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Interaction of fibrinogen with nanosilica

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Rugal A., Gun’ko V., Barvinchenko V., Turov V., Semeshkina T., Zarko V.

Open Chemistry

2007

vol. 5

issue 1

32-54

Interaction of human plasma fibrinogen (HPF) with fumed nanosilica A-300 in a phosphate buffer solution (PBS) was studied using 1H NMR spectroscopy with layer-by-layer freezing-out of bulk and interfacial water in the temperature range of 210–273 K, TSDC (90 T FTIR, and UV spectroscopy methods. An increase in concentration of HPF in the PBS leads to a decrease in amounts of structured water (frozen at T FTIR and UV spectra show that the HPF adsorption on silica leads to structural changes of the protein molecules. These changes and formation of hybrid HPF/A-300 aggregates can increase the rate of clotting that is of importance on nanosilica application as a component of tourniquet preparations. [...]

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1 Open Chemistry

1 2007

1 Barvinchenko V.

1 Gun’ko V.

1 Rugal A.

1 Semeshkina T.

1 Turov V.

1 Zarko V.

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Interaction of fibrinogen with nanosilica