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Elimination of Magnetic Nanoparticles with Various Surface Modifications from the Bloodstream in vivo

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Tomasovicova N., Khmara I., Koneracka M., Zavisova V., Kubovcikova M., Antal I., Kovac J., Muckova M., Kopcansky P.

Acta Physica Polonica A

2017

vol. 131

issue 4

1159-1161

The magnetic nanoparticles with the core diameter 10 nm stabilized by sodium oleate and bovine serum albumin in phosphate buffer have been modified by different biocompatible substances such as poly(ethylene glycol) (PEG), dextran (DEX), and polyvinylpyrrolidone (PVP). Prepared biocompatible magnetic fluids were characterized to obtain the particle size distribution using scanning electron microscopy and the dynamic light scattering method. To study the elimination of different modified magnetic nanoparticles from bloodstream, the biocompatible samples were applied intravenously to the mice bloodstream with further blood specimens collecting in given time intervals. Magnetic moment of the lyophilized blood samples was measured by SQUID magnetometer. Time dependence of magnetic moment of magnetic nanoparticles and magnetic nanoparticles modified by DEX, PEG and PVP normalized to the Fe₃O₄ showed that the circulation time of magnetic nanoparticles in the bloodstream depends on the substance used for modification. The unmodified magnetic nanoparticles were trapped by reticuloendothelial system within 1 h while magnetic nanoparticles modified by DEX, PEG and PVP circulated in blood up to 3 h.

Preparation and Characterization of Magnetic Nanoparticles

81%

Khmara I., Kubovcikova M., Koneracka M., Kalska-Szostko B., Zavisova V., Antal I., Rajnak M., Dankova Z., Kavecansky V., Omastova M., Kopcansky P.

Acta Physica Polonica A

2018

vol. 133

issue 3

704-706

The magnetic nanoparticles with core diameter 10 nm were modified by poly-L-lysine to bind antibody for cancer cell detection. Prepared biocompatible magnetic fluid (MFPLL) was characterized by dynamic light scattering method to obtain the particle size distribution. The microstructure of the MNPs and MFPLL samples were studied by transmission electron microscopy, X-ray diffraction and Mössbauer spectroscopy. Magnetic properties of the samples were measured by SQUID magnetometer and superparamagnetic behaviour of the samples was confirmed.

Effect of BSA Protein on the Contrast Properties of Magnetite Nanoparticles during MRI

81%

Strbak O., Kubovcikova M., Baciak L., Khmara I., Gogola D., Koneracka M., Zavisova V., Antal I., Masarova M., Krafcik A., Kopcansky P., Dobrota D., Frollo I.

Acta Physica Polonica A

2017

vol. 131

issue 4

1102-1104

The aim of the study was to establish whether there is a significant change in the MRI contrast of magnetite nanoparticles, after BSA protein binding on the surface of particles. The rationale is the applicability of this feature in clinical practice for the tracking of specific proteins which are often associated with various pathologies. Contrast agents could bind to this specific marker, with the change in MRI contrast indicating the presence of pathology. We found that changes in relative contrast acquired at low-field MRI offer potential for the differentiation of magnetite nanoparticles with and without BSA protein. However, the variations in the transverse relaxation time (T₂) and transverse relaxivity (r₂), acquired at high-field MRI, were too small to be applicable for biomedical applications.

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3 Acta Physica Polonica A

1 2018

2 2017

3 Antal I.

3 Khmara I.

3 Koneracka M.

3 Kopcansky P.

3 Kubovcikova M.

3 Zavisova V.

1 Baciak L.

1 Dankova Z.

1 Dobrota D.

1 Frollo I.

1 Gogola D.

1 Kalska-Szostko B.

1 Kavecansky V.

1 Kovac J.

1 Krafcik A.

1 Masarova M.

1 Muckova M.

1 Omastova M.

1 Rajnak M.

1 Strbak O.

1 Tomasovicova N.

Search results

Elimination of Magnetic Nanoparticles with Various Surface Modifications from the Bloodstream in vivo

Preparation and Characterization of Magnetic Nanoparticles

Effect of BSA Protein on the Contrast Properties of Magnetite Nanoparticles during MRI