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Układ krążenia a zaburzenia psychopatologiczne

100%
Bidzan L.
Geriatria
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2012
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vol. 6
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issue 4
249-253
EN
In this work relations between the circulatory system and emotional factors are discussed. There is a close correlation between the mental state and the cardiovascular system. Psychological factors trigger numerous circulatory system symptoms. Especially chronic states of emotional tension may result in permanent circulatory system changes. Meanwhile, there is an inverse correlation, too Some of the psychopathological symptoms, especially anxiety, may be a significant signal of existing circulatory system disorders. In this thesis some of the mechanisms connecting the psyche with cardiologic factors are discussed. Another important issue in discussing the relation between the mental state and the cardiovascular system, is the administered pharmacotherapy, both psychiatric and cardiologic. Geriatria 2012; 6: 249-253.
PL
W pracy wskazano na związki układu krążenia z czynnikami emocjonalnymi. Istnieje ścisła zależność pomiędzy stanem psychicznym a układem sercowo- naczyniowym. Czynniki psychiczne wywołują wiele objawów ze strony układu krążenia. Szczególnie długotrwałe stany napięcia emocjonalnego mogą powodować trwałe zmiany w układzie krążenia. Jednocześnie istnieje zależność odwrotna. Niektóre z objawów psychopatologicznych, szczególnie lęk, mogą być istotnym sygnałem świadczącym o zaburzeniach układu krążenia. W opracowaniu omawia się niektóre z mechanizmów łączących sferę psychiczną z czynnikami kardiologicznymi. Osobnym, ważnym zagadnieniem przy omawianiu związków pomiędzy stanem psychicznym a układem sercowo-naczyniowym jest prowadzona farmakoterapia, tak psychiatryczna, jak i kardiologiczna. Geriatria 2012; 6: 249-253.
2
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USE OF VALPROIC ACID FOR THE TREATMENT OF NEUROPSYCHIATRIC SYMPTOMS IN ACQUIRED BRAIN INJURIES

100%
Bidzan L.
Acta Neuropsychologica
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2020
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vol. 18(3)
357-366
EN
Acquired brain injuries are often accompanied by a series of neuropsychiatric disorders. A wide range of pharmacological agents are used to treat neuropsychiatric symptoms. However, a more indepth review of the agents used indicates that there are in fact relatively few procedures recommended for use. Anticonvulsants including valproic acid, are of particular interest. This research aimed to assess the efficacy and safety of valproic acid, as based on a naturalistic observation of patients with various forms of acquired brain injury and who had displayed neuropsychiatric symptoms. The study group consisted of individuals (N = 43) who were treated with valproic acid as the first choice of drug. Both the initial dose and its size during further treatment, as well as the treatment method, were determined based on medical indications. The mental state of the patients was assessed twice: at the time of enrolment for the study and after 12 months. The Cohen-Mansfield Agitation Inventory (CMAI) was used for the assessment. In addition, the degree of cognitive dysfunction was assessed during the baseline study using the MMSE scale. Eventually, 24 individuals were accepted for statistical analysis. They were re-examined after 12 months and took only valproic acid during that period. 24 out of 43 individuals qualified for the study completed the 12-month observation period. 11 respondents were excluded from the study due to their inappropriate tolerance. The reported side effects were of a temporary nature (except for hair loss) and of a mild or moderate intensity. It was observed that aggressive and impulsive behaviours were significantly reduced in the study group. The positive therapeutic effect concerned all categories in the CMAI scale, except for verbal aggression. The therapeutic effect of the valproic acid was varied depending on the degree of cognitive impairments. Statistical significance for higher MMSE scores was obtained only for the category of non-aggressive verbal disorders. On the other hand, in the case of lower MMSE scores a significant reduction was observed both in the categories of non-aggressive and aggressive physical behaviours, as well as for the overall CMAI scale result. The results obtained seem to indicate a satisfactory efficacy and acceptable tolerance of valproic acid in the treatment of the neuropsychiatric symptoms accompanying acquired brain injuries.
3
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Clinical and demographic features of acutely hospitalised schizophrenia patients according to Toxoplasma gondii serostatus

