The paper presented two definition of biotechnology as well as achivements of new biotechnology.The status of Biotechnology in Poland and the most important topics in biotechnology research was described.
Stability of stereoregular oligonucleotides towards selected nucleases, as well as the thermal stability of duplexes formed with DNA and RNa were investigated.Other strategies leading to antisense oligonucleotides try to avoid P-chirality by replacement of phosphates with achiral phosphorodithioates or moities like formacetal, sulphones, dietylsiloxanes etc.
In this report we discuss the possibility of using antisense oligonucleotides specific to PAI-1 mRNA to reversibly decrease PAI-1 level in blood plasma and thus prolong a half-life time endogenous plasminogen activators in circulation.
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