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Genetic models to study adult neurogenesis.

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Filipkowski R. K., Kiryk A., Kowalczyk A., Kaczmarek L.
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2005
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vol. 52
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issue 2
359-372
EN
In the central nervous system (CNS) generation of new neurons continues throughout adulthood, when it is limited to the olfactory bulb and hippocampus. The knowledge regarding the function of newly-generated neurons remains limited and is vigorously investigated using diverse approaches. Among these are genetically modified mice, most of them of knock-out type (KO). Results from 23 diverse KO mouse models demonstrate the importance of particular proteins (growth factors, nitric oxide synthases, receptors, cyclins/cyclin-associated proteins, transcription factors, etc.) in adult neurogenesis (ANGE) as well as separate it from developmental neurogenesis. These results bring us closer to revealing the function of newly generated neurons in adult brains.
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Nordic Walking w rehabilitacji choroby Parkinsona

76%
Szefler-Derela J., Suszyński K., Doroniewicz I., Kowalczyk A., Opala G., Kwiek S. J.
Annales Academiae Medicae Silesiensis
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2014
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vol. 68
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issue 5
361-367
EN
INTRODUCTION Parkinson's disease is neurodegenerative disease of the elderly, for which to this day an effective cure has not been found. Besides pharmacotherapy and Deep Brain Stimulation in PD, an increasingly supplementary treatment is exercise therapy like Nordic Walking (NW). MATERIAL AND METHODS 40 patients with PD taking part in the survey were divided into two equal groups in terms of gender and stage of the disease (II and III stage of the Hoehn and Yahr scale); the study group was subjected to 6 weeks of Nordic Walking training. The control group consists of persons without physical activity for 6 weeks. RESULTS In the NW group there was a statistically significant better improvement of the test parameters. CONCLUSIONS After the 6 week rehabilitation period, major improvement in terms of patient mobility functionality and gait parameters is visible.
PL
WSTĘP Choroba Parkinsona ( Parkinson’s disease – PD) jest neurozwyrodnieniową chorobą wieku podeszłego, na którą do dziś nie wynaleziono skutecznego lekarstwa. Oprócz stosowanej farmakoterapii coraz częściej uzupełnieniem leczenia jest terapia ruchowa, w tym trening metodą Nordic Walking (NW). MATERIAŁ I METODY Badaniem objeto 40 pacjentów z PD, których podzielono na dwie równe grupy pod względem płci oraz stopnia zaawansowania choroby (II i III stopień skali Hoehn&Yahr). Grupę badawczą poddano 6-tygodniowemu treningowi metodą NW . Grupę kontrolną stanowiły osoby bez aktywności fizycznej przez 6 tygodni. W Y N I K I W grupie NW stwierdzono znamiennie statystycznie lepszą poprawę badanych parametrów. W N I O S K I Po 6-tygodniowym okresie usprawniania widoczna jest znaczna poprawa w zakresie funkcjonalności ruchowej pacjentów oraz parametrów chodu.
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