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FAPA mass spectrometry of hydroxychalcones. Comparative studies with classical methods of ionization

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Smoluch M., Bartkowiak G., Reszke E., Lechowicz W., Silberring J., Schroeder G.

Current Issues in Pharmacy and Medical Sciences

2014

vol. 27

issue 1

27-31

In this paper we are focused on analysis of hydroxychalcones, i.e. 2’-hydroxychalcone, 3’-hydroxychalcone and 4’-hydroxychalcone, by the Flowing Atmospheric Pressure Afterglow mass spectrometry (FAPA-MS), and on comparison of the obtained data with other classical methods including ESI-MS, APCI, MALDI, and GC/EI-MS. The paper is presenting fragmentation pathways of both positive-, and negative hydroxychalcone ions. Tested compounds were characterized by comparison of the results (signals m/z and relative intensities) from the five mass spectrometry techniques, showing very good utility of FAPA method for fast and easy analysis of the low molecular weight compounds. Moreover, FAPA does not require a time-consuming derivatization, nor search for a suitable solvent or matrix, often incompatible with various ion sources.

Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.

100%

Zubrzak P., Kociołek K., Smoluch M., Silberring J., Kowalski M. L., Szkudlińska B., Zabrocki J.

2001

vol. 48

issue 4

1151-1154

Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3, Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile-Ψ[CN4]-Ala3, Pro3-Ψ[CN4]-Ala4 and Val6-Ψ[CN4]-Alawere synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).

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1 Acta Biochimica Polonica

1 Current Issues in Pharmacy and Medical Sciences

1 2014

1 2001

2 Silberring J.

2 Smoluch M.

1 Bartkowiak G.

1 Kociołek K.

1 Kowalski M. L.

1 Lechowicz W.

1 Reszke E.

1 Schroeder G.

1 Szkudlińska B.

1 Zabrocki J.

1 Zubrzak P.

Search results

FAPA mass spectrometry of hydroxychalcones. Comparative studies with classical methods of ionization

Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.