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Activity of cancer procoagulant (CP) in serum of patients with cancer of lung, breast, oesophagus and colorectum

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Rucińska M., Furman M., Skrzydlewski Z., Zaremba E.
Acta Biochimica Polonica
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1997
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vol. 44
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issue 1
109-112
2
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Ocena jakości życia i aktywności seksualnej pacjentów po radykalnej radioterapii z powodu raka gruczołu krokowego w porównaniu z grupą zdrowych mężczyzn

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Rucińska M., Kieszkowska-Grudny A., Klimowicz K., Nawrocki S.
OncoReview
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2013
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vol. 3
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issue 1
18-24
EN
Background: Prostate cancer is a disease with a significant impact on quality of life (QoL) both during and after cancer treatment. The aim of study: The aim of this study was assessment of QoL and sexual activity of prostate cancer survivors after radiotherapy in comparison with the healthy men. Material and methods: 100 men were included to the study: 50 non-metastatic prostate cancer patients (54–83 years, median 69 years) after radical radiotherapy treatment (8–71 months; mean 27.5 months) and 50 healthy men (55–84 years, median 69 years). Subjects filled out a questionnaires that included EORTC QLQ.C-30 (version 3.0.), EORTC PR-25 and additional demographic and medical questionnaires. Results: Three and more months after prostate cancer treatment patients estimated their QoL on the same level as healthy subjects. The symptoms from genitourinary and gastrointestinal tracts did not impact on QoL. There were no significant differences in physical functioning, role functioning, emotional functioning, as well as in cognitive and social functioning. There were differences between too groups in sexual activity, erection and sexual satisfaction. Conclusions: Radical radiotherapy of prostate cancer patients does not impact on QoL and general health status. Some differences were observed in sexual activity, but it could also depend on additional hormonal treatment.
PL
Wstęp: Radykalna radioterapia raka gruczołu krokowego może mieć wpływ na jakość życia pacjentów zarówno w trakcie leczenia, jak i po jego zakończeniu. Cel pracy: Celem pracy było porównanie pod względem oceny jakości życia i satysfakcji seksualnej grupy mężczyzn po radykalnej radioterapii z powodu raka gruczołu krokowego z grupą mężczyzn niechorujących na raka. Materiał i metody: Badaniem objęto 100 losowo wybranych mężczyzn mieszkających w województwie warmińsko-mazurskim: 50 mężczyzn (54–83 lata; mediana 69 lat) z potwierdzonym histopatologicznie rozpoznaniem raka gruczołu krokowego, bez przerzutów odległych, po radykalnej radioterapii (8–71 miesięcy, średnio 27,5 miesiąca) i 50 mężczyzn (55–84 lata; mediana 69 lat), którzy nie mieli rozpoznanego raka gruczołu krokowego. Wykorzystano standaryzowane kwestionariusze EORTC QLQ.C-30 (wersja 3.0.), EORTC PR-25 oraz samodzielnie opracowaną ankietę. Wyniki: Nie wykazano statystycznie istotnej różnicy subiektywnej oceny ogólnej jakości życia między pacjentami po radykalnej radioterapii z powodu raka gruczołu krokowego a mężczyznami niechorującymi na raka. Nie stwierdzono obniżenia jakości życia spowodowanego zaburzeniami ze strony układów pokarmowego i moczowego. Nie wykazano istotnych różnic w funkcjonowaniu fizycznym, funkcjonowaniu w roli, funkcjonowaniu emocjonalnym, poznawczym i społecznym. Zaobserwowano zaś istotną różnicę między grupą badaną a kontrolną w aktywności seksualnej, uzyskaniu i utrzymaniu erekcji oraz zadowoleniu z seksu. Wnioski: Radykalna radioterapia z powodu raka gruczołu krokowego nie wpływa na ogólną jakość życia i generalne poczucie zdrowia w porównaniu z grupą kontrolną. Istotne różnice występują w sferze seksualnej, co może być związane również ze stosowaną u większości pacjentów hormonoterapią.
3
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Cardiooncological balance in a 75-year-old male with a hepatocellular carcinoma CS IV and a congestive heart failure NYHA III „de novo”

