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Synthesis, spectral studies and antimicrobial activity of newly chalcones and isoxazoles in diphenyl amine derivatives

100%
Bhoraniya N. C., Purohit D. M.
World News of Natural Sciences
|
2024
|
vol. 54
17-25
EN
A new series of compounds, namely 2-{[4'-(3''-aryl)-2''-propene-1''-one-phenyl]amino}benzoic acids (3a-3j) and 2-{[4'-(5''-aryl)isoxazol-3''-yl]phenyl amino} benzoic acids (4a-4j), were synthesized. The structures of these compounds were confirmed by 1H NMR, IR, Mass spectral analysis. The compounds (3a-3j) and (4a-4j) have been evaluated their antimicrobial activity.
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Synthesis, spectral study and antimicrobial activity of some new 2-n-butyl-4-chloro-5-formyl imidazole (BCFI) analogues

71%
Pankhaniya P., Savaniya N. P., Bhoraniya N. C., Patel H. K., Purohit D. M.
World News of Natural Sciences
|
2024
|
vol. 55
69-78
EN
New chalcone derivatives (7a-7j) and thiosemicarbazone derivatives (9a-9j) containing 2-n-Butyl-4-chloro-5-formyl imidazole nucleus have been synthesized and their chemical structure were evaluated using Infrared spectroscopy (IR), Ultra-violet spectroscopy (UV-Vis.), 1H-NMR spectroscopy and mass spectroscopy. All the synthesized compounds were evaluated for their anti-bacterial activities against Gram-positive bacteria Bacillus subtilis & Staphylococcus epidermidis and gram-negative bacterial strain Pseudomonas aeruginosa & Porteous vulgaris. The anti-fungal activity was evaluated against Aspergillus niger. The activity of the compounds were compared with known standards such as streptomycin and nystatin. Among the synthesized chalcone derivatives 7d, 7g & 7h are potentially active against bacterial strains & fungi. Among the thiosemicarbazone derivatives 9a, 9g, 9j & 9i are moderately active against bacterial strains. While 9d & 9j shows good anti-fungal activity.
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