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OK-432 treatment of pediatric patients with recurrent thyroglossal duct cyst after surgery

100%
Ohta N., Fukase S., Nakazumi M., Sato T., Suzuki T.
Polish Journal of Otolaryngology
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2021
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vol. 75
|
issue 6
28-32
EN
Introduction: Recurrent thyroglossal duct cyst after surgery is not a rare condition and first-line treatment has not been established yet. Aim: Evaluation of outcomes and complications of OK-432 treatment in patients with recurrent thyroglossal duct cyst after surgery. Material and methods: This study is designed as a case series with planned data collection at Tohoku Medical and Pharmaceutical University and Fukase Clinic. Five patients with recurrent thyroglossal duct cyst after surgery received this therapy between January 2014 and February 2020 on an outpatient basis, without hospitalization. OK-432 solution was injected into the lesion using an 18- or 27-gauge needle, depending on the location and size of the lesion, as well as on possible complications. Results: Lesions showed marked reduction or total shrinkage in all patients, with no local scarring or deformity at the injection site. Side effects manifested as local pain at the site of injection and fever (37.5–38.5°C) observed in three patients, but the symptoms resolved within a few days. Conclusions: Since OK-432 therapy is simple, easy, safe and effective, it can be used as an alternative to surgery in the treatment of recurrent thyroglossal duct cyst after surgery.
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Endoscopic surgical management of sinonasal inverted papilloma extending to frontal sinuses

59%
Takahashi Y., Shoji F., Katori Y., Hidaka H., Noguchi N., Abe Y., Kakuta R. K., Suzuki T., Suzuki Y., Ohta N., Kakehata S., Okamoto Y.
Polish Journal of Otolaryngology
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2016
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vol. 70
|
issue 6
26-32
EN
Objective: Sinonasal inverted papilloma has been traditionally managed with external surgical approaches. Advances in imaging guidance systems, surgical instrumentation, and intraoperative multi-visualization have led to a gradual shift from external approaches to endoscopic surgery. However, for anatomical and technical reasons, endoscopic surgery of sinonasal inverted papilloma extending to the frontal sinuses is still challenging. Here, we present our experience in endoscopic surgical management of sinonasal inverted papilloma extending to one or both frontal sinuses. Methods: We present 10 cases of sinonasal inverted papilloma extending to the frontal sinuses and successfully removed by endoscopic median drainage (Draf III procedure) under endoscopic guidance without any additional external approach. Results: The whole cavity of the frontal sinuses was easily inspected at the end of the surgical procedure. No early or late complications were observed. No recurrence was identified after an average follow-up period of 39.5 months. Conclusion: Use of an endoscopic median drainage approach to manage sinonasal inverted papilloma extending to one or both frontal sinuses is feasible and seems effective.
3
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Chirurgia endoskopowa w leczeniu brodawczaka odwróconego jam nosa i zatok przynosowych rozprzestrzeniającego się do zatok czołowych

59%
Takahashi Y., Shoji F., Katori Y., Hidaka H., Noguchi N., Abe Y., Kakuta R. K., Suzuki T., Suzuki Y., Ohta N., Kakehata S., Okamoto Y.
Polish Journal of Otolaryngology
|
2016
|
vol. 70
|
issue 6
26-32
PL
Cel: Klasyczne metody leczenia brodawczaka odwróconego jam nosa i  zatok przynosowych to zabiegi z  dostępu zewnątrznosowego. Postępy w technikach nawigowania obrazowaniem, rozwój narzędzi chirurgicznych oraz metod obrazowania śródoperacyjnego doprowadziły do stopniowego odejścia od dostępów zewnątrznosowych na rzecz chirurgii endoskopowej. Ze względów anatomicznych i technicznych, chirurgia endoskopowa w leczeniu brodawczaka odwróconego jam nosa i zatok przynosowych rozprzestrzeniającego się do zatok czołowych wciąż pozostaje wyzwaniem. Poniżej przedstawiono doświadczenia własne autorów dotyczące chirurgii endoskopowej w leczeniu brodawczaka odwróconego jam nosa i zatok przynosowych rozprzestrzeniającego się do jednej lub obu zatok czołowych. Metody: Zaprezentowano 10 przypadków brodawczaka odwróconego jam nosa i  zatok przynosowych rozprzestrzeniającego się do zatok czołowych, usuniętego skutecznie za pomocą wewnątrznosowego otwarcia obu zatok czołowych (Draf III) pod kontrolą endoskopu, bez dodatkowego dojścia zewnątrznosowego. Wyniki: Po zakończonym zabiegu chirurgicznym cała jama obu zatok czołowych mogła być w  łatwy sposób kontrolowana. Nie obserwowano ani wczesnych, ani późnych powikłań. Po średnim okresie obserwacji (39,5 miesiąca), nie odnotowano nawrotów. Wnioski: Zastosowanie dojścia endoskopowego z obustronnym otwarciem zatok czołowych w leczeniu brodawczaka odwróconego jam nosa i  zatok przynosowych rozprzestrzeniającego się do jednej lub obu zatok czołowych jest możliwe i wydaje się być skuteczne.
4
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A Facelift Procedure for Resection of Benign Parapharyngeal Tumors

