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Generalization of induced interhemispheric interference: a chronometric approach to one-brain vs two-brains models of the hemispheres cooperation

100%
Wolski P.
Acta Neurobiologiae Experimentalis
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1993
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vol. 53
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issue 1
251-256
EN
A reaction time study with normal human subjects was conducted to obtain support for one or the other model of interhemispheric relations - referred to as the one-system and the two-systems hypotheses. 12 subjects were extensively trained in a complex reaction time task consisting of a "priming sub-task" which introduced interhemispheric interference and two different "test sub-tasks" measuring the generalization of interference. The interference priming produced visible slowing of RT's on subsequent trials. Interestingly, the deterioration of the two test sub-tasks was alike, despite the marked difference in the amount of the interhemispheric communication they required. This result is more in line with the one-system hypothesis, as the two-systems hypothesis predicts deterioration proportional to the amount of the required interhemispheric communication.
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Deep Hypothermic Circulatory Arrest During Pulmonary Thrombendarterectomy in Patients with Chronic Thrombembolic Pulmonary Hypertension

45%
Dyk W., Wolski P., Szatkowski P., Szpakowski E., Biederman A.
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EN
Chronic thrombembolic pulmonary hypertension is a rare complication of acute pulmonary embolism. Narrowing or closure of pulmonary arteries is the cause of pulmonary hypertension and results in right ventricular overload and failure. The treatment of choice is pulmonary thrombendarterectomy. Deep hypothermic circulatory arrest is a very important factor required for complete removal of the thrombembolic material from the pulmonary arteries during the operation.The aim of the study was the evaluation of the effectiveness of the use of deep hypothermic circulatory arrest during pulmonary thrombendarterectomy in patients with chronic thrombembolic pulmonary hypertension.Material and methods. Between October 1995 and October 2006 seventy patients were operated on. All of them were operated on with the use of deep hypothermic circulatory arrest. Deep hypothermia (18-19°C), pharmacotherapy, and neuromonitoring were used as a protection of the central nervous system during circulatory arrest.Results. In fifty-seven patients out of seventy, complete thrombendarterectomy was performed (more than 75% of branches opened). The average pulmonary artery pressure and pulmonary vascular resistance were decreased, and cardiac output and index were increased. Six patients died (8.6%).Conclusions. Complete thrombendarterectomy gives significant hemodynamical improvement in patients undergoing the operation. Deep hypothermic circulatory arrest during the operation does not cause significant neurological complications. Incomplete thrombendarterectomy may be the cause of right ventricular failure and death after the operation.
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