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Magnetic Resonance Imaging Analysis of Moving Fronts in Floating Dosage Forms

100%

Kulinowski P., Dorożyński P., Jachowicz R., Jasiński A.

Acta Physica Polonica A

2005

vol. 108

issue 1

155-160

An application of magnetic resonance imaging in the field of pharmaceutical technology is presented in this paper. The analysis of diffusion and swelling fronts was carried out for four floating dosage forms using magnetic resonance imaging. The influence of polymer viscosity, its concentration, and type of applied dissolution media on the area of moving fronts was investigated.

2-Deoxyglucose induces beta-APP overexpression, tau hyperphosphorylation and expansion of the trans-part of the Golgi complex in rat cerebral cortex

52%

Grieb P., Gordon-Krajcer W., Frontczak-Baniewicz M., Walski M., Ryba M. S., Kryczka T., Fiedorowicz M., Kulinowski P., Sulek Z., Majcher K., Jasinski A.

Acta Neurobiologiae Experimentalis

2004

vol. 64

issue 4

491-502

The effects of a single intraperitoneal injection of a non-metabolizable glucose analog 2-deoxyglucose (2-DG, 500 mg/kg) on the levels of b-APP expression, and phosphorylated and unphosphorylated tau protein in the rat cerebral cortex were investigated. The effects of 2-DG on the ultrastructure of cortical neurons with particular emphasis on the morphology of the Golgi apparatus, and on brain bioenergetics assessed by in vivo 31P-MRS technique were also evaluated. Seven and a half hours after injection of 2-deoxyglucose a significant increase in brain cortex b-APP expression, increased tau phosphorylation, and a marked relative expansion of the trans- part of the Golgi intracellular secretory pathway in cortical neurons has been found. The changes of b-APP expression and tau phosphorylation appeared within 1 h after 2-DG application and continued for at least 24 h. However, brain 31P resonance spectra remained unchanged for up to 7.5 h after 2-DG. It is suggested that the increase of b-APP expression represents a response of brain tissues to 2-DG-evoked biochemical stress, while tau hyperphosphorylation and the change in Golgi morphology may be secondary phenomena.

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1 Acta Neurobiologiae Experimentalis

1 Acta Physica Polonica A

1 2005

1 2004

2 Kulinowski P.

1 Dorożyński P.

1 Fiedorowicz M.

1 Frontczak-Baniewicz M.

1 Gordon-Krajcer W.

1 Grieb P.

1 Jachowicz R.

1 Jasinski A.

1 Jasiński A.

1 Kryczka T.

1 Majcher K.

1 Ryba M. S.

1 Sulek Z.

1 Walski M.

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Magnetic Resonance Imaging Analysis of Moving Fronts in Floating Dosage Forms

2-Deoxyglucose induces beta-APP overexpression, tau hyperphosphorylation and expansion of the trans-part of the Golgi complex in rat cerebral cortex