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The acute effects of 3-nitropropionic acid on the behavior and spontaneous cortical electrical activity of rats

100%
Lukacs A., Szabo A., Vezer T., Papp A.
Acta Neurobiologiae Experimentalis
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2006
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vol. 66
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issue 3
227-234
EN
In this study, the acute effect of 3-nitropropionic acid was investigated on open field and startle behavior of rats, and on their cortical electrical activity. Spontaneous locomotor activity, acoustic startle response, and pre-pulse inhibition of acoustic startle were measured in male Wistar rats (10 weeks old, 180?200 g body weight) after a single dose of 10 or 20 mg/kg i.p. 3-nitropropionic acid. After the behavioral tests, the rats were anaesthetized, and spontaneous cortical electrical activity was recorded. The vertical, horizontal and local open field performance showed dose-dependent deterioration in the rats treated with 3-nitropropionic acid. The number of ?noise-positive' startle responses showed non-significant changes, but the inhibition by pre-pulse was significantly reduced in the high dose animals. High dose also increased the proportion of low-frequencies in the cortical activity. 3-nitropropionic acid, known primarily to act in repeated doses (e.g., in animal models of Huntington's disease) had also some clear-cut acute effects on behavioral and electrophysiological parameters of the treated rats.
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Production of Similar Fragments from the Glycine, Alanine, and Methionine Amino Acid Molecules under Low-Energy Electron Impact

76%
Romanova L., Tamuliene J., Vukstich V., Snegurskaya T., Papp A., Snegursky A.
Acta Physica Polonica A
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2015
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vol. 128
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issue 1
15-24
EN
Production of the ionic fragments of the same chemical composition due to a low-energy electron impact on the glycine, alanine, and methionine amino acid molecules has been studied both experimentally and theoretically. The mass-spectrometric technique was applied to detect the above ionic fragments within the 1-720 a.m.u. mass range with the ± 0.25 a.m.u. resolution, while the density functional theory based theoretical approach allowed the relevant species to be identified and the mechanisms of their production to be clarified. A special attention has been paid to analysis of the geometrical structures of the molecules under study as well to finding the appearance potentials of their fragments with the accuracy of ±0.1 eV.
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