Search results

Sort By:

Limit search:

Ciało obce w woreczku łzowym – opis przypadku

100%

Wolnik A., Woś M., Woś J.

OphthaTherapy

2018

vol. 5

issue 4

241-244

A 78-year-old woman was admitted to the ophthalmology department for removal of a soft, painless raised lesion in the region of her left lacrimal sac. The lesion had been observed for several months. MRI images showed a cyst connected to the lacrimal sac. The patient's medical history revealed she had suffered from excessive tearing for 3 years and recurrent dacryocystitis. During the procedure of cyst removal, after tissue preparation the lesion appeared as an inflamed lacrimal sac with the old stenting material inside.

78-letnia kobieta została przyjęta na oddział okulistyki w celu usunięcia niebolesnej uniesionej zmiany w okolicy woreczka łzowego lewego, obecnej od kilku miesięcy. W rezonansie magnetycznym zmianę tę opisano jako torbiel pozostającą w łączności z woreczkiem łzowym. W wywiadzie kobieta skarżyła się na łzawienie lewostronne utrzymujące się od ok. 3 lat oraz epizody zapalenia woreczka łzowego lewego. Podawała także, że miała nacinany ropień woreczka łzowego lewego (w innym ośrodku). W trakcie zabiegu usunięcia torbieli zmiana ta okazała się zmienionym zapalnie woreczkiem łzowym, w którym znajdował się stary sączek.

Ocena ekspresji Foxp3 i RORgamma t w jednojądrzastych komórkach krwi obwodowej u chorych z rakiem krtani jako wskaźników zaawansowania zmian nowotworowych - badania wstępne

76%

Papież P., Bryś M., Lewy-Trenda I., Stasikowska O., Woś J., Papierz W., Starska K.

Polish Journal of Otolaryngology

2011

vol. 65

issue 5

109-116

The degree of activation of cells involved in cellular immune re-sponse against tumor antigens (cytotoxic lymphocytes Te) as well as efficiency of the mechanisms which promote immunosuppression (Treg - regulatory cells CD4±CD25±Foxp3±) may determine the course of the neoplastic disease. The aim of this study was to assess the function of autologous peripheral blood mononuclear cells (PBMCs) involved in the immunological processes on the basis of expression of Foxp3 and RORgamma t molecules as well as analysis of the relationships with clinical and morphological features of the tumor (pT and pN stage, G feature, degree of invasiveness according to the TFG classification) in laryngeal carcinoma. Materia! and methods: The analysis included a group of 59 patients with verified squamous celt carcinoma of the larynx. In the pathologic evaluation pTNM classification criteria, depth of invasion and degree of histological dif-ferentiation were used. Expression levels of mRNA for Foxp3 and RORgamma t in peripheral blood mononuclear cells by quantitative analysis of the amplified product in real time (real-time RT2-PCR) were evaluated. The level of Foxp3 and RORgamma t protein expression by Western blot analysis was determined. Results: In squamous celt carcinomas of the larynx, with the highest tumor aggressiveness the significantly highest level of mRNA and protein expres-sion for Foxp3 molecule were observed. The severity of Foxp3 expression at both gene and protein level were positively linearly correlated with the degree of local extent of the tumor (pT3-4), depth of invasion (invasion of cartilage) and the degree of histological differentiation (low-differentiated tumors G3). In the study group of laryngeal cancers significantly lower level of RORgamma t expression in carcinomas with less invasive changes (pT1-2, high-differentiated tumors G1, carcinomas with microinvasion without evi-dence of invasion beyond the lamina propria) was also noted. Conclusions: The study results indicate the important role of immune celt activity as indicators of advancement of clinical and morphological changes in squamous celt carcinoma of the larynx.

Refine search results

1 OphthaTherapy

1 Polish Journal of Otolaryngology

1 2018

1 2011

2 Woś J.

1 Bryś M.

1 Lewy-Trenda I.

1 Papierz W.

1 Papież P.

1 Starska K.

1 Stasikowska O.

1 Wolnik A.

1 Woś M.

Search results

Ciało obce w woreczku łzowym – opis przypadku

Ocena ekspresji Foxp3 i RORgamma t w jednojądrzastych komórkach krwi obwodowej u chorych z rakiem krtani jako wskaźników zaawansowania zmian nowotworowych - badania wstępne