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  1. 1 Biotechnologia

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  1. 1 1995

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  1. 1 Schlichtholz B.

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p53 - tumor suppressor gene

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Schlichtholz B.
Biotechnologia
|
1995
|
issue 3
91-103
EN
The structure of p53 tumor suppressor gene and molecular mechanisms of p53 function are characterized.The effects of the p53 protein on gene transcription, control of the cell cycle, DNA repair and synthesis, cell differentiation, and progrsmmed cell death are discussed.Besides clinical implication of inactivation of the p53 gene in the pathogenesis, diagnosis, and therapy of human cancer are mentioned.
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