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1
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Precyzyjne elementy retencyjne stosowane w protezach overdentures w żuchwie wspartych na śródkostnych wszczepach dentystycznych

100%
Błądek–Grzelczak K., Sporny S.
Folia Medica Lodziensia
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2012
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vol. 39
|
issue 1
51-69
EN
Many years of research on implants, safer surgical procedures and modern laboratory techniques have resulted in recent years, in the widespread use of overdentures supported by endosteal implants. The aim of this study is to review the retention elements available for use in mandibular overdentures supported by implants. The paper presents a brief description of the most popular precision retentive elements, such as: ball attachments, bars, magnets, telescopic crowns. The advantages and disadvantages of different prosthetic solutions have been examined. High wearing comfort of overdentures prostheses supported on implants and a significant improvement of quality of life for patients using this type of prosthesis have been highlighted.
PL
Wieloletnie badania nad wszczepami, coraz bezpieczniejsze procedury chirurgiczne i nowoczesne techniki laboratoryjne spowodowały w ostatnich latach upowszechnienie się protez nakładkowych wspartych na wszczepach śródkostnych. Celem pracy jest przegląd typów precyzyjnych elementów retencyjnych stosowanych w protezach overdentures wspartych na śródkostnych wszczepach dentystycznych. Przedstawiono krótką charakterystykę najczęściej stosowanych elementów retencyjnych, takich jak: zaczepy kulkowe, belki, magnesy i korony teleskopowe. Omówiono wady i zalety poszczególnych rozwiązań protetycznych. Zwrócono uwagę na wysoki komfort noszenia protez overdentures wspartych na wszczepach i znaczną poprawę jakości życia pacjentów użytkujących ten typ protez.
2
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Jednostronny brak skrzydłowy w żuchwie jako problem implantologiczno-protetyczny – opis przypadku

100%
Błądek–Grzelczak K., Sporny S.
Folia Medica Lodziensia
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2012
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vol. 39
|
issue 1
71-84
EN
The aim of this article is to present the case of restoring unilateral missing posterior teeth in the mandible using implants supported bridges. The patient smoked cigarettes, suffered from diabetes and hypertension. These systemic factors increase the risk of implant loss. In the shown case the success has been achieved despite the existing risk factors.
PL
W artykule opisano leczenie implantoprotetyczne pacjenta z jednostronnym brakiem skrzydłowym w żuchwie. Plan leczenia obejmował wykonanie mostu wspartego na wszczepach śródkostnych. Pacjent cierpiał na cukrzycę typu II, nadciśnienie oraz palił duże ilości papierosów, co powodowało pogorszenie rokowania. W opisywanym przypadku osiągnięto sukces terapeutyczny mimo istniejących czynników ryzyka ograniczających pozytywne prognozy.
3
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Synchronous occurrence of multiple focal nodular hyperplasia and huge hepatic Perivascular epithelioid cells tumor (PEComa) in young woman after oral contraceptive use – is there a common pathogenesis?

71%
Durczyński A., Hogendorf P., Szymański D., Sporny S., Strzelczyk J.
Polish Journal of Surgery
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2012
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vol. 84
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issue 9
457-460
EN
The association of focal nodular hyperplasia (FNH) and various neoplasms was described, but coincidence of multiple FNH and hepatic perivascular epithelioid cells tumor (PEComa) has not been reported. The clinical debate of oral contraceptive (OC) influence on FNH growth is ongoing, but no evidence exists about association of hepatic PEComa with OC use. Herein, we report a case of two FNH lesions and huge (150x100x80 mm) left hepatic lobe PEComa that occurred simultaneously in 18-year-old female with previous two year history of OC use, who underwent left hemihepatectomy and right hepatic FNH enucleation. Up to date, the patient has been followed-up for 65 months and remained disease-free. FNH and PEComa have a common vascular cytogenetic denominator. Our case raising a question of a causal relationship of FNH and PEComa with OC use that might be attributed to vascular changes. Future researches of larger sample sizes should further address this issue.
4
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Clinical Experience in Surgical Treatment of Gastrointestinal Neuroendocrine Tumors

