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Biotechnologia a bioterroryzm - jak nie zepsuć dobroczynnych owoców badań nad organizmami zmodyfikowanymi

100%

Kocik J.

Kosmos

2007

vol. 56

issue 3-4

233-236

Recent years have witness massive growth of basic research and diffusion of modern biotechnology, much more efficient that traditional methods, in production of large quantities of high quality specific proteins. Given examples of new advanced molecular biology and genetical engineering show unprecedented opportunities in medicine and human health care. At the same time manipulation of pathogenic microorganisms may bring some potential risks posed by these living modified organisms. The benefits of the more precise methods are becoming clear, but the precautionary approach demands that uncertainties and conjectural risks be addressed by corresponding research and legislation. The existing regulations on biosafety in some European countries require strengthening of protocols setting out appropriate procedures, including in particular informed agreement, in the field of safe transfer, handling and use of living modified pathogenic organisms.

Antiviral activity of novel oseltamivir derivatives against some influenza virus strains

45%

Kocik J., Kołodziej M., Joniec J., Kwiatek M., Bartoszcze M.

Acta Biochimica Polonica

2014

vol. 61

issue 3

509-513

The aim of this study was to investigate the in vitro cytotoxicity of oseltamivir derivatives and determine their activity against A/H1N1/PR/8/34 and A/H3N2/HongKong/8/68 - strains of influenza virus. Antiviral activity of these compounds was determined by using two methods. MTT staining was used to assess the viability of MDCK cells infected with influenza viruses and treated with various concentrations of drugs. In parallel, the effect of drugs on viral replication was assessed using the hemagglutination test. The most toxic compounds were: OS-64, OS-35, OS-29, OS-27 and OS-25, whereas OS-11, OS-20 and OS-23 were the least toxic ones. Statistically significant antiviral effect at a higher virus dose was shown by compounds: OS-11, OS-20, OS-27, OS-35, and OS-64. H3N2 virus was sensitive to 10-times lower concentrations of OS-11 and OS-35 than H1N1. At a lower infection dose, the antiviral activity was observed for OS-11, OS 27, OS-35 and OS-20. OS-64 turned out to be effective only at a high concentration. OS-23 showed no antiviral effect.

Diversity of influenza-like illness etiology in Polish Armed Forces in influenza epidemic season

27%

Kocik J., Niemcewicz M., Winnicka I., Michalski A., Bielawska-Drózd A., Kołodziej M., Joniec J., Cieślik P., Graniak G., Mirski T., Gaweł J., Bielecka-Oder A., Kubiak L., Russell K.

Acta Biochimica Polonica

2014

vol. 61

issue 3

489-494

The aim of this study was to conduct an epidemiological and laboratory surveillance of Influenza-Like Illnesses (ILI) in Polish Armed Forces, civilian military personnel and their families in 2011/2012 epidemic season, under the United States Department of Defense-Global Emerging Infections Surveillance and Response System (DoD-GEIS). ILI incidence data were analyzed in relation to age, gender, patient category as well as pathogen patterns. Multiple viral, bacterial and viral-bacterial co-infections were identified. Nose and throat swabs of active duty soldiers in the homeland country and in the NATO peacekeeping forces KFOR (Kosovo Force), as well as members of their families were tested for the presence of viral and bacterial pathogens. From October 2011 to May 2012, 416 specimens from ILI symptoms patients were collected and analyzed for the presence of viral and bacterial pathogens. Among viruses, coronavirus was the most commonly detected. In the case of bacterial infections, the most common pathogen was Staphylococcus aureus.

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2 Acta Biochimica Polonica

1 Kosmos

2 2014

1 2007

3 Kocik J.

2 Joniec J.

2 Kołodziej M.

1 Bartoszcze M.

1 Bielawska-Drózd A.

1 Bielecka-Oder A.

1 Cieślik P.

1 Gaweł J.

1 Graniak G.

1 Kubiak L.

1 Kwiatek M.

1 Michalski A.

1 Mirski T.

1 Niemcewicz M.

1 Russell K.

1 Winnicka I.

Search results

Biotechnologia a bioterroryzm - jak nie zepsuć dobroczynnych owoców badań nad organizmami zmodyfikowanymi

Antiviral activity of novel oseltamivir derivatives against some influenza virus strains

Diversity of influenza-like illness etiology in Polish Armed Forces in influenza epidemic season