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Factors Associated with Physical Activity in People with Diabetes

100%

Sieńko-Awieraniów E., Stępień-Słodkowska M., Latkowska A., Głowacka E.

Central European Journal of Sport Sciences and Medicine

2015

vol. 12

issue 4

73-81

Background: Diabetes mellitus is a chronic disease related to the occurrence of numerous metabolic disorders. Their common feature is hyperglycaemia, caused by insufficient insulin secretion or its malfunction. The World Health Organization states that 346 million people worldwide have diabetes. The studies in adults with type 2 diabetes clearly demonstrate that the change of lifestyle behaviours effectively improves glycemic control. The modifications of lifestyle habits, such as regular physical activity and healthier dietary habits prove to be beneficial for patients. The aim of this study was to determine the factors affecting the level of physical activity in people with diabetes mellitus. Methods: Research material consisted of the data gathered from a diagnostic survey, which was conducted in a form of a questionnaire. The study included 60 people with type 1 or type 2 diabetes. Results: Unfortunately, the results show that not all of them were active enough, which is so crucial for stabilizing the disease. Conclusions: The diagnosis of diabetes in the respondents resulted in more time being spent by them on physical activity, which resulted in the improvement of diabetes control and the normalization of body weight according to BMI, thus increasing the effectiveness of diabetes treatment and reducing complications. The frequency of the physical activity undertaken by the respondents prior to the disease was not related to gender, however, after the diagnosis, it was dependent on gender

Ekspresja wybranych antygenów aktywacji na limfocytach T u chorych z rakiem krtani a cechy kliniczno-morfologiczne guza

76%

Starska K., Głowacka E., Łukomski M., Lewy-Trenda I., Józefowicz-Korczyńska M., Durko M., Lewkowicz P.

Polish Journal of Otolaryngology

2008

vol. 62

issue 6

674-679

Introduction. Results of studies analyzing the role of immunocompetent cells in tumor environment and whole peripheral blood indicate their responsibility for aggressiveness of neoplasm, prognosis and therapeutic effect. Atcivation of lymhocytes T is connected with expression the markers (antigens) on their surface. The aim of this study was the analysis of activation antigens expression on lymphocytes T in patients with laryngeal carcinoma and the connection with clinicomorphological features. Material and methods. Analysis of activation antigens expression CD69, CD71 and CD25, CD26, HLA/DR on lymphocytes T CD4+ i CD8+ in 33 patients with squamous cell carcinoma of the larynx was performed. Flow cytometry-based analysis of activation antigens in T cell cultures with and without PHA stimulation was used. The connection of these molecules and clinicomorphological features was examined (pT, pN, G, Anneroth, Batsakis and Lunas’ classifi cation). Results. The significant correlation between chosen markers of activation and tumor features were noted: pT with HLA/DR/CD4, CD69CD8, CD71CD8, pN with CD26CD8, G with CD25CD8, CD71CD8, ABL score with CD25CD4. Conclusion. Our data indicated the connection of immunocompetent cell activity and spread of neoplasm in patients with laryngeal carcinoma.

Ostre uszkodzenie nerek po środkach kontrastowych u dzieci z wadami układu krążenia – wyniki badania pilotażowego

64%

Tomczyk D., Jander A., Chrul S., Moszura T., Dryżek P., Krajewski W., Głowacka E., Tkaczyk M.

Pediatria i Medycyna Rodzinna

2016

vol. 12

issue 4

436-444

Introduction: Contrast-induced nephropathy – acute kidney injury is an acquired kidney injury that is an important factor in short- and long-term cardiovascular complications. Contrast-induced nephropathy – acute kidney injury continues to be diagnosed based on serum creatinine level. Serum creatinine, however, is a delayed indicator of contrast-induced nephropathy, as its levels typically peak between 1 and 3 days following contrast exposure. Currently, more sensitive biomarkers of kidney injury are sought, with human neutrophil lipocalin (also known as neutrophil gelatinase-associated lipocalin) highlighted in literature as a troponin-like biomarker of early nephropathy. Aim of the study: Changes in serum and urine neutrophil gelatinase-associated lipocalin levels were assessed in children with congenital heart diseases, following a scheduled cardiac catheterization procedure. Material and methods: The group studied comprised 16 patients. The neutrophil gelatinaseassociated lipocalin and creatinine levels, along with urine and serum neutrophil gelatinase-associated lipocalin/creatinine ratio were evaluated five times at different time intervals from the procedure. The group did not vary in respect of kidney function, preprocedure management, and volume expansion (hydration therapy) prior to the procedure. Results: In the assessed material, median neutrophil gelatinase-associated lipocalin rose as early as 2 hours after exposure to contrast as compared with baseline [median = 28.2 ng/mL (Quartile 1 = 22.8 – Quartile 3 = 33.77) vs. median = 25.87 ng/mL (Quartile 1 = 19.4 – Quartile 3 = 29.6)]. Serum neutrophil gelatinase-associated lipocalin level peaked in hour 6 of our study: median – 30.6 ng/mL (Quartile 1 = 22.32 – Quartile 3 = 42.17), then reverting to normal. Urine neutrophil gelatinaseassociated lipocalin peaked in hour 24 of the study, subsequently dropping below baseline in hour 48. Glomerular filtration was slightly impaired between hour 2 and 6, and later improvement of estimated glomerular filtration rate was noted. Conclusions: The analysis of the obtained results indicates the usefulness of measuring neutrophil gelatinase-associated lipocalin level for the diagnosis of early contrast-induced nephropathy – acute kidney injury in paediatric patients. Contrastinduced nephropathy – acute kidney injury biomarkers in such clinical circumstances elevate as early as 2 hours after intravenous administration of contrast agents.

