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1

IMPACT OF EXCIPIENTS ON PHARMACEUTICAL AVAILABILITY OF FOLIC ACID FROM TABLETS

100%

Ostróżka-Cieślik A., Dolińska B., Ryszka F.

Acta Poloniae Pharmaceutica - Drug Research

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2018

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vol. 75

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issue 4

959-963

EN

The impact of excipients contained in individual formulations on the pharmaceutical availability of folic acid was investigated. The release rate of the active substance and the disintegration time of the tablets were analysed. It has been found that in the presence of sorbitol, glucose and starch, 100% of folic acid is released within 60 minutes, and in the presence of lactose and starch - 95%, and the release rates for them are 0.0717 min-1 and 0.0555 min-1 respectively.

2

PHYSICOCHEMICAL CHARACTERISTICS OF FUROSEMIDE INCORPORATED EUDRAGIT MICROSPHERES FORMULATED BY SPRAY-DRYING

100%

Ostróżka-Cieślik A., Sarecka-Hujar B., Jankowski A.

Acta Poloniae Pharmaceutica - Drug Research

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2018

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vol. 75

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issue 6

1369-1376

EN

Microspheres are one of the multicompartment drug delivery systems. The active substance is incorporated into a polymeric matrix. The aim of the study was to determine physicochemical properties of furosemide microspheres prepared with Eudragit L30 D-55 matrix and to analyse their stability and drug release. A test formulation at the drug-polymer ratio of 1:2 was used in the study. Furosemide was incorporated into the enteric matrix because it reduces gastric acid secretion and impairs gastric secretory functions. The optimum spray drying parameters were determined on the basis of preliminary tests: aspirator efficiency: 80%, Tin: 140°C, pump capacity: 10%. The designated Hausner ratio and Carr index indicate good flow properties of the obtained product. The stability tests show that the microspheres are physically stable under the applied storage conditions. Based on the analysis of furosemide release from microspheres, it has been found that it is a two-step process. In the first step, 28.68% of the active substance was released into a pH 1.2 buffer solution. In the second step, the remaining part of the active substance was released into a pH 6.8 buffer within 30 minutes.

3

Tips for optimizing organ preservation solutions

100%

Ostróżka-Cieślik A., Dolińska B., Ryszka F.

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2018

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vol. 65

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issue 1

9-15

EN

Organ injury during ischemia is one of the clinical problems of today's transplantation. It occurs during warm ischemia time (WIT) when the blood flow is cut off and during cold ischemia when a graft is chilled in situ until the circulation is restored to the recipient organism. Fast cooling of the organ slows down metabolism and activates intracellular enzymes, which minimizes the effects of warm ischemia. Unfortunately, hypothermia also results in inhibition of ATP synthesis, cell swelling and intracellular acidity. That is why research is continually being conducted to develop new fluids for rinsing and storing organs, as well as to optimize the composition of those that are already in use, which will allow for longer and more effective graft storage and restoration of their optimal functions after transplantation. This article provides current information on rinsing and storage fluids available on the global market. It also discusses tips for the fluid modifications with hormones and micronutrients.

4

Ocena dostępności farmaceutycznej magnezu z tabletek o niemodyfikowanej szybkości uwalniania

100%

Ostróżka-Cieślik A., Dolińska B., Ryszka F.

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vol. 69

166-171

EN

INTRODUCTION. Magnesium is one of the macroelements required to maintain normal body homeostasis. During studies, a positive effect in the prevention of cardiovascular disease, postmenopausal osteoporosis and diabetes was found. Unfortunately a deficiency of this element in the daily diet was observed, so supplementation is recommended. The aim of the study was to determine the influence of the kind of magnesium compound on the availability of Mg2+ with a tablet with an unmodified release rate. MATERIALS AND METHODS. The following preparations were used: Biomagnezja 150, Citromag B6 and Biomagnezja Plus (FZNP "Biochefa"). Examination of the release rate of the active substance was performed in a paddle apparatus at T = 37°C ± 0.5°C for 120 min., with a mixer at 50 revolutions/min. and using 0.1 mol/dm3 HCl (pH = 1.2). For analysis of the magnesium release, Statistica software with pharmaceutical extensions: Dissolution Profiles was used. RESULTS. Analysis of the tested products showed that the % of magnesium released increased in the following order: Biomagnezja Plus, Biomagnezja 150, Citromag B6 and was respectively 45%, 61% and 70 %. The release rate constant increased in the same order and it was respectively 0.0138 min-1, 0.0146 min-1, 0.018 min-1. CONCLUSIONS. The factors affecting the release of magnesium in vitro are the solubility of the compound, the presence of an inorganic anion or an organic ligand and the stability of the compound. A higher solubility makes a higher percentage of release. The presence of an organic ligand (hydrogen citrate) determines a greater percentage of the released dose in comparison with the magnesium oxide thereof.