52%
Ohta N., Matsuura K., Osafune H., Suzuki T., Noguchi N., Hirabayashi H., Kitaya S., Kusano Y., Saito Y., Kawata R., Ikeda R., Ishida Y., Shimada H., Murakami K., Murakami K., Nakamura Y., Wada K.
Polish Journal of Otolaryngology
|
2021
|
vol. 75
|
issue 3
28-32
EN
Objective: The feasibility, surgical outcomes and possible risks and complications encountered during a facelift procedure for patients with parapharyngeal space (PPS) tumor were analyzed. Method: This retrospective analysis examined 10 patients who underwent surgery for PPS tumor using a facelift incision at our institutes between April 2015 and August 2019. Results: This study included four retro-styloid (benign nerve sheath tumor) and six pre-styloid tumors (pleomorphic adenoma). Mean tumor dimensions were 4.1 x 4.2 x 3.8 cm respectively. None of the patients needed conversion to conventional open resection. Transient sensory changes in the auricle occurred in 30% of the patients; however, all recovered within four months. In all the patients, postoperative scars were fully concealed by the auricle and hair. No recurrences were detected during a mean follow-up period of 16.6 months. Conclusion: The facelift procedure provides adequate visualization, workspace and excellent cosmetic results in properly selected cases.
5
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Lifting twarzy w resekcji łagodnych nowotworów przestrzeni przygardłowej

52%
Ohta N., Matsuura K., Osafune H., Suzuki T., Noguchi N., Hirabayashi H., Kitaya S., Kusano Y., Saito Y., Kawata R., Ikeda R., Ishida Y., Shimada H., Murakami K., Murakami K., Nakamura Y., Wada K.
Polish Journal of Otolaryngology
|
2021
|
vol. 75
|
issue 3
28-32
PL
Cel: Przeanalizowano opcje terapeutyczne, wyniki leczenia, potencjalne ryzyko i powikłania w czasie zabiegu liftingu twarzy u pacjentów z guzami przestrzeni przygardłowej (PPG). Metody: W retrospektywnej analizie uwzględniono 10 pacjentów poddawanych leczeniu operacyjnemu w naszym ośrodku w okresie od kwietnia 2015 r. do sierpnia 2019 r. z powodu guza PPG z wykorzystaniem cięcia do liftingu. Wyniki: W badaniu uwzględniono cztery guzy zarylcowate (łagodne nowotwory z osłonek nerwów obwodowych) i sześć guzów przedrylcowatych (gruczolak wielopostaciowy). Średnie wymiary guza wynosiły 4,1 x 4,2 x 3,8 cm. U żadnego pacjenta nie zaistniała potrzeba konwersji do otwartej resekcji. Przejściowe zaburzenia czucia w obrębie płatka pojawiły się u 30% osób, przy czym u wszystkich zmiany wycofały się w ciągu czterech miesięcy. U pacjentów ranę pooperacyjną całkowicie zakrywała małżowina uszna i włosy. Nie obserwowano wznowy w okresie obserwacji przez średnio 16.6 miesięcy. Wnioski: Lifting twarzy zapewnia dobre uwidocznienie guza, właściwe pole operacyjne i doskonałe efekty kosmetyczne u wybranych chorych.
6
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The expression of 11 beta hydroxysteroid dehydrogenase in severe allergic rhinitis

45%
Ohta N., Noguchi N., Takahashi T., Suzuki T., Kakuta R., Suzuki Y., Awataguchi T., Suzuki T., Takahashi Y., Shoji F., Wada K., Kawano T., Ono I., Kusano Y., Miyasaka T., Osafune H., Matsutani S., Yaginuma Y., Ishida Y., Saito Y., Yamazaki M., Ikeda R.
Polish Journal of Otolaryngology
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2019
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vol. 73
|
issue 2
18-22
EN
Objective: To clarify the roles of 11 beta-HSD in resistance to glucocorticoid therapy for allergic rhinitis, a case series study was conducted. Methods: The patient group consisted of 20 subjects with allergic rhinitis, aged from 21 to 46 years (mean age 26.5), who showed persistent GC resistance necessitating surgical removal of the inferior turbinate after 6 months’ GC treatment. The patients with poor response to GC treatment for 6 months’ were defined as GC resistance. The control group consisted of 10 subjects aged from 16 to 39 years (mean age 24.5) who underwent maxillofacial surgery, from whom nasal tissues were taken and who did not receive GC treatment. Nasal mucosal tissues from patients and cntorol subjects were examined immunohistochemically. The sections were washed with 0.01 M phosphate-buffered saline (PBS; pH 7.2) containing 0.15 M NaCl and 0.01% Triton X-100, and incubated for 2 h with rabbit polyclonal anti-11 beta HSD1 and 11 beta-HSD2 antibody (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA), each diluted 1:200 in PBS containing 0.1% bovine serum albumin. Immunostained sections were assessed under an Olympus microscope with an eyepiece reticule at 200 X magnification. Cell counts are expressed as means per high-power field (0.202 mm2). Control group means (arithmetic mean ± SD) were compared with patient group means by Mann–Whitney U-test at P = 0.05. Results: Although 11 beta-HSD1 was expressed to a similar extent in patients and controls, 11 beta-HSD2 was expressed significantly more in patients with severe allergic rhinitis, resulting in a increased HSD-1/HSD-2 ratio. The significantly increased expression of 11 beta-HSD2 in the nasal epithelium and submucosal inflammatory cells of patients with severe nasal allergy were observed in the present study. Conclusion: Our findings suggest that 11 beta-HSD2 plays an important role in resistance to glucocorticoid therapy for allergic rhinitis, and its expression might be used as an additional parameter indicating steroid resistance in allergic rhinitis.
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