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Mechanism of Action of Chaperones in Protein Function

100%
Adio W. S., Obunadike C. V., Ogunsanmi A. O.
World News of Natural Sciences
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2022
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vol. 44
333-354
EN
The building blocks of living cells, proteins are enormous collections of nitrogenous organic molecules that are polymers of the amino acids that animals must consume to grow and repair their tissues. ATP-dependent proteins known as chaperones serve as foldases (protein folding assistants), holdases (bind folding intermediates), and disaggregates (convert aberrant protein to monomers). Chaperones include, but are not limited to, DnaJ, DnaK, GrpE, and Hsp33. The majority of chaperones have a cleft containing the nucleotide-binding site that divides the ATPase domain into two subdomains. The features of the C-terminal domain depend on the kind of bound nucleotide. In the presence of ATP, peptides bind and dissociate quickly and with low affinity. In contrast, the affinity increases significantly while the rate of peptide binding reduces when neither ADP nor nucleotide are connected to the N-terminal domain. Hsp90 is a homodimer with a 60 n dissociation constant. In reaction to high temperature or other types of cellular stress that prevent protein folding, several chaperones turn on their activity. Neurodegenerative, Parkinson's, and polyQ diseases, among others, can all be treated with chaperones. This is possible when a protein prevents the accumulation of protein species with improper folding. The suppression of dangerous protein oligomers by clustering, illness response related to protein aggregation, and cancer maintenance are a few new functions for chaperones that are still being discovered.
2
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A review on drug-diet interaction

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Adio W. S., Ogunwole A. C., Mary F. I.
World News of Natural Sciences
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2022
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vol. 43
108-125
EN
Food-drug interactions can have a significant impact on the efficacy of pharmacological treatment and the adverse effect profiles of many treatments. Interactions are not necessarily harmful to therapy, but they can be employed to promote drug absorption or reduce side effects in some circumstances. Drug interactions with grapefruit juice, in particular, have gotten a lot of attention recently. As new drugs are approved at a faster rate, there is less information accessible concerning their side effects and interactions once they hit the market. The use of herbal medicines and dietary supplements is a second source of worry. These items are not subjected to rigorous testing and may contain little or no of the ingredient listed on the label. Some of the herbs utilized have the potential to interact negatively with prescription medications. Mahuang (ephedra) and fever few are two noteworthy examples. Mahuang is a stimulant that can lead to hypertension in those who are on monoamine oxidase inhibitors. Fever fever has anticoagulant qualities that can help warfarin work better. The majority of food-drug interactions occur due to one of three mechanisms: decreased absorption rate or extent, enhanced absorption rate or extent, or chemical/pharmacologic effects. Acid-labile medicines, such as penicillin G, ampicillin, and dicloxacillin, are destroyed when there is an increase in stomach acid. In other circumstances, dietary components like calcium or iron may create compounds with the medicine that make it harder to absorb. Tetracycline, sodium fluoride, and ciprofloxacin are some examples. Food, calcium, and practically everything, including orange juice and coffee, interfere with lendronate absorption. The exact process through which food interferes with absorption is unknown in many circumstances. The area under the curve (AUC) may be comparable regardless of how the drug is administered; delayed absorption does not always diminish total overall exposure to the drug.
3
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Current trends in the treatment of sickle cell anemia

100%
Adio W. S., Christopher F. C., Adesola R. O., Mary F. I.
World News of Natural Sciences
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2022
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vol. 43
60-75
EN
Sickle cell disease is a set of illnesses characterized by the misshaping and breakdown of red blood cells. Red blood cells twist into a sickle shape in sickle cell disease, an inherited set of illnesses. The cells die early, resulting in a lack of healthy red blood cells (sickle cell anemia), and they might impede blood flow, causing pain (sickle cell crisis). Vernon Mason coined the term "sickle cell anemia" in 1922. SCD is thought to have killed approximately 114,800 individuals worldwide, and it is more common among people whose ancestors lived in tropical and subtropical sub-Saharan Africa, where malaria is or was prevalent. There are several types of SCD, including homozygous HbS and HbS/HbC co-inheritance (usually called HbSC). A genetic mutation causes the condition, which disrupts the iron-rich molecule essential for making blood red and transporting oxygen. SCD has been treated using a variety of approaches. The use of hydroxycarbamide and L-glutamine, blood transfusions, bone marrow transplants, gene therapy, and nutritional supplementation are just a few of them. Gene therapy is the most effective treatment option on the list. The method relies on modifying and reprogramming cells from the patient's own blood cells, as well as genetic engineering, to fix the inborn genetic defect. hydroxyurea, on the other hand, has been shown to change the course of the disease. Finally, if utilized correctly, a combination of available therapeutic medications could greatly improve the disease.
4
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Effect of pesticide residue in food crops on man and his environment

64%
Obunadike C. V., Yakubu Y. Y., Abdulrazaq O. O., Ogunsanmi A. O., Muhammad Z., Adio W. S., Lawal I. A., Adisa A. S.
World News of Natural Sciences
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2022
|
vol. 44
192-214
EN
The use of pesticides has been a catalyst that improves crop quality and yield. It can be designed using conventional or modern technologies depending on the type of pesticides being used. It is used to prevent organisms that are considered to be harmful to crop growth and development by protecting them from pests and diseases, thus increasing food crop’s quality. There are several classifications of pesticides among which are; insecticides, fungicides, rodenticides, etc. Physicochemical and biological methods are the basic two ways of detecting pesticide poisoning. Immunoassays (biological) are the most prominent methods of detection, it requires the use of fluorescent, chemiluminescent or other detection methods to detect drugs, proteins, and some hormones. Pesticide residues are responsible for environmental pollution such as groundwater contamination, global warming and killing non-target organisms in the soil. Exposing the human body to excess pesticide residue can lead to various severe health conditions such as cancer, asthma, etc. The metabolism of pesticides in the body system undergoes two stages, namely; phase one and phase two. oxidation reactions occur in phrase one whereby pesticides functional groups are majorly synthesized by Cytochrome P450 enzymes. Phase two includes the reactions of phase I substrate with glucuronic acid (C6H10O7), tetraoxosulphate(VI) acid (H2SO4), ethanoic acid (CH3COOH), etc. to form more polar compounds for easy excretion. The introduction of inexpensive biodegradable pesticides and the enforcement and implementation of pesticide control and regulation laws has helped to decrease the negative effects of pesticide residue in humans and the surroundings. Pesticide residue can be eliminated or reduced from food crops by practicing organic farming, washing, and food product processing, natural pesticide application, and rational use of pesticides. It is highly recommended to follow the prescription of pesticides used to avoid its toxicity in the biological systems.
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