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Żechowicz M., Wroński K., Rucińska M.
OncoReview
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2015
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vol. 5
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issue 2
A57-61
EN
The case reports about a 75-years-old man without a previous medical history, in whom a heart failure NYHA III de novo was diagnosed together with persistent atrial fibrillation and hepatocellular carcinoma in clinical stage IV. Based on echocardiography and computed tomography there were pulmonary hypertension in course of lymphangiosis carcinomatosa as well as diffuse metastases in the abdomen diagnosed. Before the treatment initiation the patient was classified 3 in WHO performance status. After an improvement in control of the rhythm frequency and the heart failure treatment stabilisation with a β-blocker, an ACE-inhibitor, spironolactone and furosemide, the patient’s performance status improved to WHO 2. He was further disqualified from surgical procedures due to the advanced clinical stage of the oncological disease. Considering high probability of further cardiotoxic influence of sorafenib on the heart failure despite its satisfactory control, the patient was assigned to palliative chemotherapy with FOLFOX. Parallel he was strictly followed up cardiologically in an outpatient clinic what certainly supported the oncological treatment. The patient survived 32 weeks from the first hospitalization and the progression free survival was 12 weeks from the chemotherapy initiation.
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Acinetobacter Baumannii Nosocomial Infections

88%
Sieniawski K., Kaczka K., Rucińska M., Gagis L., Pomorski L.
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vol. 85
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issue 9
483-490
EN
Nosocomial infections caused by strains Acinetobacter baumannii strands are a growing clinical problem. The occurrence of multidrug-resistant strands is observed and that limits the ways of therapy considerably. The aim of the study was to determine the rate of infection and susceptibility spectrum of the species Acinetobacter baumannii isolated from patients treated at Maria Skłodowska-Curie Memorial Hospital in Zgierz with particular emphasis on surgical wards. Materials and methods. The material consisted of Acinetobacter baumannii isolates were obtained from samples of materials from patients treated at Maria Skłodowska-Curie Memorial Hospital in Zgierz from January to December 2011. Isolated bacterial strains were cultured at microbiological substrates. Isolates were identified to species using the VITEK 2 GN card (bioMérieux) and Vitek 2 automated system (bioMérieux). Susceptibility towards antibiotics of particular strains was determined by the means of AST NO 93 card. In the case of resistance towards carbapenem, the MIC was marked by E-test with Mueller Hinton substrate. The occurrence of MBL was verified by the means of disc system with Mueller Hinton substrate. Results. We have shown that total number of Acinetobacter baumannii infections at hospital was 140 (10,31% of total results of cultures). Percentage of Acinetobacter baumannii infections at wards: Intensive Care Unit 48%, Surgical Departments 20%, Internal Diseases Department 16%, Neurology 13%, other wards - 3%. The susceptibility percentage of Acinetobacter Baumannii against antibiotics: colistin 90%, imipenem 64%, meropenem 43%, ampicillin-sulbactam 28%, amikacin 27%, gentamicin 24%, cefepime 9%, ceftazidime 7%, ciprofloxacin 7% Conclusions. Acinetobacter baumannii infections are a significant proportion of nosocomial infections. Most relate to surgical wards and ICUs. Acinetobacter baumannii is resistant against most antibiotics. The highest percentage of sensitivity demonstrated for colistin and carbapenems
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Time to treatment of prostate cancer patients

76%
Rucińska M., Osowiecka K., Gałka S., Środa R., Wojciechowski P., Sugajska A.
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vol. 8
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issue 3
86-93
EN
Prostate cancer is one of the most common cancers in men. The incidence of prostate cancer increases systematically. The correlation between waiting time for oncological treatment and survival prognosis in prostate cancer is not clearly determined. The aim of the study was to estimate the waiting time from suspicion until prostate cancer diagnosis and treatment in Warmia and Mazury Voivodeship. Ninety-six consecutive prostate cancer patients treated with radical radiotherapy between November 2016 and June 2017 in the Department of Radiation Oncology of the Hospital of the Ministry of Internal Affairs with Warmia and Mazury Oncology Center in Olsztyn were included in the analysis. A questionnaire prepared especially for this study, and individual interviews with patients were used in the study. The obtained data was supplemented with medical records and hospital databases. In the case of twenty-nine men, the PSA concentration was measured due to urinary disorders, and the median time from symptoms until the first PSA test in that group was 168 days. The median time from PSA concentration > 4 ng/ml to biopsy of prostate cancer and start of treatment for all patients was 62 and 156 days, respectively. Hormone therapy was administered the quickest. A positive correlation was observed between the waiting time from histopathological confirmation of prostate cancer until treatment, and the distance from one’s place of residence to the oncological center (p < 0.05).
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