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Genetic Variation as a Possible Explanation for the Heterogeneity of Pain in Tendinopathy: What can we learn from other pain syndromes?

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Mkumbuzi N. S., Posthumus M., September A. V., Collins M.

Central European Journal of Sport Sciences and Medicine

2021

vol. 36

57-72

The mechanisms of pain in tendinopathy are unclear. Current theories implicate tendon structural changes, neovascularisation, inflammation or changes in central pain processing. As with other types of musculoskeletal pain, tendon pain has high interindividual variability and, as with other types of pain, this could be attributed to genetic variation. Notably, the association between certain genetic polymorphisms and susceptibility to tendinopathy is well established in the literature. Therefore, the investigation of the mechanisms of tendon pain should also extend to include genetic variation as a possible explanation for the clinical features of tendon pain. This review summarises the current knowledge on genetic contributors to chronic pain and highlights findings that are relevant to chronic tendon pain. In particular, based on the current hypotheses on the possible sources of tendon pain, it focuses on findings that relate to genes that encode structural connective tissue components, inflammatory markers, ion channels and catecholamines and how they may relate to chronic tendon pain. In the absence of a definitive mechanism of tendon pain, an a priori genetic approach that is guided by these current hypotheses may help elucidate the mechanisms of tendon pain which may allow a more rational approach to research and treatment.

Anthropometric and physical performance characteristics in African women football players: A prospective, cross-sectional pilot study

88%

Mkumbuzi N. S., Chibhabha F., Govere F. M., Chiwaridzo M., Oulo B.

Central European Journal of Sport Sciences and Medicine

2022

vol. 40

5-15

Being injured is inherent to participating in football activities; therefore, prevention of injuries is crucial. This requires that the risk factors for injury be established. However, such studies are rarely conducted in women athletes in Africa. The study’s aim was to explore intrinsic risk factors for injury among African women football players using functional and musculoskeletal assessments. Participants (n=40) completed demographic questionnaires; upper and lower limb active range of motion (AROM); muscle endurance and functional movement screening (FMS™) assessed. Median age [Q1; Q3] was 24 [20; 27] years. Participants performed 20.5 [0; 30.5] push-ups and 28 squats [30; 38] in 60s; and held the prone elbow plank for 46.2s [30.6; 64.5]. Median FMS™ score was 12 [10; 13]; most players (n=27, 68%) could not execute a proper deep squat. Most players (70%; n=28), were able to properly perform the in line lunge but scored poorly in the shoulder mobility domain of the FMS™, with 73% (n=29) scoring ≤1. Players with a history of injury had lower FMS™ total (p=0.02). Overall, participants presented with low muscle endurance and movement imbalances, which might predispose them to injury. Hence, strength and conditioning measures should be instituted in this population to prevent injuries.

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2 Central European Journal of Sport Sciences and Medicine

1 2022

1 2021

2 Mkumbuzi N. S.

1 Chibhabha F.

1 Chiwaridzo M.

1 Collins M.

1 Govere F. M.

1 Oulo B.

1 Posthumus M.

1 September A. V.

Search results

Genetic Variation as a Possible Explanation for the Heterogeneity of Pain in Tendinopathy: What can we learn from other pain syndromes?

Anthropometric and physical performance characteristics in African women football players: A prospective, cross-sectional pilot study