61%
Durczyński A., Sporny S., Szymański D., Nowicki M., Hogendorf P., Strzelczyk J.
Polish Journal of Surgery
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2010
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vol. 82
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issue 4
212-218
EN
Gastroenteropancreatic neuroendocrine tumors (GEP NET) represent heterogenous group of very rare neoplasms. Nevertheless, these tumors have been increasingly diagnosed recently. Authors present own experience with surgical treatment of gastrointestinal neuroendocrine tumors.The aim of the study was to analyse retrospectively own material of patients with gastrointestinal neuroendocrine tumors treated surgically in the Department of General and Transplant Surgery of Medical University in Łódź.Material and methods. The analysis included all patients with neuroendocrine tumors surgically treated from January 2007 to June 2009 in the Department of General and Transplant Surgery of Medical University in Łódź. The clinical patients data were obtained from medical histories, operative protocols and outcomes of final histopathological examinations. Analyzed data were as follows: age, gender, type and localization of tumor, clinical signs, results of preoperative tests and type of surgical procedure.Results. Analysis revealed that 17 patients were operated on for gastrointestinal neuroendocrine tumors between years 2007-2009 in the Department of General and Transplant Surgery. Foregut tumors (5 gastric neuroendocrine tumors and 4 pancreatic insulinomas), midgut tumors (1 neuroendocrine cancer of ascending colon, 3 hepatic neuroendocrine cancers metastases, 2 primary hepatic neuroendocrine cancers, 1 gall bladder neuroendocrine cancer) and hindgut tumors (neuroendocrine cancer of rectum) were diagnosed in nine cases (53%), in seven cases (41%) and in one case (5%), respectively. Wide range of surgeries were performed in the Department, as follows: in 2 cases right hemihepatectomy, in 3 cases extended right hemihepatectomy, in 1 case left hemihepatectomy, in 4 cases pancreatic tumor enucleation, in 2 cases gastric resection, in 3 cases gastrectomy, in 1 case right hemicolectomy and in 1 case anterior resection of the rectum. The vast majority (11/17 patients; 64%) of tumors were poorly-differentiated neuroencorine carcinomas with high grade of histological malignancy. In one case coincidence of insulinoma and nesidioblastosis was confirmed. One patient suffered from signs of neuroglycopenia with loss of consciousness and convulsion preoperatively, incorrectly diagnosed as epilepsy.Conclusions. Treatment of patients with gastrointestinal tumors is complex process and most commonly require close cooperation of various proffesional clinicians. Since asymptomatic course of disease and late stage of tumor advancement at diagnosis, technically difficult operations are often essential. Thus, surgeon who perform operations of patients with neuroendocrine tumors should be well experienced in carring out extensive surgical procedures.
5
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Celecoxib - A Selective Cyclooxygenase-2 Inhibitor Exhibits Dose - Dependent Chemopreventive Activity on an Animal Model of Colorectal Cancer*

61%
Spychalski M., Dziki Ł., Buczyński J., Kulig A., Sporny S., Dziki A.
Polish Journal of Surgery
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2008
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vol. 80
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issue 5
248-255
EN
Colorectal cancer (CRC) is still one of the unresolved issues in medicine. Despite constant improvements in diagnosis and treatment, the prognosis for CRC is unsatisfactory. In recent years, much attention has been paid to experiments concerning chemoprevention of CRC.The aim of the study was evaluation of the effectiveness of celecoxib, a selective Cyclooxygenase-2 (COX-2) inhibitor of chemically-induced CRC carcinogenesis in Fisher F344 rats.Material and methods. Forty-five four-week old male F344 rats were randomized into four groups. In Groups 1, 2, and 3, we induced the CRC carcinogenesis through two subcutaneous injections of Azoxymethane in doses of 20 mg/kg. Rats from groups 1 and 2 were treated with celecoxib in doses of 10 and 30 mg/kg from the start of the experiment. Group 4 was a negative control. The experiment ended in the 26th week. We assessed the following parameters: the number of Aberrant Crypt Foci (premalignant lesions in colons) and the immunoexpression indexes: COX-2, Vascular Endothelial Growth Factor (VEGF), and c-myc.Results. Celecoxib reduced the ACF number. The ACF reduction was dose-dependent. The median ACF number per field of vision was as follows for each of the groups: 1.7, 0.75, 3.2, and 0.2. Celecoxib, irrespective of the dose, reduced the VEGF immunoexpression index. We did not observe a reduction of COX-2 or c-myc immunoexpression in the celecoxib groups.Conclusions. In this experiment, we proved that celecoxib possessed chemopreventive activity. Carcinogenesis inhibition by selective COX-2 inhibitor was dose-dependent. We demonstrated that celecoxib hidners angiogenesis, expressed as VEGF immunoexpression. We indirectly confirmed the hypothesis of a celecoxib COX-2 independent pathway mechanism of action.
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