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Regional strategies for pro-family policy in the care of rural child

100%
Sygit K., Stępień-Słodkowska M., Krajewska-Pędzik A., Kaczmarczyk M., Pielichowska E.
Central European Journal of Sport Sciences and Medicine
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2014
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vol. 7
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issue 3
73-80
EN
Health care of children and young people is part of a system of care of the so called “developmental age population.” In this system, prevention plays a key role. The aim of the study was, basing on the obtained results, to develop guidelines for the regional pro-family policy in care of a rural child. The study included children and young people of school age, from 14 to 19 years of age. Overall the analysis included 6,971 children and adolescents and 6,971 parents. Organization of health care of children and school adolescents depended on the solutions approved by individual founding bodies of Health Care Units and Regional Patients’ Funds. The withdrawal of nurses from school was observed. The tasks of prevention character performed previously by nurses employed at schools began to be implemented within the framework of primary health care in the child’s place of residence. For proper implementation of the tasks of school nurses and the proper development of school hygiene, it is important to establish a uniform and maximum number of pupils per one nurse, taking into account all circumstances, and to develop standards of care for the student, taking into account the age of the student, school type, and the region.
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Interaction Between ACE I/D and ACTN3 R557X Polymorphisms in Polish Competitive Swimmers

86%
Grenda A., Leońska-Duniec A., Kaczmarczyk M., Ficek K., Król P., Cięszczyk P., Żmijewski P.
Journal of Human Kinetics
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2014
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vol. 42
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issue 1
127-136
EN
We hypothesized that the ACE ID / ACTN3 R577X genotype combination was associated with sprint and endurance performance. Therefore, the purpose of the present study was to determine the interaction between both ACE ID and ACTN3 R577X polymorphisms and sprint and endurance performance in swimmers. Genomic DNA was extracted from oral epithelial cells using GenElute Mammalian Genomic DNA Miniprep Kit (Sigma, Germany). All samples were genotyped using a real-time poly- merase chain reaction. The ACE I/D and the ACTN3 R577X genotype frequencies met Hardy-Weinberg expectations in both swimmers and controls. When the two swimmer groups, long distance swimmers (LDS) and short distance swimmers (SDS), were compared with control subjects in a single test, a significant association was found only for the ACE polymorphism, but not for ACTN3. Additionally, four ACE/ACTN3 combined genotypes (ID/RX, ID/XX, II/RX and II/XX) were statistically significant for the LDS versus Control comparison, but none for the SDS versus Control comparison. The ACE I/D and the ACTN3 R577X polymorphisms did not show any association with sprint swimming, taken individually or in combination. In spite of numerous previous reports of associations with athletic status or sprint performance in other sports, the ACTN3 R577X polymorphism, in contrast to ACE I/D, was not significantly associated with elite swimming status when considered individually. However, the combined analysis of the two loci suggests that the co-occurrence of the ACE I and ACTN3 X alleles may be beneficial to swimmers who compete in long distance races
3
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Conjugated linoleic acids regulate triacylglycerol and cholesterol concentrations in macrophages/foam cells by the modulation of CD36 expression

73%
Stachowska E., Baskiewicz M., Marchlewicz M., Czupryńska K., Kaczmarczyk M., Wiszniewska B., Machaliński B., Chlubek D.
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2010
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vol. 57
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issue 3
379-384
EN
Atherosclerosis is an inflammatory disease characterised by the accumulation of lipids and their metabolites in the artery wall. During inflammation circulating LDL are taken up by macrophages through two major scavenger receptors: CD36 and scavenger receptor A (SRA). Fatty acids that are common in food, e.g. linoleic acid and n-3 unsaturated fatty acids can modulate expression of CD36 on the macrophage surface. Conjugated linoleic acid isomers (CLA) that originate from the human diet, have demonstrated antiatherogenic properties in several experiments. Animal study evidenced that CLA could induce resolution of plaque by activation of peroxisome proliferator activated receptors and down-regulation of pro-inflammatory genes. Less unequivocal results were obtained in human studies (on the CLA effects on the inflammatory process). Therefore in this study we investigated the influence of CLA on CD36 expression and lipid accumulation in human macrophages. Macrophages were incubated with 30 µM cis-9,trans-11 CLA, trans-10,cis-12 CLA or linoleic acid for 48 h. After that, expression of CD36 as well as accumulation of lipids were measured by flow cytometry, microscopy and a spectroscopic method. We demonstrate that both cis-9,trans-11 C 18:2 CLA and linoleic acid slightly elevated expression of CD36, whereas second isomer - trans-10,cis-12 CLA - did not. Nevertheless, only trans-10,cis-12 CLA triggered delipidation of macrophages, that is decreased triacylglycerols concentration. Also in human adipocytes, trans-10,cis-12 CLA causes cell delipidation by reduction of PPAR receptor expression. We propose a similar mechanism for human macrophages/foam cells.
4
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The Variants Within the COL5A1 Gene are Associated with Reduced Risk of Anterior Cruciate Ligament Injury in Skiers

59%
Stępień-Słodkowska M., Ficek K., Kaczmarczyk M., Maciejewska-Karłowska A., Sawczuk M., Leońska-Duniec A., Stępiński M., Ziętek P., Król P., Chudecka M., Cięszczyk P.
Journal of Human Kinetics
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2015
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vol. 45
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issue 1
103-111
EN
The purpose of this study was to examine the association of the BstUI RFLP C/T (rs 12722) and DpnII RFLP C/T (rs 13946) COL5A1 polymorphisms, individually and as haplotypes, with anterior cruciate ligament ruptures in recreational skiers. Subjects were 138 male recreational skiers with surgically diagnosed primary anterior cruciate ligament ruptures. The control group consisted of 183 apparently healthy male recreational skiers, who were without any self-reported history of ligament or tendon injury. DNA was extracted from buccal cells donated by the subjects and genotyping was carried out using real-time PCR. The genotype distributions for both polymorphisms met Hardy- Weinberg expectations in both groups. There were no significant differences in genotype distribution of allele frequencies of COL5A1 BstUI RFLP C/T and COL5A1 DpnII RFLP C/T polymorphisms between the ACL rupture and control groups. The T-T (BstUI RFLP T, DpnII RFLP T) haplotype was the most common (55.6%). The haplotype T-C was not present in any of the subjects. There was an underrepresentation tendency of the C-T haplotype in the study group compared to controls under recessive mode of inheritance. Higher frequency of the COL5A1 BstUI RFLP C/T and COL5A1DpnII RFLP C/T polymorphisms haplotype is associated with reduced risk of anterior cruciate ligament injury in a group of apparently healthy male recreational skiers.
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