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Prokaryotic toxin-antitoxin systems - the role in bacterial physiology and application in molecular biology

100%

Bukowski M., Rojowska A., Wladyka B.

2011

vol. 58

issue 1

1-9

Bacteria have developed multiple complex mechanisms ensuring an adequate response to environmental changes. In this context, bacterial cell division and growth are subject to strict control to ensure metabolic balance and cell survival. A plethora of studies cast light on toxin-antitoxin (TA) systems as metabolism regulators acting in response to environmental stress conditions. Many of those studies suggest direct relations between the TA systems and the pathogenic potential or antibiotic resistance of relevant bacteria. Other studies point out that TA systems play a significant role in ensuring stability of mobile genetic material. The evolutionary origin and relations between various TA systems are still a subject of a debate. The impact of toxin-antitoxin systems on bacteria physiology prompted their application in molecular biology as tools allowing cloning of some hard-to-maintain genes, plasmid maintenance and production of recombinant proteins.

Daptomycin-resistant Staphylococcus pettenkoferi of human origin

64%

Savini V., Kosecka M., Siegwart E., Marrollo R., Polilli E., Palmieri D., Fazii P., Carretto E., Międzobrodzki J., Bukowski M.

2016

vol. 63

issue 2

297-301

The importance of nosocomial infections caused by coagulase-negative staphylococci is constantly growing. The threat primarily affects immunocompromised patients, the elderly and neonates, particularly after invasive surgery. The problem is fundamentally exacerbated by expanding antibacterial drug resistance. A case report is presented of an 86-year-old patient who underwent a ruptured abdominal aortic aneurysm surgery and developed septicaemia upon surgical wound infection. The causal agent was likely a carbapenem-resistant Klebsiella pneumoniae, however, daptomycin-resistant Staphylococcus pettenkoferi was identified in blood cultures in the absence of daptomycin treatment. To the authors' knowledge, the case study presented is the first published episode of daptomycin-resistant S. pettenkoferi strain.

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2 Acta Biochimica Polonica

1 2016

1 2011

2 Bukowski M.

1 Carretto E.

1 Fazii P.

1 Kosecka M.

1 Marrollo R.

1 Międzobrodzki J.

1 Palmieri D.

1 Polilli E.

1 Rojowska A.

1 Savini V.

1 Siegwart E.

1 Wladyka B.

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Prokaryotic toxin-antitoxin systems - the role in bacterial physiology and application in molecular biology

Daptomycin-resistant Staphylococcus pettenkoferi of human origin