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Effects of low doses of gamma rays on the stability of normal and diabetic erythrocytes

100%
Kaczmarska M., Kopyściańska Z., Fornal M., Grodzicki T., Matlak K., Korecki J., Burda K.
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2011
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vol. 58
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issue 4
489-496
EN
We studied the influence of low doses of γ radiation (from 0.04 to 1.8 mGy) on the stability of human red blood cells (RBC) from healthy donors and diabetic patients using absorption spectroscopy. Because of the alteration of many enzymatic pathways in diabetic RBCs resulting in strong modification of the lipid and protein membrane components one could expect that the ionizing γ-radiation should influence the stability of the healthy and diabetic cells in a different way. Indeed, distinct discontinuities and monotonic changes of hemolysis detected in the healthy and diabetic RBCs suggest that various enzymatic and chemical processes are activated in these membranes by γ radiation. Mössbauer measurements showed that only the highest applied dose of γ radiation caused modification of hemoglobin in both types of RBCs.
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Trauma in the Aged

84%
Brongel L., Hładki W., Grodzicki T., Friedlein J., Nazimek R., Lorkowski J., Kuliś M., Budzyński P.
Polish Journal of Surgery
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2007
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vol. 79
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issue 2
106-112
EN
After accidents, elderly patients (aged 75 years and older) have been demonstrated to have increased mortality rates after trauma, however, the prognosis of those patients surviving their hospitalization is unknown. We hypothesized that surviving elderly patients would also have decreased functional outcomes.The aim of the study. This study examined the outcome of elderly patients exposed to varying trauma relative to all trauma patients.Material and methods. This was a retrospective study of 5046 patients with trauma in 2001-2005 treated. 972 of these patients were aged 75 or more. Data included demographics, risks factors, cause of trauma, operative or conservative management and result of treatment.Results. Mechanisms of injury were falls (almost 90%), motor vehicle collisions (8%) and other. Statistical differences in the mechanisms of trauma between the studied and younger groups were observed. The mortality rate was doubled in the older group. Almost 2/3 of the patients underwent surgery. The strategy of management and treatment of elderly trauma patients has not been studied in the literature. This group may require special management and monitoring, and if possible, noninvasive modes of treatment. There are big advantages by aggressive, operative treatment of oldest patients, but is the "thin red line" in profits and loss in this group.Conclusions. In our opinion, it is necessity to operate on all elderly patients in good overall condition who were mobile and of good mental status prior to the accident, status, but we do not recommend operations in low-risk patients or those with bad prognosis for successful rehabilitation.
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