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Advances in hematology – research that revolutionized patient care

100%
Wach M., Podhorecka M., Cioch M., Hus I., Wąsik-Szczepanek E., Sokołowska B., Hus M.
Polish Journal of Public Health
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2015
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vol. 125
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issue 1
32-35
EN
In the last decades, substantial strides have been made in the diagnosis, treatment, and prevention of blood diseases. The new drugs to be used in combination with cytostatic therapy have been developed, based on increased understanding of the biology of neoplasia. The diagnosis of several diseases is based exclusively on cytogenetic and molecular analysis which has become a part of routine diagnostic management. Moreover, molecular definition has allowed the introduction of therapy targeted at molecular change characteristic for a given disease. The introduction of novel agents for the treatment of hematological disorders has resulted in a great improvement in response rate and median survival. The aim of this study is to show advances and possible future directions in the treatment of chosen hematological malignancies during the recent decades.
2
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The expression BIRC6 gene in patients with chronic lymphocytic leukemia – a preliminary study

68%
Chomik P., Gil-Kulik P., Filas M., Wojcieszek A., Wilinski M., Karwat J., Kotula L., Niedojadlo A., Czop M., Bogucka-Kocka A., Cioch M., Pluta R., Kocki J.
Current Issues in Pharmacy and Medical Sciences
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2014
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vol. 27
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issue 3
179-182
EN
The BIRC6 gene encodes the Bruce (Apollon) protein. This belongs to the III class of Inhibitors of the Apoptosis Protein (IAP) and demonstrates anti-apoptotic activity (binding, inhibiting and degrading the caspases). Moreover, the Bruce protein shows multilevel activities and additional functions. The Bruce protein is involved in the maintenance of cell viability, and it is also suggested that it plays an important role in cell proliferation and diversification. Many researchers have noticed elevated BIRC6 gene expression in cell lines of brain cancer and ovarian carcinoma, leukemia, breast cancer and even in colorectal cancer tissues. Resistance to chemotherapy-inducted apoptosis in cancers characterized by BIRC6 gene over-expression was also reported. The aim of the study was to assess the BIRC6 gene expression in peripheral blood lymphocytes of patients diagnosed with chronic lymphocytic leukemia.
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