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1
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Lipids and signal transduction in the nucleus.

100%
Dygas A., Barańska J.
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2001
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vol. 48
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issue 2
541-549
EN
During the last few years a growing amount of data has accumulated showing phospholipid participation in nuclear signal transduction. Very recent data strongly support the hypothesis that signal transduction in the nucleus is autonomic. Local production of inositol polyphosphates, beginning with the activation of phospholipase C is required for their specific function in the nucleus. Enzymes which modify polyphosphoinositols may control gene expression. Much less information is available about the role of other lipids in nuclear signal transduction. The aim of this minireview is to stress what is currently known about nuclear lipids with respect to nuclear signal transduction.
2
Content available remote

Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells.

100%
Czajkowski R., Barańska J.
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2002
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vol. 49
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issue 4
877-889
EN
In this review we summarize the present status of our knowledge on the enzymes involved in the extracellular metabolism of nucleotides and the receptors involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling pathways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on the P2Y2 receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y1 and P2Y12. The former is linked to phospholipase C and the latter is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP- and adenosine-induced pathways, leading to simultaneous regulation of inositol 1,4,5-trisphosphate and cAMP mediated signalling, is discussed.
3
Content available remote

Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells

100%
Wójcik M., Barańska J.
Acta Biochimica Polonica
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1999
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vol. 46
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issue 1
125-131
4
Content available remote

Życie i tragiczna śmierć Jakuba Karola Parnasa, wybitnego polskiego biochemika, współodkrywcy glikolizy

81%
Barańska J., Dżugaj A., Kwiatkowska-Korczak J.
Kosmos
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2008
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vol. 57
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issue 1-2
1-17
EN
The contribution of Jakub Karol Parnas (1884-1949), a prominent Polish scientist, to the understanding of muscle biochemistry, including ammonia and carbohydrates sources and nucleotide metabolism, is described. Among his main achievements was the discovery of glycogen phosphorolysis, the first use of radioactive phosphorus in biological studies, and formulation and proof of phosphate transfer between glycolytic intermediates and ATP. The rewarding and successful life led by this man of great scientific and intellectual abilities up to the beginning of the Second World War, his dramatic fate during the war, and his tragic death in a Soviet prison reflects the turbulent 20th history of the region.
5
Content available remote

Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells

81%
Dygas A., Sidorko M., Bobeszko M., Barańska J.
Acta Biochimica Polonica
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1999
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vol. 46
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issue 1
99-106
6
Content available remote

Store-operated calcium entry in physiology and pathology of mammalian cells

81%
Targos B., Barań0ska J., Pomorski P.
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2005
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vol. 52
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issue 2
397-409
EN
One of the numerous calcium-involving processes in mammalian cells is store-operated calcium entry (SOCE) - the process in which depletion of calcium stores in the endoplasmic reticulum (ER) induces calcium influx from the extracellular space. Previously supposed to function only in non-excitable cells, SOCE is now known to play a role also in such excitable cells as neurons, muscles and neuroendocrine cells and is found in many different cell types. SOCE participates not only in processes dependent on ER calcium level but also specifically regulates some important processes such as cAMP production, T lymphocyte activation or induction of long-term potentiation. Impairment of SOCE can be an element of numerous disorders such as acute pancreatitis, primary immunodeficiency and, since it can take part in apoptosis or cell cycle regulation, SOCE may also be partially responsible for such serious disorders as Alzheimer disease and many types of cancer. Even disturbances in the 'servant' role of maintaining ER calcium level may cause serious effects because they can lead to ER homeostasis disturbance, influencing gene expression, protein synthesis and processing, and the cell cycle.
7
Content available remote

Thapsigargin: potent inhibitor of Ca^2+ transport ATP-ases of endoplasmic and sarcoplasmic reticulum

81%
Sabała P., Czamy M., Woronczak J. P., Barańska J.
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vol. 40
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issue 3
309-319
8
Content available remote

Ca2+-dependent phosphatidylserine synthesis in immature and mature starfish oocytes.

81%
Dygas A., Barańska J., Santella L.
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2003
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vol. 50
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issue 2
377-387
EN
We found that in starfish oocytes two different enzymes, phosphatidylserine synthase-1 (PSS1) and -2 (PSS2), which synthesize phosphatidylserine by a base-exchange reaction, are present. We studied phosphatidylserine synthesis in immature oocytes which still contain the nucleus (germinal vesicles) and in mature cells, in which the re-initiation of the meiotic cycle induced by the hormone 1-methyladenine led to structural changes in the endoplasmic reticulum, to the disappearance of the nuclear envelope and to the intermixing of the nucleoplasm with the cytoplasm. It was found that the levels of PSS1 and PSS2 transcripts were higher in immature and mature oocytes, respectively. The level of the expressed PSS2 protein, higher than that of PSS1, was not influenced by the maturation process, whereas the level of PSS1 protein was higher in immature than in mature oocytes. Serine incorporation into phosphatidylserine was enhanced in immature oocytes. The depletion of calcium stores by thapsigargin resulted in 50% lowering of phosphatidylserine synthesis. We suggest that changes in phosphatidylserine synthesis may be affected by the release of calcium stored in the nuclear envelope and in the endoplasmic reticulum, the membranes that undergo disintegration and fragmentation during meiosis. The reason for the greater synthesis of PS may be the higher level of expression of PSS1 in immature oocytes.
9
Content available remote

ATP-dependent phosphatidylserine formation in animal cells as a base exchange

70%
Czarny M., Sabała P., Barańska J.
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vol. 40
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issue 3
301-308
10
Content available remote

Effect of Rho-associated kinase inhibition on actin cytoskeleton structure and calcium response in glioma C6 cells

61%
Targos B., Pomorski P., Krzemiński P., Barańska J., Rędowicz M. J., Kłopocka W.
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2006
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vol. 53
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issue 4
825-831
EN
The role of actin cytoskeleton functional state in glioma C6 cell morphology and calcium signaling was investigated through modification of myosin II activity by blocking Rho-associated kinase with the specific inhibitor Y-27632. Treatment of glioma C6 cells with ROCK inhibitor resulted in actin cytoskeleton reorganization and also in the changed shape and distribution of mitochondria. Changes in the distribution of ER, the main calcium store in glioma C6 cells, were not visible. The inhibition of myosin II activity influences the first phase of calcium signaling evoked by agonist, and both phases of thapsigargin-evoked calcium response. We suggest that the observed increase in Ca2+ release from intracellular stores induced by IP3 formation as well as inhibition of SERCA ATPase is at least in part related to severely affected mitochondria. Enhancement of capacitative calcium entry evoked by thapsigargin is probably associated with the reorganization of the acto-myosin II system. ATP-induced calcium response presents no changes in the second phase. We observed that ATP stimulation of Y-27632 pretreated cells leads to immediate morphological rearrangement of glioma C6 cells. It is a consequence of actin cytoskeleton reorganization: formation of stress fibers and relocation of phosphorylated myosin II to actin filaments. It seems that the agonist-evoked strong calcium signal may be sufficient for myosin II activation and the stress fiber organization. This is the first work showing the dependence between the functional state of the acto-myosin II system and calcium signaling stressing the reversible character of this relationship.
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