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Evidence for the similar biochemical background for psychiatric disorders and psychoactive substances addiction

100%

Iwanicka K., Malicki D., Olajossy M.

Current Problems of Psychiatry

2014

vol. 15

issue 1

5-9

Nowadays, the effects of psychoactive substances dependence are becoming more severe and acute on the social level, so this topic of research appears in the orbit of interest to many sub-disciplines, such as psychiatry, neuropsychology, neurosciences and biochemistry. The authors conducted a literature review devoted to psychiatric disorder and addiction to alcohol and other psychoactive substances in order to present evidence for the similar biochemical and neurophysiologic background for both of the mentioned above disorders. In this paper there are presented data of animal models, neuroimaging techniques and neuropsychological tests. Moreover, the authors of this paper try to identify the possible link between personality traits (e.g. impulsivity or novelty seeking) or inborn properties of the central nervous system and the development of addiction that can gradually lead to irreversible brain changes. The authors also address the phenomena of self-medication among schizophrenic patients using regularly tobacco. In the article there is also discussed the potential application of psychostimulants in the treatment of disorders such as Attention Deficit Hyperactivity Disorder (ADHD) or narcolepsy.

Współcześnie skutki uzależnienie od substancji psychoaktywnych stają się coraz bardziej dojmujące na poziomie społecznym, dlatego ta tematyka badań pojawia się w orbicie zainteresowań wielu dyscyplin, takich jak: psychiatria, neuropsychologia, neuronauki czy biochemia. Autorzy dokonali przeglądu literatury poświęconej zagadnieniom genezy zaburzeń psychicznych, jak również uzależnienia od alkoholu oraz substancji psychoaktywnych, w poszukiwaniu dowodów świadczących o podobieństwach w etiologii na poziomie biochemicznym oraz neurofizjologicznym. W poniższym artykule przedstawione zostaną dane pochodzące z modeli zwierzęcych, technik neuroobrazowania oraz testów neuropsychologicznych. Ponadto omawiane są także związki pomiędzy niektórymi cechami osobowości takimi jak impulsywność czy poszukiwanie nowości a wrodzonymi właściwościami ośrodkowego układu nerwowego, które mogą wpływać na rozwój uzależnienia. Autorzy pochylili się także nad zagadnieniem używania wyrobów tytoniowych przez osoby chorujące na schizofrenie w kontekście samoleczenia. W poniższym artykule zostało omówione także zastosowanie substancji psychoaktywnych w leczeniu zaburzeń takich jak: zespół nadpobudliwości psychoruchowej z deficytem uwagi (ADHD) czy narkolepsja.

Prevalence of self-injury, suicidal ideation, plans and attempts in adolescents aged 13 to 19 years of age

100%

Pawłowska B., Potembska E., Zygo M., Olajossy M.

Polish Journal of Public Health

2015

vol. 125

issue 1

55-59

Introduction. Increased suicide rates, both among adults and adolescents, have been seen in Poland over recent years. Aim. The aim of the study was to determine the prevalence of self-injury, suicide ideation, plans and attempts in adolescents aged 13 to 19 years. Material and methods. The study encompassed the total number of 6883 individuals aged 13 to 19 years, 69% of them being girls and 31% - boys. All respondents lived in Lubelskie Province. The research was conducted using a questionnaire designed by the authors. Results. In the group composed of 6883 adolescents living in Lublin Province, suicide ideation was reported by 47.65% of the respondents, suicide plans by 32.35%, suicide attempts were carried out by 10% of adolescents and self-injury by 24.91% of the respondents aged 13 to 19 years. Conclusions. The greatest prevalence of suicide ideation, plans and attempts, as well as self-injuries, were recorded in the group of adolescents aged 17. The adolescents living in the urban areas are more likely to inflict self-injury than those living in rural areas. Furthermore, adolescents with suicidal tendencies, e.g. attempting suicide and self-injury, are more prone to alcohol and substance abuse. It needs emphasizing that many adolescents with suicidal tendencies, compared against those who did not carry them out, have past experience of psychological, physical and sexual violence in the family, have been raised by a single parent or in families, where one of the parents abused alcohol.

Bipolar affective disorder: A review of novel forms of therapy

88%

Dziwota E., Drapala B., Gaj M., Skoczen N., Olajossy M.

Current Issues in Pharmacy and Medical Sciences

2015

vol. 28

issue 2

105-110

Normothymic, antidepressant and antipsychotic pharmaceutics are, in accordance with international guidelines, employed both in the therapy and the prevention of bipolar disorder (BD). Long-term studies on the mechanisms of action of such medications, as well as on the pathogenetic background of BD, have led to the discovery of effective, albeit unconventional pharmacotherapeutic approaches. These methods have the potential to successfully treat mania and depression, as well as to counter affective episode relapse. Allopurinol - commonly used to treat gout, secondary hyperuricemia and Lesch-Nyhan syndrome, acts by inhibiting the synthesis of uric acid, levels of which are often increased in manic patients. Due to this, an evaluation of the potential effect of allopurinol on the reduction of mania symptoms seems to be reasonable. Additionally, the numerable research papers coming out of research regarding the role of purine neurotransmitters in mood alterations, indicate that adenosine agonists act analogously to dopamine antagonists. N-acetylcysteine (NAC), a supporting agent in the pharmacotherapy of depressive episodes in bipolar disorder, substantially accelerates mood stabilization in patients. In turn, memantine, known for its procognitive effect, not only has antimanic and normothymic properties, but also boosts the neuroprotective action of traditional lithium therapy. In view of the latest opinions, the subtle pro-inflammatory process is typical for the pathophysiology of bipolar disease. Acetylsalicylic acid (ASA) (a popular analgesic, antipyretic and antiphlogistic agent) may be useful in BD therapy. This is because that, via its effect upon cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), ASA modulates leukocyte recruitment in neuro-inflammation. Apart from the above-mentioned medications, this article introduces the results of recent investigations of ketamine, modafinil and tamoxifen, including their receptor mechanisms, as well as certain genetic aspects or elements of their pharmacodynamics, for use in BD therapy. We put forward that, possibly, more insightful cognition of these drugs will allow significant enrichment in the range of pharmacotherapy for BD in the near future.

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1 Current Issues in Pharmacy and Medical Sciences

1 Current Problems of Psychiatry

1 Polish Journal of Public Health

2 2015

1 2014

3 Olajossy M.

1 Drapala B.

1 Dziwota E.

1 Gaj M.

1 Iwanicka K.

1 Malicki D.

1 Pawłowska B.

1 Potembska E.

1 Skoczen N.

1 Zygo M.

Search results

Evidence for the similar biochemical background for psychiatric disorders and psychoactive substances addiction

Prevalence of self-injury, suicidal ideation, plans and attempts in adolescents aged 13 to 19 years of age

Bipolar affective disorder: A review of novel forms of therapy