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DFT study on electronic structures and optical absorption properties of C, S cation- doped SrTiO3

100%

Liu J., Wang L., Liu J., Wang T., Qu W., Li Z.

Open Physics

2009

vol. 7

issue 4

762-767

The effects of C cation and S cation doping on the electronic structures and optical properties of SrTiO3 are investigated by density function theory (DFT) calculations. The calculated results reveal that the top of the valence band is predominately made up of the O 2p states for the pure SrTiO3. When SrTiO3 was doped with C cation and S cation, the top of the valence bands consists mainly of O 2p+C 2s hybrid orbitals and O 2p+S 3s hybrid orbitals, respectively. The band gap of SrTiO3 is narrowed by the doping with C cation and S cation, especially for the C and S-codoped SrTiO3. Moreover, the red shifts of the absorption edge are found by the calculated optical properties, which is consistent with reported experiment results. It is the explanation for their visible light respondency by the presence of C 2s and S 3s states on the upper edge of the valence band. All of these results can explain the good photocatalytic properties of C, S cation-codoped SrTiO3 under visible light irradiation.

Vps41, a protein involved in lysosomal trafficking, interacts with caspase-8

84%

Wang L., Pan X., He L., Zhang R., Chen W., Zhang J., Lu M., Hua Z.-C.

2013

vol. 60

issue 1

37-42

Caspase-8 is a member of the cysteine-aspartic acid protease (caspase) family which plays a central role in apoptosis and development. We screened caspase-8 interacting proteins from mouse T-cell lymphoma and 7.5-day embryo cDNA libraries by yeast two-hybrid system and obtained eleven positive clones, including Vacuolar protein sorting 41 (Vps41), a protein involved in trafficking of proteins from the late Golgi to the vacuole. The interaction of Vps41 with caspase-8 was confirmed by co-immunoprecipitation (co-IP) and co-localization studies in HEK293T cells. Co-IP experiments also showed that Vps41 binds to the p18 subunit of caspase-8 through its WD40 region and RING-finger motif. Furthermore, we found that overexpression of Vps41 promotes Fas-induced apoptosis in A549 human lung adenocarcinoma cells. The cleavage of caspase-3, a caspase-8 downstream effector, was increased when cells were transfected with Vps41-overexpressing plasmid. Together, these results suggest a novel interaction of caspase-8 with Vps41 and provide a potential role of Vps41 beyond lysosomal trafficking.

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1 Acta Biochimica Polonica

1 Open Physics

1 2013

1 2009

2 Wang L.

1 Chen W.

1 He L.

1 Hua Z.-C.

1 Li Z.

1 Liu J.

1 Lu M.

1 Pan X.

1 Qu W.

1 Wang T.

1 Zhang J.

1 Zhang R.

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DFT study on electronic structures and optical absorption properties of C, S cation- doped SrTiO3

Vps41, a protein involved in lysosomal trafficking, interacts with caspase-8