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1

Globalne ocieplenie – kilka niewygodnych prawd

100%
Małecki A.
Biuletyn Polskiego Stowarzyszenia Wodoru i Ogniw Paliwowych
|
2009
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issue 4
52-59
2
Content available remote

Fluorometric assay of oleate-activated phospholipase D isoenzyme in membranes of rat nervous tissue and human platelets

51%
Krzystanek M., Trzeciak H. I., Krzystanek E., Małecki A.
Acta Biochimica Polonica
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2010
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vol. 57
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issue 3
369-372
EN
Phospholipase D plays a key role in the biosynthesis of phosphatidic acid, a second messenger involved in essential cellular processes. Oleate-activated phospholipase D was the first mammalian phospholipase D isoform to be discovered but is the least known. The study was aimed to test a fluorometric method of assessment of oleate-activated phospholipase D activity in different biological materials. The brain cortex of male Wistar rats, cultured rat brain astrocytes, and human platelets were processed to yield plasmatic membranes for experiments. To assess phospholipase D activity the modified fluorometric method was used. Previously, the method was used only to determine H2O2. In this enzyme-coupled assay phospholipase D activity is monitored indirectly using 10-acetyl-3,7-dihydroxyphenoxazine. First, phospholipase D cleaves exogenous phosphatidylcholine to yield choline and phosphatidic acid. Second, choline is oxidized by choline oxidase to betaine and H2O2. Finally, in the presence of horseradish peroxidase, H2O2 reacts with 10-acetyl-3,7-dihydroxyphenoxazine to generate the highly fluorescent product, resorufin. The concentration of resorufin was measured using excitation and emission at 560 nm and 590 nm, respectively. The proposed optimal parameters of the tested assay are 25 µg of rat brain cortex protein, 50 µg of rat brain astrocyte protein, and 50 µg of human platelet protein in a reaction volume of 200 µL, and 2 min enzymatic reaction at 37°C. The fluorometric method may be applied to assay phospholipase D in different biological materials.
3
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Role of physical activity in preventing disability in Parkinson’s disease

51%
Opara J., Małecki A., Mehlich K., Szczygieł J.
Medical Rehabilitation
|
2013
|
vol. 17(2)
18-22
PL
Choroba Parkinsona, która dotyka około 2% ludności powyżej 65 lat i ponad 4% osób, które ukończyły 85 lat, jest jedną z najczęstszych przyczyn niepełnosprawności ruchowej wśród chorób układu nerwowego. Powszechnie wiadomo, że aktywność fizyczna chorych na chorobę Parkinsona jest mniejsza niż w populacji ogólnej. Nieliczne badania naukowe potwierdziły niską aktywność fizyczną osób z chorobą Parkinsona. Mimo wprowadzenia lewodopy, jako złotego standardu leczenia, nowych agonistów receptorów dopaminowych, a nawet leczenia neurochirurgicznego, nie udaje się kontrolować postępującej niepełnosprawności ruchowej. Aktywność fizyczna odgrywa istotną rolę w rozwoju choroby. Poprawa aktywności fizycznej opóźnia rozwój niepełnosprawności ruchowej chorych i skutkuje podwyższeniem ich jakości życia. W piśmiennictwie naukowym można znaleźć wiele badań, z których wynika, że ćwiczenia i aktywność fizyczna prowadzą do: zmniejszenia śmiertelności, poprawy siły, poczucia równowagi i postawy ciała, mobilności i samodzielności w wykonywaniu czynności życia codziennego u osób z chorobą Parkinsona. Ćwiczenia i aktywność fizyczna pełnią także ważną rolę w zapobieganiu upadkom, które mogą być u chorych brzemienne w skutkach. W artykule poglądowym przedstawiliśmy przegląd piśmiennictwa poświęconego znaczeniu aktywności fizycznej w prewencji pierwotnej i jej wpływowi na rozwój niepełnosprawności w chorobie Parkinsona. W prewencji pierwotnej aktywność fizyczna jest szczególnie ważna w odniesieniu do płci męskiej. Przedstawiono różne zalecenia dotyczące aktywności fizycznej i różne metody jej oceny.
EN
Parkinson`s disease, which affects about 2% of the population over 65 years and more than 4% of those over 85 years, is one of the most frequent causes of physical disability from among the diseases of the nervous system. It is well known that physical activity in patients with Parkinson’s disease is less than in the general population. Only a few scientific studies have confirmed the low physical activity of people with Parkinson`s disease. Despite the application of levodopa, which now seems to be the gold standard treatment, the new dopamine agonists, and even neurosurgical treatment, one is not able to control the development of physical disability within Parkinson`s disease. Physical activity plays an important role in the development of the disease. Improving the amount and type of physical activity delays the development of the physical disability in patients and has a positive effect on their quality of life. In the scientific literature, one can find a lot of research which shows that exercise and physical activity lead to a reduction in mortality, an improvement in strength, the sense of balance and posture, mobility and independence in performing Activities of Daily Living (ADL) amongst patients with Parkinson`s disease. Exercise and physical activity play an important role in the prevention of falls, which can be dangerous for patients. In this paper an descriptive review of the literature devoted to the importance of physical activity and its impact on disability progression in Parkinson's disease has been presented. Physical activity is particularly important in relation to men and disease prevention. The different recommendations for physical activity and different methods of assessment have been described.
4
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The Relationship between Children's Blood Lead Level and Postural Stability

