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Effect of Tetracarpidium conophorum nut extracts on body and organ weights of monosodium glutamate obesity-induced in albino wistar rats

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Abraham E. J., Atangwho I. J., Achukee C. K., Udoubom I. A., Abang C., Ekon I. E., Nwankwor K. C.
World News of Natural Sciences
|
2024
|
vol. 52
1-11
EN
This study aimed to assess the effect of Tetracarpidium conophorum nut extracts on body weight and organ/tissue weight in monosodium glutamate obesity- induced in Wistar rats. With the global obesity epidemic lacking an effective cure, this investigation holds significance. Twenty-five Wistar rats (15 males and 10 females) were utilized, housed in well-ventilated cages at a 3:2 female-to-male ratio Monosodium glutamate was induced in pups using intraperitoneal monosodium glutamate injections from postnatal days 2 through 10. Normal controls received saline, and all experimental animals were raised on standard rat chow until reaching a weight of ≥150g. The study encompassed five groups, each consisting of 7 animals. Groups IV, V, and VI were treated with Tetracarpidium conophorum nut extracts: ethanol whole extract (EWE), ethyl acetate extract (EAE), and ethanol residue (ER), respectively. Group III, the standard control was given 5.14g/kg of Orlistat reconstituted in normal saline. Experimental animals of groups I and II served as the normal and obese controls, respectively. After a six-week treatment period, the animals were euthanized for organ harvesting. Results indicated varying weight changes among treatment groups compared to controls. The EWE-treated group displayed a notable decrease in weight (-1.40 ± 8.42) compared to the obese control (8.29 ± 8.29). Similarly, EAE-treated animals exhibited weight reduction (-6.90 ± 12.29), as did the ER-treated group (-0.10 ± 12.22). Evidently, EWE treatment induced the most substantial weight loss. Tetracarpidium conophorum nut extracts demonstrated potential in alleviating obesity-related weight gain in the rat model.
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