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Asymetria mózgu jako objaw radiologiczny pomocny w dalszej diagnostyce neurologicznej - przegląd kliniczno-radiologiczny wybranych jednostek neurologicznych związanych z asymetrią budowy mózgu

100%
Jączak-Goździak M., Stajgis M., Steinborn B.
Neurologia Dziecięca
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2020
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vol. 29
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issue 58
33-44
EN
The asymmetry of the cerebral hemispheres is a physiological phenomenon and the dominance of one of the sides, especially the functional one, is particularly clear in the sphere of cognitive functions. In contrast to the physiological, the pathological inequality of the cerebral hemispheres shows significant differences in the anatomical and histological structure and there are symptoms such as paresis, epileptic seizures, cognitive disorders and movement disorders. The article presents selected syndromes related to the asymmetry of the cerebral hemispheres, classifies them according to their etiology and course (into progressive and non-progressive), and presents their clinical and radiological characteristics.
PL
Asymetria półkul mózgu jest zjawiskiem fizjologicznym, a dominacja jednej ze stron, zwłaszcza czynnościowa, jest szczególnie wyraźna w sferze funkcji poznawczych. W odróżnieniu do fizjologicznej, w patologicznej nierówności półkul mózgowych występują znaczne różnice w budowie anatomicznej i histologicznej oraz pojawiają się objawy takie jak niedowłady, napady padaczkowe, zaburzenia funkcji poznawczych czy zaburzenia ruchowe. W artykule przedstawiono wybrane zespoły powiązane z asymetrią półkul mózgu, dokonano klasyfikacji ze względu na etiologię oraz przebieg (na postępujące i niepostępujące), przedstawiono ich kliniczną oraz radiologiczną charakterystykę.
2
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Association between estrogen receptor alpha gene polymorphisms and bone mineral density in Polish female patients with Graves' disease

76%
Ignaszak-Szczepaniak M., Horst-Sikorska W., Dytfeld J., Gowin E., Słomski R., Stajgis M.
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2011
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vol. 58
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issue 1
101-109
EN
Graves' (GD) hyperthyroidism leads to reduced bone mineral density (BMD) accompanied by accelerated bone turnover. Ample studies have identified association between estrogen receptor (ESR1) gene polymorphism and decreased BMD and osteoporosis. In contrast, number of publications that link ESR1, BMD and Graves' disease is limited. The purpose of this study was to identify the association between ESR1 polymorphisms and BMD in premenopausal women with GD and to determine whether ESR1 polymorphic variants can predispose to GD. The study included 75 women aged 23-46 years with GD and 163 healthy controls. BMD was measured at lumbar spine and femoral neck. We investigated two SNPs in the ESR1 gene and analyzed genetic variants in the form of haplotypes reconstructed by statistical method. Three out of four possible haplotypes of the PvuII and XbaI restriction fragment length polymorphisms were found in GD patients: px (55.3 %), PX (33.3 %) and Px (11.4 %). Women homozygous for xx of XbaI and for pp of PvuII had the lowest BMD at lumbar spine. Moreover, the px haplotype predisposed to reduced lumbar BMD. No associations were observed for femoral neck BMD. No statistically significant relationship were found between ESR1 polymorphisms or their haplotypes and GD. These results indicate that the PvuII and the XbaI polymorphisms of ESR1 gene are associated with bone mineral density in premenopausal women with GD and may help to estimate the risk of bone loss particularly at lumbar spine. However, none of the ESR1 gene alleles predict the risk of GD in Polish female patients.
3
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Usefulness of Magnetic Resonance Imaging in Diagnosis and Monitoring of Treatment of Perianal Fistulas

76%
Katulska K., Wykrętowicz M., Stajgis P., Krokowicz Ł., Banasiewicz T., Stajgis M.
Polish Journal of Surgery
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2015
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vol. 86
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issue 8
383-390
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