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Human mitochondria in health, disease, ageing and cancer

100%

Bartnik E., Lorenc A., Mroczek K.

Journal of Applied Genetics

2001

vol. 42

issue 1

65-71

In every human cell there are hundreds of mitochondria, which are required for oxidative phosphorylation as well as many other metabolic processes. Each mitochondrion contains approximately 5 mitochondrial DNA molecules. These circular DNAs of 16.5 kb in size contain only 39 genes . Mutations in mitochondrial DNA are responsible for many diseases. Alterations in these molecules may also play a role in ageing and in tumour formation.

MELAS as an example of a mitochondrial disease

88%

Piechota J., Mroczek M. K., Mroczek K., Bartnik B. E., Bartnik E.

Journal of Applied Genetics

2001

vol. 42

issue 3

351-358

MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) is a disease mainly due to a mutation at position 3243 (A G) in the leucine tRNA gene in mitochondrial DNA. Symptoms of the disorder are complex and the exact pathogenesis is not understood. A review of the literature on the subject is presented.

Root Canal System Analysis with a Group of First Permanent Molars of Upper and Lower Jaw

76%

Mroczek K., Kurzydłowski K. J., Szlązak K., Jodkowska E., Jaroszewicz J., Święszkowski W.

Archives of Metallurgy and Materials

2014

issue 2

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2 Journal of Applied Genetics

1 Archives of Metallurgy and Materials

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2 2001

3 Mroczek K.

2 Bartnik E.

1 Bartnik B. E.

1 Jaroszewicz J.

1 Jodkowska E.

1 Kurzydłowski K. J.

1 Lorenc A.

1 Mroczek M. K.

1 Piechota J.

1 Szlązak K.

1 Święszkowski W.

Search results

Human mitochondria in health, disease, ageing and cancer

MELAS as an example of a mitochondrial disease

Root Canal System Analysis with a Group of First Permanent Molars of Upper and Lower Jaw