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The negative impact of local recurrence on overall survival in adult patients with extremity localized osteosarcoma

100%
Goryń T., Szostakowski B., Pieńkowski A., Rutkowski P.
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2022
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vol. 87
|
issue 1
8-12
PL
Kostniakomięsak jest najczęstszym pierwotnym nowotworem złośliwym kości u dorosłych i najczęściej lokalizuje się się w kościach długich. Standardowe leczenie obejmuje chemioterapię okołooperacyjną i radykalną resekcję chirurgiczną. W przypadku lokalizacji kończynowej złotym standardem jest operacja oszczędzająca kończynę z wykorzystaniem różnych technik rekonstrukcyjnych. W naszej pracy przeanalizowano 175 dorosłych pacjentów w stadium I-III wg MSTS leczonych w naszej placówce w latach 2000-2017 z powodu kostniakomięsaka w lokalizacji kończynowej. Mediana obserwacji wyniosła 41 miesięcy (3-225 miesięcy). 111 pacjentów poddano operacji oszczędzającej kończynę, 80 pacjentów poddano resekcji guza, a następnie rekonstrukcji z wykorzystaniem endoprotezoplastyki poresekcyjnej, 31 pacjentów poddano resekcji miejscowej bez rekonstrukcji, a 64 pacjentów poddano amputacji. Wskaźniki 5-letniego przeżycia całkowitego (OS) i przeżycia wolnego od choroby (DFS) w grupie badanej wynosiły odpowiednio 62% i 52%, a oczekiwana długość życia 136 miesięcy. Wznowa miejscowa wystąpiła u 34 (19%) pacjentów w całej grupie, w tym 16 (17%) po rekonstrukcji, 11 (35%) po resekcji miejscowej i 7 (10%) po amputacji. W grupie pacjentów z nawrotem miejscowym wskaźnik 5-letniego przeżycia całkowitego (OS) wyniósł 30%, i był istotnie statystycznie gorszy niż pacjentów bez wznowy (5-letnie OS 70%).
EN
Osteosarcoma is the most common primary malignant bone tumour in adults and is usually located in long bones. Standard treatment consists of perioperative chemo-therapy and radical surgical resection. In the case of the extremity location, the gold standard is limb-sparing surgery using various reconstructive techniques. Our study analyzed 175 adult patients in MSTS I-III stage treated for extremity os-teosarcoma at our institution between 2000 and 2017. The median observation was 41 months (3-225 months). 111 patients were treated with limb-sparing surgery, 80 patients had tumour resection followed by endoprosthetic reconstruction, 31 patients had local resection without reconstruction and 64 patients underwent amputation. 5-year OS (overall survival) and DFS (disease-free survival) rates in the study group were 62% and 52%, respectively, and life expectancy was 136 months. Local recurrence occurred in 34 (19%) patients in the whole group, including 16 (17%) patients after reconstruction, 11 (35%) patients after local resection and 7 (10%) patients who had an amputation. In the group of patients with local recurrence, 5-year OS rate was 30%, statistically significantly worse than patients without recurrence (5-year OS 70%).
2
Content available remote

Synchronous Occurrence of Colon and Appendiceal Adenocarcinoma

100%
Goryń T., Meszka M., Pawlak J.
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vol. 86
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issue 3
147-150
EN
The study presented two cases of synchronous occurrence of colon and appendiceal adenocarcinoma. Both patients required surgical intervention, due to acute peritonitis during the course of acute appendicitis. In case of one patient we performed abdominal CT confirming the presence of sigmoid cancer. The patient was subjected to appendectomy and Hartmann’s operation. The second patient underwent an appendectomy, and colonoscopy performed two months later revealed the presence of rectal adenocarcinoma. The patient was subjected to low anterior rectal resection. The histopathological results considering both patients revealed the presence of synchronous colon and appendiceal adenocarcinoma.
3
Content available remote

Colon Lymphomas – Rare Case of Intestinal Resection

100%
Goryń T., Rykała C., Pawlak J.
Polish Journal of Surgery
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2015
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vol. 87
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issue 3
148-152
4
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Treatment of Vascular Complications After Kidney Transplantation

88%
Wiśniewska-Goryń J., Gorczyca-Wiśniewska E., Goryń T., Andziak P., Durlik M.
Polish Journal of Surgery
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2008
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vol. 80
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issue 3
132-138
EN
The aim of the study was to determine the frequency of occurrence and treatment methods of early vascular complications after kidney transplantation.Material and methods. A retrospective analysis comprised of 245 patients subjected to kidney transplantation during the period between 1998 and 2006 in our department. Of these, 236 patients received organs from deceased donors, while nine patients received organs from living donors. The occurrence of vascular complications and the diagnostic and treatment methods used were determined for each patient. Patients operated on during the period between 1998 and 2001 were compared to those operated on between 2002 and 2006.Results. Twenty-two patients presented with vascular complications after kidney transplantation. The following were observed: bleeding (6.1%), anastomotic stenosis (1.2%), renal vein thrombosis (0.81%), renal artery thrombosis (0.4%), and false aneurysm of the renal artery (0.4%). Nineteen patients underwent surgery, and two required intravascular procedures while one was subjected to conservative treatment. Good treatment results were obtained in 17 patients, while five patients had the transplanted kidney removed.Seventy-eight transplantations were performed in the first four years (1998-2001). In that period, vascular complications occurred in 13 patients (17%). During the following four years (2002-2006) we transplanted 167 patients, and vascular complications were observed in nine patients (5%). Statistical analysis showed a significant reduction (p=0.004-test chi2) in the number of vascular complications during the latter period.Conclusions. As surgeons gain experience treating transplant recipients, the number of vascular complications decreases. Diagnostics and treatment depends on the early visualization of complications by means of Doppler ultrasound and angio-MRI examinations. The use of intravascular techniques could be an effective and safe therapeutic method in the case of vascular complications.
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