Search results

Sort By:

Limit search:

Students’ knowledge about cervical cancer and vaccine against human papillomavirus (HPV)

100%

Maksimiuk M., Sobiborowicz A., Beranek O., Sobol M., Badowska-Kozakiewicz A. M.

vol. 8

issue 4

127-136

Introduction: Human papillomavirus (HPV) is the most common sexually transmitted virus worldwide. It’s associated with over 99% of cases of cervical cancer and also connected with other cancers like rectal, vaginal or penile. Aim: To evaluate the level of knowledge about cervical cancer and HPV vaccine among students attending medical and non-medical universities and to discuss problems connected with low interest in cancer prevention. Materials and methods: 427 students took part in the anonymous survey. Original questionnaire consisted of 19 questions and was prepared by the authors powered by review of valid references. Results: 93.2% of interviewees have heard about HPV vaccine and 20.6% of them have been vaccinated. There was a statistically significant difference in knowledge and attitude to vaccination and cancer prevention between medical and non-medical students. Discussion: Interviewees are aware of hazards involved in HPV infection, but they don’t know the exact scale of it. They cannot evaluate the risks connected with cervical cancer properly, what may influence their low interest in prevention. Knowledge about HPV vaccine’s existence is common, but there is a huge disinformation about its characteristics and side effects. Main source of knowledge are mass media, subject of vaccination is discussed at school or with general physician extremely rarely. The price of the vaccine is main reason for resignation, so regional government’s prevention programs play a very important role. Conclusions: The education of the society is a strong base for excellent prevention of cancers. Doctors should be included in more active operations for cervical cancer prevention

ELF3 as an important factor in carcinogenesis – a brief review of the recent studies

86%

Domańska J., Poboży K., Kuryłek M., Fudalej M. M., Sobiborowicz A., Deptała A., Badowska-Kozakiewicz A. M.

Introduction and objective: E74-like transcription factor 3 (ELF3) is mainly expressed in epithelial tissue, being responsible for differentiation and regeneration. Furthermore, it plays a role in inflammation, remodeling, allergy regulation and apoptosis. Various studies on ELF3 conducted since 1997 have also proved its connection with carcinogenesis and metastasis. This review summarizes recent advances in understanding the role of ELF3 in the following cancers: ampullary, bladder, breast, gastric, hepatocellular, nasopharyngeal, thyroid, lung and ovarian ones. State of knowledge: There are still many unresolved and undiscovered issues regarding ELF3 mutations, however, based on research since 2016, a link to many signaling pathways important for carcinogenesis has been shown. There is no simple correlation between a specific ELF3 mutation and effect on cancer cells. In various types of cancers, ELF3 is associated with other pathways, and modifications exerted by silencing or amplifying its or associated genes, cause different effects in patient prediction. An example of the effect of ELF3 on tumor progression is achieved by negatively regulating the ZEB1 transcription factor responsible for metastasis. WNT, RAS, Akt, mTOR, HER2, Cyclin D, IRF6 are other ELF3-related factors that affects pathways crucial for tumorigenesis. Conclusions: Further research and attempts to use ELF3 in the treatment and prognosis of cancer appear to be beneficial.

Refine search results

2 OncoReview

1 2020

1 2018

2 Badowska-Kozakiewicz A. M.

2 Sobiborowicz A.

1 Beranek O.

1 Deptała A.

1 Domańska J.

1 Fudalej M. M.

1 Kuryłek M.

1 Maksimiuk M.

1 Poboży K.

1 Sobol M.

Search results

Students’ knowledge about cervical cancer and vaccine against human papillomavirus (HPV)

ELF3 as an important factor in carcinogenesis – a brief review of the recent studies