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Locomotor recovery after thoracic spinal cord lesions in cats, rats

100%
Majczynski H., Slawinska U.
Acta Neurobiologiae Experimentalis
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2007
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vol. 67
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issue 3
235-257
EN
More than a hundred years of extensive studies have led to the development of clinically valid animal models of spinal cord injury (SCI) used to investigate neurophysiological mechanisms, pathology and potential therapies. The cat and rat models of SCI were found particularly useful due to several behavioral responses that correspond to clinical symptoms seen in patients. This review concentrates on recovery of motor behavior in the rat and cat models of thoracic spinal cord injury. At the beginning an outline of the general concept of neural control of locomotion: the existence of a spinal network producing the locomotor activity and the supraspinal and sensory inputs that influence this network is presented. Next, the severity of functional impairment in relation to the extent and precise location of lesions at the thoracic level in cats and rats is described. Finally, the impact of animal studies on the treatment of SCI patients and the possibility that a spinal network producing the locomotor activity also exists in humans is discussed.
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Overground locomotion in intact rats: contact electrode recording

81%
Gorska T., Majczynski H., Zmyslowski W.
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vol. 58
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issue 3
227-237
EN
The aim of the experiments was to check the validity of the method of contact electrodes for studying overground locomotion in the rat. The basic indices of locomotion, obtained in 7 intact rats with at least 100 steps recorded in each, were analysed and compared with those described by other authors using different methods of movement recording. It was found that the method of contact electrodes gives reproducible and reliable results and may thus be used in further experiments of rat locomotion after CNS lesions.
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Different forms of impairment of the fore-hindlimb coordination after partial spinal lesions in cats

81%
Gorska T., Bem T., Majczynski H., Zmyslowski W.
Acta Neurobiologiae Experimentalis
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1996
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vol. 56
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issue 1
177-188
EN
Effects of large low thoracic (T10-T11) partial spinal lesions involving either the ventral quadrans of the spinal cord and, to a different extent the dorsolateral funiculi, or different extent of the lateral funiculi and/or the dorsal columns, on the fore-hindlimb coordination were examined in cats walking overground at moderate speeds. In both groups of operated cats, except those in which the lesion was essentialy confined to dorsal columns, three different forms of impairment of fore-hindlimb coordination were observed, depending on the extent of lesion: (1) a change of locomotion towards pacing with preservation of the equality of the rhythms in the fore- and the hindlimbs; (2) episodes of fore- and hindlimb rhythm dissociation and (3) a permament dissociation of the fore- and hindlimb rhythms. A comparison of the results obtained in these two groups operated cats points to the more important role played by lateral funiculi, then by other parts of the spinal white matter, in controlling the fore-hindlimb coordination in cats.
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