PL

WSTĘP: Magnez jest jednym z makroelementów niezbędnych do zachowania prawidłowej homeostazy organizmu. Stwierdzono jego pozytywne działanie w profilaktyce chorób sercowo-naczyniowych, osteoporozy pomenopauzalnej i cukrzycy. Niestety, obserwuje się niedobory tego pierwiastka w codziennej diecie, dlatego wskazana jest jego suplementacja. Celem badań było określenie wpływu rodzaju związku magnezu na dostępność farmaceutyczną Mg2+ z tabletek o niemodyfikowanej szybkości uwalniania. MATERIAŁ I METODY: Do badań wykorzystano preparaty: Biomagnezja 150, Citromag B6 i Biomagnezja Plus (FZNP „Biochefa”). Badanie szybkości uwalniania substancji czynnej wykonano w aparacie łopatkowym w T = 37°C ± 0,5°C, w czasie 120 min, przy 50 obrotach mieszadła/min, stosując 0,1 mol/dm3 HCl (pH = 1,2). Do analizy przebiegu uwalniania zastosowano program Statistica Zestaw Farmaceutyczny: Profile Uwalniania. WYNIKI: Analiza badanych preparatów wykazała, że procent uwolnionego magnezu wzrastał w kolejności: Biomagnezja Plus, Biomagnezja 150, Citromag B6 i wynosił odpowiednio: 45%, 61% i 70%. W takiej samej kolejności rosły stałe szybkości uwalniania: 0,0138 min-1; 0,0146 min-1; 0,018 min-1. WNIOSKI: Czynnikami wpływającymi na uwalnianie magnezu w warunkach in vitro są rozpuszczalność związku, obecność nieorganicznego anionu lub organicznego liganda i trwałość związku. Im większa rozpuszczalność substancji, tym wyższy procent uwalniania. Obecność liganda organicznego (wodorocytrynianu) determinuje większy procent uwolnionej dawki magnezu w porównaniu z jego tlenkiem.

5

Determinants of telemedicine development in health care system

100%

Sarecka-Hujar B., Ostróżka-Cieślik A., Banyś A.

Annales Academiae Medicae Silesiensis

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2016

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vol. 70

214-219

EN

Nowadays, telemedicine is a rapidly developing field of medicine in Poland. The amended Act on the information system in health care, applicable from 2015, should facilitate access to e-health services for patients. The aim of the present study was to review data on the role of ICT solutions in various fields of medicine. The present review of the literature was based on peer-reviewed journal databases (PubMed, Medline, Embase, Google Scholar) and Internet sources. Publications and Internet sources, included in the current review, were published from 2008 to 2016. The development of information technology has a significant impact on the progress of telemedicine. Many countries (including Poland) provide e-health services to its citizens. The results of the study indicate that medical consultation, diagnosis and telecare can be successfully carried out at a distance. The benefits of telemedicine are significant, both to patients, people related to health professionals as well as for the payer.

PL

Telemedycyna jest formą świadczenia usług medycznych z wykorzystaniem narzędzi telekomunikacyjnych i technologii teleinformatycznych. Obowiązująca od 2015 roku nowelizacja ustawy o systemie informacji w ochronie zdrowia powinna ułatwić pacjentom dostęp do e-usług medycznych. Celem pracy było omówienie roli rozwiązań teleinformatycznych w różnych dziedzinach medycyny. Dokonano przeglądu piśmiennictwa, opierając się na bazach czasopism recenzowanych (PubMed, Medline, Embase, Google Scholar) oraz źródłach internetowych. Dane literaturowe, które włączono do przeglądu, pochodzą z lat 2008–2016. Rozwój technologii informatycznych istotnie wpływa na dynamiczny postęp w zakresie telemedycyny. Coraz więcej państw (w tym Polska) świadczy e-usługi medyczne swoim obywatelom. Wyniki badań wskazują, że konsultacje lekarskie, diagnostyka i teleopieka mogą być z powodzeniem prowadzone na odległość. Korzyści wynikające ze stosowania telemedycyny są wymierne zarówno dla pacjentów, osób związanych zawodowo ze służbą zdrowia, jak i płatnika.

6

Application of selected diffractive and microscopic methods to evaluate the physical state of drug and morphology of microspheres obtained by spray drying of furosemide with Eudragit L30 D-55.

76%

Ostróżka-Cieślik A., Sarecka-Hujar B., Krzykawski T., Karcz J., Banyś A., Jankowski A.

Acta Poloniae Pharmaceutica - Drug Research

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2018

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vol. 75

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issue 3

EN

In pharmaceutical technology, the analysis of physicochemical properties of raw materials, intermediates and products is part of quality control testing at each stage of designing formulations and in the routine evaluation of the final product. The aim of the study was to analyse the physical state of drug and the morphology of microspheres obtained by spray drying, where furosemide was incorporated in the polymeric matrix of Eudragit L30 D-55. The following optimal parameters of the spray drying process were established: aspirator capacity of 80%, T.in: 140 ° C, pump capacity: 10%. The laser diffraction method was used to analyse the size distribution of microspheres in the following furosemide-Eudragit L30 D-55 systems: 1:1, 1:3, 1:5. X-ray powder diffraction was applied to compare the degrees of crystallinity of the final product and the starting material. Furosemide has crystal structure both before and after spray drying, it occurs in the polymorphic forms (form I crystals). No reflection from the crystalline phase has been found on the diffraction pattern of Eudragit. This is an amorphous substance.

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IMPACT OF EXCIPIENTS ON PHARMACEUTICAL AVAILABILITY OF FOLIC ACID FROM TABLETS

PHYSICOCHEMICAL CHARACTERISTICS OF FUROSEMIDE INCORPORATED EUDRAGIT MICROSPHERES FORMULATED BY SPRAY-DRYING

Tips for optimizing organ preservation solutions

Ocena dostępności farmaceutycznej magnezu z tabletek o niemodyfikowanej szybkości uwalniania

Determinants of telemedicine development in health care system

Application of selected diffractive and microscopic methods to evaluate the physical state of drug and morphology of microspheres obtained by spray drying of furosemide with Eudragit L30 D-55.