51%
Grabowski J., Waszak P. M., Przybylak M., Bidzan L.
European Journal of Translational and Clinical Medicine
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2023
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vol. 6
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issue 1
14-24
EN
Background: Few data exist concerning the clinical correlates of Toxoplasma gondii infecotin in persons with schizophrenia. The aim of this study was to invesgtiate the correlaotin between toxoplasmosis and schizophrenia regarding the quality of life, symptoms and course of hospitalisaotin in paetints with schizophrenia. Methods: Acutely hospitalised paetints (n = 67) were examined twice during their hospital stay. Schizophrenia psychopathology, quality of life, extrapyramidal symptoms and T. gondii anbtiody ttires were assessed upon admission and at discharge. Results: Toxo-IgG (+) paetints (59.7%) were older, less educated, more obese and less eager to undertake psychotherapy. Female gender and higher ferltiity were dominant in this group with abnormal involuntary movements more commonly observed. Lower anptisychocti drug doses and monotherapy were used more frequently for Toxo-IgG (+) paetints. Lower educaotin (OR 2.41, 95% CI 1.21-4.79) was the most important factor associated with higher likelihood of IgG seroposivtiity. High levels of Toxo-IgM anbtiodies correlated with lower quality of life (r = -0.37; p = 0.02) and more severe posivtie (r = 0.40; p = 0.01) and focal (r = 0.32; p = 0.04) schizophrenia symptoms. Conclusions: Toxoplasmosis is more common in older, obese women with lower educaotin. Recent infecotin is linked to more severe schizophrenia symptoms. Patients with toxoplasmosis history were given less medication. Grabowski J, Waszak P, Przybylak M, Bidzan L. Clinical and demographic features of acutely hospitalised schizophrenia patients according to Toxoplasma gondii serostatus. Eur J Transl Clin Med. 2023;6(1):14-24.
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Relation of cigarette smoking and mood disorders to cognitive impairment progression

51%
Grabowski J., Przybylak M., Piasecki T., Bidzan L.
European Journal of Translational and Clinical Medicine
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2020
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vol. 3
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issue 2
29-36
EN
Background: Both depressive disorders and nicotine use are proven and important risk factors of dementia. The purpose of this study was to verify if cigarette smoking and depression symptoms together are disadvantageous for the prognosis in mild cognitive impairment. Material and methods: A total of 43 patients with a diagnosis of mild cognitive impairment were included in the study. ADAS-Cog was performed upon inclusion in the study and again at least 2 years later. Additionally, patients with ≥18 points in MADRS were qualified as depressive. The Fagerström scale for nicotine dependence was administered to smokers. Results: Our study shows a relation between severity of depressive symptoms and further deterioration of cognitive functions according to ADAS-cog scale. Regression analysis revealed that smoking associated with severity of depressive disorders is also correlated with the progression of cognitive impairment. Conclusions: The results of our study are based on a small number of subjects and should be regarded as early findings. Moreover, nicotine dependency should not be regarded as an isolated factor affecting mood disorders and cognitive impairment progression. Further studies on larger groups of patients and using more sensitive methods of cognitive function assessment are needed.
5
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Use of antihistamines for COVID-19 vaccine recipients with risk of anaphylaxis

45%
Grabowski J., Wolff M., Pettersson S. D., Brancewicz T., Bidzan L.
European Journal of Translational and Clinical Medicine
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2022
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vol. 5
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issue 1
8-11
EN
Allergic reactions to COVID-19 vaccine ranging from mild to severe have been reported in patients with a history of anaphylaxis. Currently, no guidelines are available regarding prevention of allergic reactions in patients with high-risk of anaphylaxis who plan on receiving the SARS-CoV-2 vaccine. In this case-series study, two patients with a history of anaphylaxis had taken antihistaminic drugs prior to their BNT162b2 vaccinations and experienced no major allergic reactions afterwards. The use of antihistamines prior to COVID-19 vaccination may have affected the outcome of the two subjects with history of anaphylaxis history. However, further studies are needed to evaluate efficacy, generalizability and safety of the approach presented in this case-series.
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