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1

Adaptative mechanisms of the cell against oxidative stress and damage removal

100%
Farbiszewski R., Skrzydlewska E.
Postępy Higieny i Medycyny Doświadczalnej
|
1996
|
vol. 50
|
issue 6
613-620
EN
This review describe the role of adaptative mechanisms of the cell against oxidative damage induced by free radicals. Adaptative response refers the ability of cells to better resist the damaging effects of toxic agent when first preexposed to a lover dose. Extensive studies have revealed that oxidized proteins are recognized by proteases and completely degraded to amino acids. In this way damaged proteins are removed.
2

Interactions of free radicals with proteins

100%
Skrzydlewska E., Farbiszewski R.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
|
vol. 49
|
issue 6
7347-766
EN
This review describe the generation of free radicals in the cells under the influence of exogenously and endogenously acting factors.The interactions of free radicals with proteins and amino acids and the consequences of these effects are also presented.
3

The effect of protein oxidative modification on the protease-antiprotease balance and intracellular proteolysis

81%
Skrzydlewska E., Farbiszewski R., Gacko M.
Postępy Higieny i Medycyny Doświadczalnej
|
1997
|
vol. 51
|
issue 4
443-456
EN
This review describe the oxidative modification of proteins and its effect on the proteases and antiproteases activity. The changes in the proteolytic- -antyproteolytic balance and the susceptibility of the protein substrates on proteolysis are also presented.
4

The oxidative modification of protein during aging

81%
Augustyniak A., Ostrowska J., Skrzydlewska E.
Postępy Higieny i Medycyny Doświadczalnej
|
2001
|
vol. 55
|
issue 1
53-69
EN
In this review the influence of reactive oxygen species or other reactive substances on the different protein modifications during aging is described. The accumulation of such proteins is observed and many phenomena of aging and age-dependent diseases are due to this accumulation.
5

Changes in the intracellular protein degradation during aging

81%
Skrzydlewska E., Sulkowska M., Makiela M.
|
EN
This review describe the influence of free radicals on the protein degradation during aging. The consequences of aging are changes in susceptibility of proteins on the proteases action as well as changes in cell proteolytic systems activity in different organs.
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