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Morphological evaluation of the iliac and femoral arteries; possibilities and perspectives

100%
Dziekiewicz M., Markiewicz T., Kozłowski W., Maruszyński M.
Polish Journal of Surgery
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2015
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vol. 86
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issue 1
1-6
EN
The study presented an approach to the morphometric image of atherosclerotic lesions of the final segment of the abdominal aorta, femoral and iliac arteries, considering possible endovascular intervention. The evaluation of these arteries is very important, because they are often used as a point of access for endovascular procedures performed on the peripheral arteries, or within the thoracic and abdominal aorta and its branches, as well as coronary arteries. The aim of the study was to determine morphometric measurements describing the atherosclerotic lesions, including the methodology of their surgical interpretation. Material and methods. The study group comprised 128 tomograms of patients qualified for surgery. An algorithm based on the mathematical morphology was designed to track the vessels, starting from the division of the common femoral artery, and ending at the bifurcation of the abdominal aorta. We proposed a set of numerical measurements of the observed arterial changes. Results and conclusions. We analysed 128 tomograms with a 94.5% efficiency, and with the assessment accuracy of the degree of lumen reduction (MAE- 1.5%). We observed much higher measurement values of local tortuosity of the atherosclerotic arteries (0.3 - 1 radians), as compared to their anatomical course in a healthy subject (0 - 0.2 radians). The presented method can be a very accurate and useful tool in the numerical analysis of the lumen distribution of the arteries and atherosclerosis, dedicated to surgeons elaborating management strategies.
2
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Polymer-glue as a life and kidney function saver: a life-threatening hemorrhage in the ruptured upper pole artery of the kidney managed by percutaneous embolization - a case report and literature review

64%
Antoniewicz A., Wojtkowska I., Dziekiewicz M., Kępka C., Kremis E., Zapała Ł., Skiba R., Stępińska J.
Open Medicine
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2013
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vol. 8
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issue 3
339-342
EN
In this paper we report the case of a nearly fatal hemorrhage in the artery of the renal upper pole that occurred in a 84-year-old woman on anticoagulation treatment in connection with aortic valve replacement 4 days prior to the incident. The artery was injured during the evacuation of a hematoma of the right pleural cavity. While the patient was in the intensive care unit recovering from cardiac valve surgery, the consulting urologist was summoned in order to cope with massive hematuria and acute urine retention. Unfortunately, conservative urological management based on catherization via a three-way catheter and constant transurethral lavage with saline was unsuccessful. Angio-computed tomography revealed a ruptured branch of the renal upper pole artery. A highly selective embolization using histoacryl injection during percutaneous angioplasty was performed. There were no complications in the following days. The patient was subject to postoperative follow-up at 3, 6 and 9 months and renal scintigraphy was performed at 6 months revealing symmetrical function of both kidneys without any changes in the upper pole of the right kidney.
3
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The - 801 G/A Polymorphism ofCXCL12Promoter Gene as Unfavorable Genetic Prognosis factor involved in Colorectal Cancer

64%
Langner E., Przybyłowska K., Sygut A., Mik M., Dziki Ł., Dziekiewicz M., Majsterek I., Dziki A.
Polish Journal of Surgery
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2010
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vol. 82
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issue 8
459-463
EN
CCXL12 also called stromal derived factor-1 (SDF-1), a protein related to angiogenesis and inflammation, has been correlated with the progression of a number of malignancies. Single nucleotide - 801G/A polymorphism of CXCL12 gene has been described and is regarded as a target for cis-acting factor that has the ability to up-regulate CXCL12 expression.The aim of the study. Based on the suggested role of CXCL12 in the pathogenesis of cancer we examined the association of the gene variant CXCL12-A with colorectal cancer.Material and methods. We genotyped - 801G/A polymorphism of CXCL12 gene in 164 colorectal patients and 184 age-matched healthy subjects. Genotyping was done with PCR-RFLP.Results. There were no significant differences in the frequencies of SDF1-3'A allele, between patients and controls. The frequency of CXCL12 G/A and G/A plus A/A genotype was significantly higher in a group of patients with lymph node metastasis compared with those without metastasis.Conclusions. The CXCL12 gene G/A polymorphism was not related to colorectal cancer risk but is associated with the induction of lymph-node metastasis of colorectal cancer disease in Polish.
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