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1

Bioencapsulation of biologically active compounds In matrices obtained by sol-gel metod and its application

100%

Polska K., Fiedurek J., Radzki S.

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2007

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issue 1

77-95

EN

The encapsulation of biomolecules, e.g. enzymes, whole living cells or microorganisms in sol-gel derived monolithic silica, has been widely studied in recent years. Upon encapsulation, biomolecules retain their spectroscopic properties and biological activity. Sol-gel matrices are thermally and chemically stable and can be obtained in a variety of forms, such as optically transparent monoliths, granulates, microparticles or thin films. Sol-gel immobilization is characterized by physical entrapment without chemical modification. Immobilizing substances by physically trapping in individual pore of a matrix permits their molecules to be isolated and stabilized. The advantages of sol-gel encapsulated biologicals might give them applications such as optical and electrochemical sensors, diagnostic devices, catalysts, and even bioartificial organs. While the relatively large biomolecules are immobilized within the silica network, small ions or molecules are transported into the interior of the matrix.

2

Porphyrins and phthalocyanines. Part I. Properties and some applications

88%

Trytek M., Makarska M., Polska K., Radzki S., Fiedurek J.

Biotechnologia

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2005

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issue 4

109-127

EN

Nowadays, the chemistry of porphyrins, phthalocyanines and related compounds (usually named as tetrapyrrolic rings) is one of the most interesting and promising subjects of supramolecular chemistry, because of unique photoactive properties of the porphyrin rings and their ability of electron transfer. The possibility of synthesis of tetrapyrroles with countless organic groups substituted to nine reactive centers of porphyrin ring and synthesis of complexes with almost all metal ions and, additionally, easy to modify the molecular structure of such obtained compounds give a chance of using the porphyrins in many different areas of life. In this paper, we present the most significant problems concerning porphyrins and their metal complexes, such as the molecular structures and physicochemical properties. We also show the most interesting applications, including the role of porphyrins as photosensitizers in photolysis of water and in photodynamic therapy (PDT).

3

Porphyrins and phthalocyanines. Part. II. Porphyrins as biomimetic catalysts in organic compounds transformation

88%

Trytek M., Fiedurek J., Polska K., Makarska M., Radzki S.

Biotechnologia

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2005

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issue 4

128-141

EN

The interest in the use of metal porphyrins in biomimetic catalysis has been constantly increasing during the last twenty years, as the enzymology studies were showing the role of this complexes as prosthetic groups of cytochromes P-450, peroxidases and catalases. In particular, a number of research groups have focused their interest on the ability of metal porphyrins to catalyze redox processes on organic compounds under mild conditions, both for converting these compounds into more usuful products and for purifying industrial effluents. The aim of this review is to highlight the efforts of researchers in utilising metalloporphyrins for economically attractive processes. Interesting reactions are allylic hydroxylations of cheap and readily available precursor monoterpenes (like limonene, pinene) for potential production of valuable natural flavour and fragrance compounds, selective oxidation of alkyl chains of the alkanes, regioselective oxidation of cyclic hydrocarbons (eg. cycloheksan), steroids, as well as reduction of the halogenated alkanes.

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3 Biotechnologia

1 2007

2 2005

3 Fiedurek J.

3 Polska K.

3 Radzki S.

2 Makarska M.

2 Trytek M.

Bioencapsulation of biologically active compounds In matrices obtained by sol-gel metod and its application

Porphyrins and phthalocyanines. Part I. Properties and some applications

Porphyrins and phthalocyanines. Part. II. Porphyrins as biomimetic catalysts in organic compounds transformation