1 Latańska I.

1 Michalak I.

1 Mucha M.

1 Sujka W.

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THE USE OF CHITIN AND CHITOSAN IN MANUFACTURING DRESSING MATERIALS

MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR CONTROLLED IBUPROFEN RELEASE