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Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties

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Framski G., Wawrzyniak D., Jahnz-Wechmann Z., Szymanska-Michalak A., Kraszewski A., Barciszewski J., Boryski J., Stawinski J.
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2016
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vol. 63
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issue 4
765-771
EN
Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.
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