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L-MTO-PE - a potential drug for cancer therapy

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Dzierzbicka K., Gozdowska M., Kolodziejczyk A. M.
Postępy Higieny i Medycyny Doświadczalnej
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1997
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vol. 51
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issue 2
227-236
EN
Muramyl tripeptide phosphatidylethanolamine (MTP-PE), a syntetic lipophilic analogue of muramyl dipeptide, stimulates monocytes/macrophages to kill a variety of tumor cells in vitro and in vivo. Encapsulation of MTP-PE into multilamellar liposomes (L-MTP-PE) was specifically designed for in vivo targeting to macrophages by i.v. infusion and is the only form of the drug currently available for clinical trials (CGP 19835A Lipid). L-MTP-PE is presently undergoing clinical trials in patients with recurrent osteosarcoma and melanoma. L-MTP-PE combined with other anticancer agents may thus improve long-term cure rates of patients with this diseases.
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