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Molecular aspects in the pathogenesis of human systemic lupus erythematosus

100%

Liossis S.-N. C., Tsokos G. C.

vol. 48

issue 1

11-19

Systemic lupus erythematosus is a common and often devastating systemic autoimmune disease of unknown etiology. In this communication we review the latest developments of the molecular pathogenesis of human lupus. Novel genetic studies of multiplex lupus families have revealed potential disease-associated genome intervals, put special emphasis on genetic loci mapping in the long arm of chromosome 1 and have underscored the complexity of the underlying genetic background. New data have emerged on the role of estrogens in the function of lymphocytes and a number of studies have recently emphasized the relative Th-1/Th-2 cytokine imbalance in favor of a Th-2 type cytokine immune response. Finally, novel experiments have revealed an abnormal antigen receptor- -mediated signaling process in lupus T and B cells, which may influence the aberrant expression and function of costimulatory molecules as well as of other aspects of immune cell function. It is important to decipher the underlying molecular mechanisms that govern the expression of human lupus, because we may design novel, rational approaches in the treatment of a human lupus, a disease that has high morbidity and mortality.

Emerging concepts in the molecular pathogenesis of systemic lupus erythematosus

81%

Nambiar M. P., Juang Y.-T., Tsokos G. C.

Archivum Immunologiae et Therapiae Experimentalis

2002

vol. 50

issue 1

35-46

Systemic lupus erythematosus is a prototypic autoimmune disease that predominantly afflicts women during child-bearing age. The disease is characterized by the production of autoantibodies and immune complexes in association with a diverse array of clinical manifestations. Investigation into the etiopathogenesis has been directed at identifying the genes that provide susceptibility to the disease, the complex cellular and cytokine aberrations and the biochemical abnormalities that are responsible for them. Understanding the immune cell signaling and gene transcription abnormalities will help us tailor new strategies for efficient biotherapy of the disease.

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2 Archivum Immunologiae et Therapiae Experimentalis

1 2002

1 2000

2 Tsokos G. C.

1 Juang Y.-T.

1 Liossis S.-N. C.

1 Nambiar M. P.

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Molecular aspects in the pathogenesis of human systemic lupus erythematosus

Emerging concepts in the molecular pathogenesis of systemic lupus erythematosus