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  1. 1 Open Medicine

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  1. 1 2008

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  1. 1 Seydlová G.

  2. 1 Svobodová J.

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Review of surfactin chemical properties and the potential biomedical applications

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Seydlová G., Svobodová J.
Open Medicine
|
2008
|
vol. 3
|
issue 2
123-133
EN
Surfactin, a highly powerful biosurfactant produced by various strains of the genus Bacillus, exhibits antibacterial, antiviral, antitumor and hemolytic action. This anionic cyclic lipopeptide is constituted by a heptapeptide interlinked with a β-hydroxy fatty acid. Due to its amhipathic nature surfactin incorporates into the phospholipid bilayer and induces permeabilization and perturbation of target cells. The rising antibiotic resistance as well as a number of remarkable surfactin activities shows that it deserves special interest and is considered as a candidate compound for combating several health related issues. In this review, the current state of knowledge of surfactin properties, biomedical potential and limitations for its application is presented.
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