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1

Allergic inflammation - the role of adhesion process

100%
Pawliczak R., Kowalski M. L.
Postępy Higieny i Medycyny Doświadczalnej
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1997
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vol. 51
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issue 1
39-54
EN
Adhesion molecules (AMs) are one of the main research areas in biology, cytology and medicine. During last years a great number of AMs was discovered and employed in several mechanisms, including inflammation. Bronchial asthma, allergic rhinitis and conjunctivitis are considered as inflammatory disorders. Based on both in vitro and in vivo studies several mechanisms of selective recruitment eosinophils and basophils through AMs have been developed. Moreover, cytocines, biological peptides and other mediators play role in expression and function of adhesion molecules. Although several aspects of these processes still remains unclear, in vivo data (from animal and human experiments) document the existing of some of these mechanisms. Additional studies, including the use of adhesion molecule antagonists, will clarify the importance of leukocyte adhesion in the pathophysiology of allergic diseases. This review article describes characteristics, properties, regulation of expression and the role of leukocyte- -endothelial adhesion molecules in pathogenesis of allergic diseases.
2

Genetic polymorphism of beta 2-adrenoceptor and its role in pathology

100%
Woszczek G., Kowalski M. L.
Postępy Higieny i Medycyny Doświadczalnej
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2001
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vol. 55
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issue 1
37-51
EN
A few polymorphic loci has recently been identified in the beta 2-adrenoceptor gene that significantly influence receptor expression and its functions. Gene structure, regulation of the receptor expression and functions in regards to genetic polymorphisms and pathology are described.
3

A genom ? wide range analysis of gene expression ? application in biological sciences and medicine

100%
Pawliczak R., Kowalski M. L.
Postępy Higieny i Medycyny Doświadczalnej
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2002
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vol. 56
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issue 4
537-553
EN
Microarrays are one of the latest breakthroughs in experimental molecular biology, which allow monitoring of gene expression for tens of thousands of genes in parallel and are already producing huge amounts of valuable data. Microarray RNA expression on a genome-wide range is now a proven technology, although the idea of analysis of expression many genes in one sample is not new. Since the development of clone printing technology and oligonucleotide synthesis allowed to produce high density microarray. In this publication we provide the information about the technology, available detection systems and data analysis software. Comprehensive review of current or fundamental papers using microarray technology application in immunology, rheumatoid arthritis, oncology, cystis fibrosis research, primary pulmonary hypertension, psychiatry, and allergic airways inflammation is also included.
4

Leukotrienes ? mediators of inflammation

81%
Woszczek G., Pawliczak R., Kowalski M. L.
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EN
Leukotrienes are biologically active metabolites derived from arachidonic acid playing an important role in inflammatory responses. There are two main groups of leukotrienes: dihydroxy-leukotrienes (LTB4) and cysteinyl-leukotrienes (LTC4, LTD4, LTE4). By activating specific G-protein coupled receptors, leukotrienes take part in immune responses, like activation and chemotaxis of leukocytes. Several studies have shown that leukotrienes may play a significant role in pathomechanisms of inflammatory diseases of human airways, skin, digestive tract and heart.
5

Serum TNF-alpha levels in the neoplasm of patients qualified for surgical treatment

71%
Gendek-Kubiak H., Grzegorczyk J., Gendek E. G., Kowalski M. L., Berner J.
Archivum Immunologiae et Therapiae Experimentalis
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2001
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vol. 49
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issue 2 suppl.
97-102
EN
The aim of the study was to analyze serum tumor necrosis factor alpha (TNF-) levels in different neoplasm types qualified for surgical treatment and to evaluate their possible correlations with circulating immune complexes (CIC), IgG, IgM, and thecomplement (C) compounds: C1 inhibitor (C1i), C3c and C4 levels. Studies were performed in sera from 30 neoplasm patients before surgical treatment and in 10 persons from a control group (CG) with no malignancy. Serum TNF- levels were measured with the Cytogen ELISA kit. Average TNF- levels measured in neoplastic patient groups qualified for surgical treatment were not significantly different from the average TNF- level in the CG group.
6

Pre-operative levels of serum immunoglobulins, circulating immune complexes and complement proteins in patients with different types of neoplasms

71%
Gendek-Kubiak H., Grzegorczyk J., Gendek E. G., Kowalski M. L., Berner J.
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EN
In the sera of 30 neoplasm patients without metastases, the average IgG level was higher than in the control group (CG) (18.16 + 5.10 versus 12.62 + 2.14 g/l or 12.22 + 2.14 after excluding an out-lier). Average concentrations of CIC, IgM, C1i, C3c and C4 did not statistically differ between the groups. Dividing the patients' group into breast or ovary cancer (BC), melanoma (M), digestive tract cancer (DT) and other neoplasms (ON) subgroups revealed that the IgG increase did not apply to the BC group. Relatively decreased CIC concentrations in the BC and DT group and an increased C1i in the DT group were found. Several diversities detected in the humoral immunity indices' distributions and correlations suggest activation of different mechanisms depending on the neoplasm types.
7

A protective role of HLA-DR locus in patients with various clinical types of alopecia areata

61%
Broniarczyk-Dyla G., Prusinska-Bratos M., Dubla-Berner M., Arkuszewska C., Borowiec M., Kowalski M. L., Woszczek G.
Archivum Immunologiae et Therapiae Experimentalis
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2002
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vol. 50
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issue 5
333-336
EN
One of genetic factors associated with the development of alopecia areata (AA) is HLA locus. The study comprised 52 patients with AA, aged 10 to 64 years. The frequences of HLA-DR B alleles in patients and controls were compared. The control group comprised 152 healthy persons. Familiar occurrence of alopecia areata was seen in 7 cases (13.5%). Significantly lower frequency of HLA-DRB1*03 was observed in patients with AA in comparison to control group. In all patients with AA alleles HLA-DRB1*15/*16 occurred more frequently than in control group, but it was not significant after correction. In the group of patients with more severe form of alopecia areata (AAT/U) there was no significant difference in HLA- DR alleles distribution
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