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Eosinophilia-myalgia syndrom: A new illness

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Szechinski J., Borysewicz K.
Postępy Higieny i Medycyny Doświadczalnej
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1992
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vol. 46
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issue 3
319-325
EN
The eosinophilia-myalgia syndrom is a newly recognized illness that has been associated with the consmption of tryptophan products. We describe the clinical and histopathological findings and the results of biochemical analyses of tryptpphan metabolism in patients with this syndrome and the toxic-oil syndrome which took place in 1981 in Spain. Symptoms and laboratory findings are similar. Chronic phase of EMS is characterised by long-term disability, sclerodermatous skin thickening, sensimotor polyneurpathy and severe episodic myalgias. The development of the syndrome may result from a confluence of several factors including the ingestion of tryptophan exposure to agents that activate indoleamine-2,3-dioxygenase, and posibility, impaired function of the hypothalmic-pituitary-adrenal axis.
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