Wprowadzenie: Ostre pokontrastowe uszkodzenie nerek jest nabytym uszkodzeniem nerek oraz istotnym czynnikiem krótko- i długoterminowych powikłań sercowo-naczyniowych. Ostre uszkodzenie nerek nadal rozpoznaje się na podstawie oznaczenia stężenia kreatyniny w surowicy. Stężenie kreatyniny wydaje się zbyt późnym markerem ostrego pokontrastowego uszkodzenia nerek, gdyż wzrasta z reguły w 1.–3. dobie po dożylnym podaniu środków kontrastowych. Obecnie poszukuje się czulszych biomarkerów uszkodzenia nerek. W piśmiennictwie wyróżnia się ludzką lipokalinę neutrofilową jako troponinopodobny marker wczesnego uszkodzenia nerek. Cel badania: Ocenie poddano zmiany stężenia ludzkiej lipokaliny neutrofilowej w moczu i surowicy u dzieci z wrodzonymi wadami serca po planowej procedurze cewnikowania serca. Materiał i metody: Grupa badana składała się z 16 pacjentów. Stężenie lipokaliny neutrofilowej i kreatyniny oraz wskaźnik lipokalina neutrofilowa/kreatynina w moczu i surowicy oceniono pięciokrotnie w różnych odstępach czasu. Grupa badana nie różniła się pod względem czynności nerek, procedury przygotowawczej i nawodnienia do zabiegu. Wyniki: W ocenionym materiale stwierdzono wzrost mediany stężenia ludzkiej lipokaliny neutrofilowej już w 2. godzinie od podania kontrastu w stosunku do wartości wyjściowych [mediana = 28,2 ng/ml (kwartyl 1. = 22,8 – kwartyl 3. = 33,77) vs mediana = 25,87 ng/ml (kwartyl 1. = 19,4 – kwartyl 3. = 29,6)]. Najwyższe stężenie lipokaliny neutrofilowej w surowicy występowało w 6. godzinie badania: mediana = 30,6 ng/ml (kwartyl 1. = 22,32 – kwartyl 3. = 42,17), po czym obniżało się do wartości wyjściowych. Wydalanie lipokaliny neutrofilowej z moczem wzrosło w 24. godzinie badania, by zmniejszyć się poniżej wartości wyjściowych w 48. godzinie. Nieznaczne upośledzenie filtracji kłębuszkowej obserwowano od 2. do 6. godziny badania, później stwierdzono poprawę w zakresie szacunkowej filtracji kłębuszkowej. Wnioski: Analiza wyników wskazuje na przydatność oznaczania stężenia ludzkiej lipokaliny neutrofilowej w diagnostyce wczesnego pokontrastowego uszkodzenia nerek u dzieci. Wskaźniki uszkodzenia nerek w tej sytuacji klinicznej wzrastają już w 2. godzinie od dożylnego zastosowania środków kontrastowych.

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1 Central European Journal of Sport Sciences and Medicine

1 Pediatria i Medycyna Rodzinna

1 Polish Journal of Otolaryngology

1 2016

1 2015

1 2008

3 Głowacka E.

1 Chrul S.

1 Dryżek P.

1 Durko M.

1 Jander A.

1 Józefowicz-Korczyńska M.

1 Krajewski W.

1 Latkowska A.

1 Lewkowicz P.

1 Lewy-Trenda I.

1 Moszura T.

1 Sieńko-Awieraniów E.

1 Starska K.

1 Stępień-Słodkowska M.

1 Tkaczyk M.

1 Tomczyk D.

1 Łukomski M.

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Factors Associated with Physical Activity in People with Diabetes

Ekspresja wybranych antygenów aktywacji na limfocytach T u chorych z rakiem krtani a cechy kliniczno-morfologiczne guza

Ostre uszkodzenie nerek po środkach kontrastowych u dzieci z wadami układu krążenia – wyniki badania pilotażowego