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1

Impairment of endothelial function in hypertension, possibilities of evaluation using laboratory methods

100%
Krasnowski R., Klinger M.
Postępy Higieny i Medycyny Doświadczalnej
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1996
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vol. 50
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issue 1
65-80
EN
An overview of literature data concerning the interactions between hypertension and vascular endothelium is presented. Arterial hypertension is accompanied by morphological and functional changes of endothelium. The laboratory methods measuring endothelial damage are very useful tools in evaluation of endothelium state.
2

Effect of recombinant IFN-gamma on IgE-dependent leukotriene generation by peripheral blood leukocytes in patients with pollinosis and asthma

81%
Krasnowska M., Medrala W., Malolepszy J., Krasnowski R.
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vol. 48
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issue 4
287-292
EN
Interferon gamma (IFN-gamma) is considered one of the causative and intensifying factors in inflammation. The reaction to allergens releases IFN-gamma, an immunomodulatory cytokine known to inhibit IgE synthesis and Th cell proliferation. The aim of the study was to evaluate the influence of IFN-gamma on leukotriene (LT) release in vitro, from human leukocytes of atopic patients with pollinosis and asthma. Thirty-eight patients were enrolled in the study: 15 with pollinosis and 23 asthmatics. In the presence of IL-3, leukocytes were stimulated with specific allergens. Other samples of leukocytes were preincubated with different concentrations of IFN-gamma for 15 min before allergen stimulation. The concentration of LT in supernatants was measured according to the CAST-ELISA procedure. We stated that IFN-gamma had significantly diminished LT release in a dose-dependent mode from the leukocytes of pollinotics. IFN-gamma did not change LT release in the asthmatic group, although, in leukocytes the small and medium basic production of LT, IFN-gamma caused a statistically significant fall in LT generation.
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