51%
Pawlas K., Pawlas N., Kmiecik-Małecka E., Małecki A.
Journal of Human Kinetics
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2008
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vol. 20
71-80
EN
Children, especially younger, are recognized as very susceptible to environmental lead exposure. In order to assess the effect of lead on spontaneous postural sway, we studied 327 children 4-13 years old, living in 4 cities in Upper Silesia an industrial region of Poland. Lead concentration in blood was measured by absorption atomic spectrometry (AAS) and posturography was performed using CATSYS 2000 - SWAY 7.0 equipment. Children's postural sway characteristics decreased with age. Particular variables had higher values for boys than girls and were positively associated with blood lead levels. There was an association between postural sway characteristics and smoking habits of mother, usage of aminoglycosides and paracetamol. Posturography seems to be a useful tool for assessment of lead exposure effects on the nervous system at low blood lead levels.
5
Content available remote

Effects of Regular Recreational Exercise Training on Serum ANGPTL3-Like Protein and Lipid Profile in Young Healthy Adults

45%
Smol E., Kłapcińska B., Kempa K., Fredyk A., Małecki A.
Journal of Human Kinetics
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2015
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vol. 49
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issue 1
109-118
EN
Evidence of the role of ANGPTL3, a liver-secreted glycoprotein, in serum lipid turnover, led us to hypothesize that this protein may be involved in modification of the lipid profile induced by exercise-training. Given the lack of data regarding this issue, the main goal of the present study was to investigate the effects of regular participation in a recreational physical activity program on serum ANGPTL3 and selected lipid profile measures in young, apparently healthy female and male adults. We compared serum ANGPTL3, lipid profile measures, common lipid ratios, the Atherogenic Index of Plasma (AIP) and glucose in fasting blood samples derived from 22 active physical education students including active females (AF, N=6) and males (AM, N=16) with samples from 28 relatively sedentary agematched peers, including female (SF, N=9) and male (SM, N=19) individuals not involved in any regular physical conditioning program. Despite high inter-individual variability of serum ANGPTL3, there was a general tendency toward higher serum ANGPTL3 and HDL-C in women compared to men, but without significant differences related to their physical activity status. Based on both routine lipid profile measures and lipid ratios, all participants had normal lipid profiles, normal glycemia, as well as favorable anthropometric indices not suggesting increased cardiometabolic risk. However, lower levels of the TG/HDL-C ratio and AIP in physically active compared to relatively sedentary participants, reflecting the predominance of large, buoyant LDL particles, strongly support the view of beneficial healthpromoting effects of regular participation in recreational sport activities.
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