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1

Allergic inflammation - the role of adhesion process

100%
Pawliczak R., Kowalski M. L.
Postępy Higieny i Medycyny Doświadczalnej
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1997
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vol. 51
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issue 1
39-54
EN
Adhesion molecules (AMs) are one of the main research areas in biology, cytology and medicine. During last years a great number of AMs was discovered and employed in several mechanisms, including inflammation. Bronchial asthma, allergic rhinitis and conjunctivitis are considered as inflammatory disorders. Based on both in vitro and in vivo studies several mechanisms of selective recruitment eosinophils and basophils through AMs have been developed. Moreover, cytocines, biological peptides and other mediators play role in expression and function of adhesion molecules. Although several aspects of these processes still remains unclear, in vivo data (from animal and human experiments) document the existing of some of these mechanisms. Additional studies, including the use of adhesion molecule antagonists, will clarify the importance of leukocyte adhesion in the pathophysiology of allergic diseases. This review article describes characteristics, properties, regulation of expression and the role of leukocyte- -endothelial adhesion molecules in pathogenesis of allergic diseases.
2

A genom ? wide range analysis of gene expression ? application in biological sciences and medicine

100%
Pawliczak R., Kowalski M. L.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
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vol. 56
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issue 4
537-553
EN
Microarrays are one of the latest breakthroughs in experimental molecular biology, which allow monitoring of gene expression for tens of thousands of genes in parallel and are already producing huge amounts of valuable data. Microarray RNA expression on a genome-wide range is now a proven technology, although the idea of analysis of expression many genes in one sample is not new. Since the development of clone printing technology and oligonucleotide synthesis allowed to produce high density microarray. In this publication we provide the information about the technology, available detection systems and data analysis software. Comprehensive review of current or fundamental papers using microarray technology application in immunology, rheumatoid arthritis, oncology, cystis fibrosis research, primary pulmonary hypertension, psychiatry, and allergic airways inflammation is also included.
3

Leukotrienes ? mediators of inflammation

81%
Woszczek G., Pawliczak R., Kowalski M. L.
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EN
Leukotrienes are biologically active metabolites derived from arachidonic acid playing an important role in inflammatory responses. There are two main groups of leukotrienes: dihydroxy-leukotrienes (LTB4) and cysteinyl-leukotrienes (LTC4, LTD4, LTE4). By activating specific G-protein coupled receptors, leukotrienes take part in immune responses, like activation and chemotaxis of leukocytes. Several studies have shown that leukotrienes may play a significant role in pathomechanisms of inflammatory diseases of human airways, skin, digestive tract and heart.
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